CU23718B7 - DERIVATIVES OF 5-PHENYL-PENTANOIC ACID AS INHIBITORS OF THE METALOPROTEINASE OF THE MATRIX. - Google Patents
DERIVATIVES OF 5-PHENYL-PENTANOIC ACID AS INHIBITORS OF THE METALOPROTEINASE OF THE MATRIX.Info
- Publication number
- CU23718B7 CU23718B7 CU20070198A CU20070198A CU23718B7 CU 23718 B7 CU23718 B7 CU 23718B7 CU 20070198 A CU20070198 A CU 20070198A CU 20070198 A CU20070198 A CU 20070198A CU 23718 B7 CU23718 B7 CU 23718B7
- Authority
- CU
- Cuba
- Prior art keywords
- matrix
- compounds
- metaloproteinase
- inhibitors
- phenyl
- Prior art date
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención se refiere a ciertos B-hidroxi-ácidos y a los procesos para la síntesis de los mismos. Esta invención también se refiere a composiciones farmacológicas que contienen los compuestos de la presente invención, y a métodos para el tratamiento del asma, artritis reumatoide, COPD, rinitis, osteoartritis psoriásica, psoriasis, fibrosis pulmunar, inflamación pulmunar, síndrome de diestres respiratorio agudo, periodontitis, esclerosis múltiple, gingivitis, ateroesclerosis, proliferación neo-intimal, los cuales conducen a restenosis y a falla isquémica del corazón, ataques, enfermedades renales, metástasis tumoral y otros desórdenes inflamatorios caracterizados por la sobre-expresión y la sobre-activación de una metaloproteinasa de la matriz, utilizando los compuestos.The present invention relates to certain B-hydroxy acids and the processes for their synthesis. This invention also relates to pharmacological compositions containing the compounds of the present invention, and to methods for the treatment of asthma, rheumatoid arthritis, COPD, rhinitis, psoriatic osteoarthritis, psoriasis, pulmonary fibrosis, lung inflammation, acute respiratory dieteres syndrome, periodontitis , multiple sclerosis, gingivitis, atherosclerosis, neo-intimal proliferation, which lead to restenosis and ischemic heart failure, seizures, kidney diseases, tumor metastases and other inflammatory disorders characterized by over-expression and over-activation of a metalloproteinase of the matrix, using the compounds.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20070198A CU23718B7 (en) | 2007-08-21 | 2007-08-21 | DERIVATIVES OF 5-PHENYL-PENTANOIC ACID AS INHIBITORS OF THE METALOPROTEINASE OF THE MATRIX. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20070198A CU23718B7 (en) | 2007-08-21 | 2007-08-21 | DERIVATIVES OF 5-PHENYL-PENTANOIC ACID AS INHIBITORS OF THE METALOPROTEINASE OF THE MATRIX. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CU23718B7 true CU23718B7 (en) | 2011-10-14 |
Family
ID=45000137
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CU20070198A CU23718B7 (en) | 2007-08-21 | 2007-08-21 | DERIVATIVES OF 5-PHENYL-PENTANOIC ACID AS INHIBITORS OF THE METALOPROTEINASE OF THE MATRIX. |
Country Status (1)
| Country | Link |
|---|---|
| CU (1) | CU23718B7 (en) |
-
2007
- 2007-08-21 CU CU20070198A patent/CU23718B7/en not_active IP Right Cessation
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CO6680674A2 (en) | Matrix metalproteinase inhibitors | |
| EA201390404A1 (en) | INHIBITORS OF MATRIC METAL PROTEINASE | |
| BR112013006929A2 (en) | compound of formula I, pharmaceutical composition, process for preparing compounds of formula 9, 16, 20, 27 and 30 | |
| CU20110134A7 (en) | INHIBITORS OF THE METALOPROTEINASE MATRIX | |
| BRPI0915692B8 (en) | compounds derived from 1,2,5-oxadiazoles, their solid form, their composition, as well as their uses | |
| CL2016002888A1 (en) | Compounds derived from pyrazolopyridines and pyrazolopyrimidines; pharmaceutical composition and its use as selective inhibitors of janus kinases (jak) in the treatment of diseases such as nasal congestion, asthma, epoc, allergic rhinitis, diabetes among others. | |
| UY29839A1 (en) | PHENOXYACETIC ACIDS REPLACED, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, PROCESSES FOR THEIR PREPARATION AND APPLICATIONS. | |
| BR112014014809A2 (en) | pharmaceutical compositions comprising glitazones and nrf2 activators | |
| BR112012019367A2 (en) | heat integration process for ethanol production and purification process. | |
| ECSP088335A (en) | AMIDA PYRIMIDINE COMPOUNDS AS PGDS INHIBITORS | |
| BRPI0911105A2 (en) | compounds containing an anti-inflammatory pharmacophorus, pharmaceutical composition, as well as their use | |
| PE20091419A1 (en) | ACID DERIVATIVES OF CARBOXYCLOALKYLAMINE AS MODULATORS OF SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTORS | |
| PA8642801A1 (en) | SUBSTITUTED AMIDAS OF TIENOPIRROLCARBOXILICO ACID, AMIDAS OF THE PIRROLOTIAZOLCARBOXILICO ACID AND RELATED ANALOGS AS INHIBITORS OF CASEINA CINASA I | |
| CU24103B1 (en) | SPIRITS DERIVED AMIDO SPIROCYCLES AND SALTS PHARMACEUTICALLY ACCEPTABLE OF THE SAME | |
| CU23757B7 (en) | BENCILAMINS, A PROCESS FOR ITS PRODUCTION AND ITS USE AS ANTI-INFLAMMATORY AGENTS | |
| GEP20094786B (en) | 5-phenyl-pentanoic acid derivatives as matrix metalloproteinase inhibitors for the treatment of asthma and other diseases | |
| CL2011000296A1 (en) | Process for preparing 4-oxo-octahydro-indole-1-carboxylic acid methyl ester and intermediate compounds used. | |
| CL2011000093A1 (en) | Compounds derived from a piperidinyl ester of biphenyl-2-ylcarbamic acid; pharmaceutical composition; pharmaceutical combination; and its use for bronchoconstriction, obstructive or inflammatory diseases of the respiratory tract. | |
| PH12017500383A1 (en) | Pyrazolothiazole compound and medicine comprising same | |
| ES2529865B8 (en) | USE OF COMPOUNDS DERIVED FROM SIRES OF PIRIDAZINO [1 ', 6': 1,2] PIRIDO [3,4-b] INDOLINIO AS ANTI-INFLAMMATORY AGENTS | |
| CU23718B7 (en) | DERIVATIVES OF 5-PHENYL-PENTANOIC ACID AS INHIBITORS OF THE METALOPROTEINASE OF THE MATRIX. | |
| EA201291235A1 (en) | NEW WAYS | |
| AR086220A1 (en) | PROCESS FOR THE PRODUCTION OF 4-CHLOROACETOACETILO CHLORIDE, AND ESTERES, AMIDAS AND IMIDAS OF THE 4-CHLOROACETOACETIC ACID | |
| BR112012007755A2 (en) | piperidinyl derivative drugs as modulators of chemokine receptor activity | |
| MX2018010334A (en) | Crystal of compound having jak-inhibiting activity. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Lapse (for not paying fees) |