CY1108451T1 - TRIAZOLYLOTROPANI PRODUCTS AS REGULATORS CCR5 - Google Patents

TRIAZOLYLOTROPANI PRODUCTS AS REGULATORS CCR5

Info

Publication number
CY1108451T1
CY1108451T1 CY081101203T CY081101203T CY1108451T1 CY 1108451 T1 CY1108451 T1 CY 1108451T1 CY 081101203 T CY081101203 T CY 081101203T CY 081101203 T CY081101203 T CY 081101203T CY 1108451 T1 CY1108451 T1 CY 1108451T1
Authority
CY
Cyprus
Prior art keywords
triazolylotropani
ccr5
regulators
products
optionally substituted
Prior art date
Application number
CY081101203T
Other languages
Greek (el)
Inventor
Manoussos Perros
David Anthony Price
Blanda Luzia Christa Stammen
Anthony Wood
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0014046A external-priority patent/GB0014046D0/en
Priority claimed from GB0015835A external-priority patent/GB0015835D0/en
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of CY1108451T1 publication Critical patent/CY1108451T1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates

Abstract

Η παρούσα εφεύρεση παρέχει ενώσεις του τύπου: όπου R1 είναι C3-6 κυκλοαλκύλιο, κατά περίπτωση υποκατεστημένο με ένα ή περισσότερα άτομα φθορίου· και R2 είναι φαινύλιο, κατά περίπτωση υποκατεστημένο με ένα ή περισσότερα άτομα άνθρακα, και φαρμακευτικώς αποδεκτά άλατα και διαλύματα τους· σε συνδυασμό με έναν ή περισσότερους πρόσθετους θεραπευτικούς παράγοντες.The present invention provides compounds of the formula: wherein R1 is C3-6 cycloalkyl, optionally substituted with one or more fluorine atoms; and R2 is phenyl, optionally substituted with one or more carbon atoms, and their pharmaceutically acceptable salts and solutions; combination with one or more additional therapeutic agents.

CY081101203T 2000-05-26 2008-10-24 TRIAZOLYLOTROPANI PRODUCTS AS REGULATORS CCR5 CY1108451T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0014046A GB0014046D0 (en) 2000-05-26 2000-05-26 Compounds useful in therapy
GB0015835A GB0015835D0 (en) 2000-06-27 2000-06-27 Compounds useful in therapy
EP20040004193 EP1526134B1 (en) 2000-05-26 2001-05-09 Triazolyl tropane derivatives as ccr5 modulators

Publications (1)

Publication Number Publication Date
CY1108451T1 true CY1108451T1 (en) 2014-04-09

Family

ID=26244452

Family Applications (2)

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CY200800006C CY2008006I1 (en) 2000-05-26 2008-03-17 TROPANIC PRODUCTS USEFUL IN THEPAPETIKI
CY081101203T CY1108451T1 (en) 2000-05-26 2008-10-24 TRIAZOLYLOTROPANI PRODUCTS AS REGULATORS CCR5

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY200800006C CY2008006I1 (en) 2000-05-26 2008-03-17 TROPANIC PRODUCTS USEFUL IN THEPAPETIKI

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EP (3) EP1284974B1 (en)
JP (2) JP3693957B2 (en)
KR (2) KR100548854B1 (en)
CN (2) CN100355753C (en)
AP (1) AP1965A (en)
AR (2) AR028622A1 (en)
AT (2) ATE407134T1 (en)
AU (2) AU2001252482B2 (en)
BG (1) BG65966B1 (en)
BR (1) BRPI0110955B8 (en)
CA (1) CA2408909C (en)
CR (1) CR10145A (en)
CU (1) CU23288B7 (en)
CY (2) CY2008006I1 (en)
CZ (1) CZ299102B6 (en)
DE (3) DE60102233T2 (en)
DK (2) DK1284974T3 (en)
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EA (2) EA005382B1 (en)
EE (1) EE05110B1 (en)
EG (1) EG24137A (en)
ES (3) ES2401812T3 (en)
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GE (1) GEP20063799B (en)
HK (3) HK1054927A1 (en)
HR (1) HRP20020938B1 (en)
HU (1) HU225810B1 (en)
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