CY1112340T1 - PATIENTS FOR CANCER THERAPEUTIC TREATMENT CONNECTED WITH HUMAN PATIENCE VIRUS (HPV) AND OTHER PATIENTS - Google Patents
PATIENTS FOR CANCER THERAPEUTIC TREATMENT CONNECTED WITH HUMAN PATIENCE VIRUS (HPV) AND OTHER PATIENTSInfo
- Publication number
- CY1112340T1 CY1112340T1 CY20111101107T CY111101107T CY1112340T1 CY 1112340 T1 CY1112340 T1 CY 1112340T1 CY 20111101107 T CY20111101107 T CY 20111101107T CY 111101107 T CY111101107 T CY 111101107T CY 1112340 T1 CY1112340 T1 CY 1112340T1
- Authority
- CY
- Cyprus
- Prior art keywords
- peptides
- patients
- hpv
- cells
- patience
- Prior art date
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Αυτή η εφεύρεση σχετίζεται με το πεδίο της Μοριακής Φαρμακολογίας και ειδικά με την ανάπτυξη πεπτιδίων χρήσιμων στην θεραπευτική αγωγή επιθηλιακών όγκων που συνδέονται με ογκογόνους τύπους των HPVs. Ο κύριος στόχος αυτής της εφεύρεσης είναι να ταυτοποιήσει πεπτίδια η δομή των οποίων επιτρέπει το μπλοκάρισμα της περιοχής φωσφορυλίωσης της Κινάσης ΙΙ της Καζεϊνης με άμεση αλληλεπίδραση με μία τέτοια θέση. Στην παρούσα εφεύρεση δείχνονται έντεκα κυκλικά πεπτίδια με διαφορετικές αμινοξικές αλληλουχίες τα οποία αναστέλλουν την CHII φωσφορυλίωση in vitro, δείχνουν κυτταροτοξικότητα στα HPV-μετασχηματισμένα κύτταρα (CaSki) και επίσης αυξάνουν την ευαισθησία αυτών των κυττάρων στην κυτταροστατική επίδραση της ιντερφερόνης (IFN). Ακόμη, η εφεύρεση σχετίζεται με την χρήση αυτών των πεπτιδίων συζευγμένων ή συντηγμένων με άλλα πεπτίδια και χημικές ενώσεις που διεισδύουν στα κύτταρα όπως επίσης και με την χρήση και του πεπτιδίου και των χημικών μιμητικών μορίων.This invention relates to the field of Molecular Pharmacology and in particular to the development of peptides useful in the treatment of epithelial tumors associated with oncogenic types of HPVs. The main object of this invention is to identify peptides whose structure permits blocking of the casein kinase II phosphorylation site by direct interaction with such a site. The present invention shows eleven cyclic peptides with different amino acid sequences which inhibit CHII phosphorylation in vitro, show cytotoxicity to HPV-transformed cells (CaSki) and also increase the sensitivity of these cells to cytostatic (cytosolic) IFN. Further, the invention relates to the use of these peptides conjugated or fused with other peptides and chemicals that penetrate the cells as well as the use of both the peptide and the chemical mimetics.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU30901 | 2001-12-20 | ||
| EP02796490A EP1491553B1 (en) | 2001-12-20 | 2002-12-04 | Peptides for the treatment of cancer associated with the human papilloma virus (hpv) and other epithelial tumours |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1112340T1 true CY1112340T1 (en) | 2015-12-09 |
Family
ID=54782987
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20111101107T CY1112340T1 (en) | 2001-12-20 | 2011-11-16 | PATIENTS FOR CANCER THERAPEUTIC TREATMENT CONNECTED WITH HUMAN PATIENCE VIRUS (HPV) AND OTHER PATIENTS |
Country Status (1)
| Country | Link |
|---|---|
| CY (1) | CY1112340T1 (en) |
-
2011
- 2011-11-16 CY CY20111101107T patent/CY1112340T1/en unknown
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