CU23680B7 - SUBSTITUTED OXAZOL DERIVATIVES AND THEIR USE AS INHIBITORS OF THYROSINE KINASE - Google Patents
SUBSTITUTED OXAZOL DERIVATIVES AND THEIR USE AS INHIBITORS OF THYROSINE KINASEInfo
- Publication number
- CU23680B7 CU23680B7 CU20070222A CU20070222A CU23680B7 CU 23680 B7 CU23680 B7 CU 23680B7 CU 20070222 A CU20070222 A CU 20070222A CU 20070222 A CU20070222 A CU 20070222A CU 23680 B7 CU23680 B7 CU 23680B7
- Authority
- CU
- Cuba
- Prior art keywords
- inhibitors
- substituted oxazol
- thyrosine kinase
- derivatives
- oxazol derivatives
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención concierne a nuevos compuestos seleccionados entre derivados de oxazol sustituidos de fórmula (I) que, de manera selectiva, modulan, regulan, y/o inhiben la transducción de senales mediada por ciertas tirosina quinasas nativas y/o mutantes implicadas en una variedad de enfermedades humanas y animales como los trastornos celulares poliferativos, metabólicos, alérgicos y degenerativos. Más específicamente, estos compuestos son inhibidores potentes y selectivos de c-kit, bcr-abl y Flt-3.The present invention concerns new compounds selected from substituted oxazole derivatives of formula (I) that, selectively, modulate, regulate, and / or inhibit signal transduction mediated by certain native tyrosine kinases and / or mutants involved in a variety of human and animal diseases such as poliferative, metabolic, allergic and degenerative cell disorders. More specifically, these compounds are potent and selective inhibitors of c-kit, bcr-abl and Flt-3.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CU20070222A CU23680B7 (en) | 2007-10-02 | 2007-10-02 | SUBSTITUTED OXAZOL DERIVATIVES AND THEIR USE AS INHIBITORS OF THYROSINE KINASE |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CU20070222A CU23680B7 (en) | 2007-10-02 | 2007-10-02 | SUBSTITUTED OXAZOL DERIVATIVES AND THEIR USE AS INHIBITORS OF THYROSINE KINASE |
Publications (2)
Publication Number | Publication Date |
---|---|
CU20070222A7 CU20070222A7 (en) | 2010-12-08 |
CU23680B7 true CU23680B7 (en) | 2011-07-11 |
Family
ID=43401419
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CU20070222A CU23680B7 (en) | 2007-10-02 | 2007-10-02 | SUBSTITUTED OXAZOL DERIVATIVES AND THEIR USE AS INHIBITORS OF THYROSINE KINASE |
Country Status (1)
Country | Link |
---|---|
CU (1) | CU23680B7 (en) |
-
2007
- 2007-10-02 CU CU20070222A patent/CU23680B7/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CU20070222A7 (en) | 2010-12-08 |
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Legal Events
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FG | Grant of patent | ||
FD | Lapse (for not paying fees) |