CU23680B7 - SUBSTITUTED OXAZOL DERIVATIVES AND THEIR USE AS INHIBITORS OF THYROSINE KINASE - Google Patents

SUBSTITUTED OXAZOL DERIVATIVES AND THEIR USE AS INHIBITORS OF THYROSINE KINASE

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Publication number
CU23680B7
CU23680B7 CU20070222A CU20070222A CU23680B7 CU 23680 B7 CU23680 B7 CU 23680B7 CU 20070222 A CU20070222 A CU 20070222A CU 20070222 A CU20070222 A CU 20070222A CU 23680 B7 CU23680 B7 CU 23680B7
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CU
Cuba
Prior art keywords
inhibitors
substituted oxazol
thyrosine kinase
derivatives
oxazol derivatives
Prior art date
Application number
CU20070222A
Other languages
Spanish (es)
Other versions
CU20070222A7 (en
Inventor
Martine Croisy
Alain Moussy
David Grierson
Abdellah Benjahad
Original Assignee
Inst Curie
Centre Nat Rech Scient
Ab Science
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Curie, Centre Nat Rech Scient, Ab Science filed Critical Inst Curie
Priority to CU20070222A priority Critical patent/CU23680B7/en
Publication of CU20070222A7 publication Critical patent/CU20070222A7/en
Publication of CU23680B7 publication Critical patent/CU23680B7/en

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Abstract

La presente invención concierne a nuevos compuestos seleccionados entre derivados de oxazol sustituidos de fórmula (I) que, de manera selectiva, modulan, regulan, y/o inhiben la transducción de senales mediada por ciertas tirosina quinasas nativas y/o mutantes implicadas en una variedad de enfermedades humanas y animales como los trastornos celulares poliferativos, metabólicos, alérgicos y degenerativos. Más específicamente, estos compuestos son inhibidores potentes y selectivos de c-kit, bcr-abl y Flt-3.The present invention concerns new compounds selected from substituted oxazole derivatives of formula (I) that, selectively, modulate, regulate, and / or inhibit signal transduction mediated by certain native tyrosine kinases and / or mutants involved in a variety of human and animal diseases such as poliferative, metabolic, allergic and degenerative cell disorders. More specifically, these compounds are potent and selective inhibitors of c-kit, bcr-abl and Flt-3.

CU20070222A 2007-10-02 2007-10-02 SUBSTITUTED OXAZOL DERIVATIVES AND THEIR USE AS INHIBITORS OF THYROSINE KINASE CU23680B7 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CU20070222A CU23680B7 (en) 2007-10-02 2007-10-02 SUBSTITUTED OXAZOL DERIVATIVES AND THEIR USE AS INHIBITORS OF THYROSINE KINASE

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU20070222A CU23680B7 (en) 2007-10-02 2007-10-02 SUBSTITUTED OXAZOL DERIVATIVES AND THEIR USE AS INHIBITORS OF THYROSINE KINASE

Publications (2)

Publication Number Publication Date
CU20070222A7 CU20070222A7 (en) 2010-12-08
CU23680B7 true CU23680B7 (en) 2011-07-11

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Family Applications (1)

Application Number Title Priority Date Filing Date
CU20070222A CU23680B7 (en) 2007-10-02 2007-10-02 SUBSTITUTED OXAZOL DERIVATIVES AND THEIR USE AS INHIBITORS OF THYROSINE KINASE

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CU (1) CU23680B7 (en)

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Publication number Publication date
CU20070222A7 (en) 2010-12-08

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