CY1110802T1 - Benzimidazole derivatives: preparation and pharmaceutical applications - Google Patents

Benzimidazole derivatives: preparation and pharmaceutical applications

Info

Publication number
CY1110802T1
CY1110802T1 CY20101100868T CY101100868T CY1110802T1 CY 1110802 T1 CY1110802 T1 CY 1110802T1 CY 20101100868 T CY20101100868 T CY 20101100868T CY 101100868 T CY101100868 T CY 101100868T CY 1110802 T1 CY1110802 T1 CY 1110802T1
Authority
CY
Cyprus
Prior art keywords
preparation
pharmaceutical applications
benzimidazole derivatives
compounds
relates
Prior art date
Application number
CY20101100868T
Other languages
Greek (el)
Inventor
Dizhong Chen
Hong Yan Song
Eric T Sun
Niefang Yu
Yong Zou
Original Assignee
S*Bio Pte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP04775628A external-priority patent/EP1673349B1/en
Application filed by S*Bio Pte Ltd filed Critical S*Bio Pte Ltd
Publication of CY1110802T1 publication Critical patent/CY1110802T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
    • C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
    • C04B35/632—Organic additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6875—Nucleoproteins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Ceramic Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Manufacturing & Machinery (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Materials Engineering (AREA)
  • Structural Engineering (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Η παρούσα εφεύρεση αναφέρεται σε υδροξαμικές ενώσεις οι οποίες είναι αναστολείς της από-ακετυλάσης ιστόνης. Ειδικότερα, η παρούσα εφεύρεση αναφέρεται σε ενώσεις που περιέχουν βενζιμιδαζόλη και σε μεθόδους για την παρασκευή τους. Αυτές οι ενώσεις ενδέχεται να είναι χρήσιμες ως φαρμακευτικές ουσίες για την αντιμετώπιση των πολλαπλασιαστικών διαταραχών καθώς επίσης και άλλων ασθενειών που εμπλέκουν, αναφέρονται ή συνδέονται με την κακή ρύθμιση της από-ακετυλάσης ιστόνης (HDAC).The present invention relates to hydroxamic compounds which are histone deacetylase inhibitors. In particular, the present invention relates to compounds containing benzimidazole and to methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, reporting or associated with poor histone deacetylase (HDAC) regulation.

CY20101100868T 2003-09-22 2010-09-27 Benzimidazole derivatives: preparation and pharmaceutical applications CY1110802T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50421403P 2003-09-22 2003-09-22
US53089003P 2003-12-22 2003-12-22
EP04775628A EP1673349B1 (en) 2003-09-22 2004-09-21 Benzimidazole derivatives: preparation and pharmaceutical applications

Publications (1)

Publication Number Publication Date
CY1110802T1 true CY1110802T1 (en) 2015-06-10

Family

ID=43034219

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20101100868T CY1110802T1 (en) 2003-09-22 2010-09-27 Benzimidazole derivatives: preparation and pharmaceutical applications

Country Status (1)

Country Link
CY (1) CY1110802T1 (en)

Similar Documents

Publication Publication Date Title
CY1111789T1 (en) Heterocyclic compounds
CY1120141T1 (en) BENZAMIDI PRODUCER AS A HYGIENE DISCONNECTOR SUSPENDER WITH POWERFUL DIFFERENTIAL AND ANTI-COLLAPABLE ACTIVITY
MY142589A (en) Benzimidazole derivatives : preparation and pharmaceutical applications
CY1117995T1 (en) SECONDARY PRODUCTS OF CATEGOLAMIN AND MEDICINES CONTAINING THE THESE COMPOUNDS
CY1122349T1 (en) 1-BENZYL-3-HYDROXYMETHYLINDAZOLE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF DISEASES BASED ON THE EXPRESSION OF MCP-1, CXCR1 AND P40
CY1118768T1 (en) HYDRO-CYCLE ATP CONNECTION TRANSFER REGULATORS
CY1116754T1 (en) NITROCATECHOL PRODUCTS AS COMT INHIBITORS
CY1117584T1 (en) 1-Benzyl-3-hydroxymethyldazole derivative and their use in the therapeutic treatment of MCP-1-expressing MC3-C3
CY1117681T1 (en) 2,3-INDOLOAMINE DIAGNOSIS REGULATORS AND METHODS OF USING THESE
CY1112297T1 (en) Heterocyclic Suspensions of MEK and Methods of Using These
ECSP099525A (en) MEK INHIBITORS
CY1113306T1 (en) PRODUCTS OF KINOLIN AND USE FOR 5-HT6 PROJECTS
CY1113560T1 (en) AZAndolia Useful as Suspensions of JAK and Other Protein Kinases
CY1105621T1 (en) NEW FLUOROGLYCOSITE HETEROCYCLIC DERIVATIVES, DRUGS CONTAINING THESE COMPOUNDS AND THEIR USE
CY1114616T1 (en) CYCLOEXANE SPIRACYCLICAL PRODUCTS
CY1110954T1 (en) Semi-solid mucosal adhesives PHARMACEUTICAL FORMS
CY1113533T1 (en) HEROYROYL-SUBSTITUTED CYCLOXYL-1,4-DIAMIN PRODUCERS
CY1115318T1 (en) ISKINOLINO ATP CONNECTION CARRYING REGULATORS
NO20051966L (en) New pyrimidinamide derivatives and their use
CY1112376T1 (en) 2,3,4,9-tetrahydro-1H-carvasol derivative as CRTH2 receptor antagonists
CY1109227T1 (en) Derivative of 5-phenyl-4-methyl-thiazol-2-yl-amine as Inhibitors of the Phosphatidylinositol 3 (P13) Thionyl Methyl Enzyme (P13) Thionyl
CY1113314T1 (en) (3-Aryl-piperazin-1-yl) derivatives of 6,7-dialkoxycinazoline, 6,7-dialkoxyphalazine and 6,7-dialkoxysuccinoline
NO20061253L (en) Acetylene derivatives as inhibitors of histone deacetylase
NO20044744L (en) Carbamic acid compounds comprising a piperazine link as HDASin inhibitors
CY1115082T1 (en) Substituted 1,3-bisphenylpropane derivatives, preparations and their uses