CU23404A1 - NEISSERIA MENINGITIDIS CAPSULAR POLYSACARIDS AS MUCOSOPT IMMUNOPOTENTIZERS AND RESULTING FORMULATIONS - Google Patents

NEISSERIA MENINGITIDIS CAPSULAR POLYSACARIDS AS MUCOSOPT IMMUNOPOTENTIZERS AND RESULTING FORMULATIONS

Info

Publication number
CU23404A1
CU23404A1 CU20030270A CU20030270A CU23404A1 CU 23404 A1 CU23404 A1 CU 23404A1 CU 20030270 A CU20030270 A CU 20030270A CU 20030270 A CU20030270 A CU 20030270A CU 23404 A1 CU23404 A1 CU 23404A1
Authority
CU
Cuba
Prior art keywords
polysaccharides
formulations
neisseria meningitidis
meningitidis
similar
Prior art date
Application number
CU20030270A
Other languages
Spanish (es)
Inventor
Blanco Sonia Gonzalez
Portilla Tania Carmenate
Espina Maite Delgado
Perez Olivia Niebla
Garcia Gretel Sardinas
Feyt Rolando Pajon
Rubido Julio Cesar Aguilar
Original Assignee
Ct Ingenieria Genetica Biotech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ct Ingenieria Genetica Biotech filed Critical Ct Ingenieria Genetica Biotech
Priority to CU20030270A priority Critical patent/CU23404A1/en
Priority to ARP040104182A priority patent/AR046840A1/en
Priority to PCT/CU2004/000014 priority patent/WO2005049076A1/en
Publication of CU23404A1 publication Critical patent/CU23404A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55583—Polysaccharides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

Uso de polisacáridos capsulares de distintos serogrupos de Neisseria meningitidis, como agentes inmunopotenciadores e inmunomodulares, útiles para el desarrollo de vacunas. En la presente invención se administran dichos polisacáridos para incrementar la respuesta inmune contra antígenos heterólogos que han sido coadministrados por la vía muscusal. Se obtienen formulaciones múltiples de los polisacáridos capsulares de N. Meningitidis y antígenos heterólogos que al ser administradas por vías mucosales, producen niveles de inmunogenicidad similares a los obtenidos después de la administración parenteral de combinaciones similares a los obtenidos después de la administración parenteral de combinaciones similares. El uso de dichos polisacáridos como inmunopotenciadores permite prescindir del empleo de otros adyuvantes mucosales. Este nuevo uso de los polisacáridos capsulares de N. meningitidis y las formulaciones antigénicas resultantes son aplicables en la industria farmacéutica como formulaciones vacúnales preventivas o terapéuticas.Use of capsular polysaccharides from different serogroups of Neisseria meningitidis, as immunopotentiating and immunomodular agents, useful for vaccine development. In the present invention, said polysaccharides are administered to increase the immune response against heterologous antigens that have been coadministered by the muscle route. Multiple formulations of the capsular polysaccharides of N. Meningitidis and heterologous antigens are obtained which, when administered by mucosal routes, produce immunogenicity levels similar to those obtained after parenteral administration of combinations similar to those obtained after parenteral administration of similar combinations. . The use of said polysaccharides as immunopotentiators makes it possible to dispense with the use of other mucosal adjuvants. This new use of N. meningitidis capsular polysaccharides and the resulting antigenic formulations are applicable in the pharmaceutical industry as preventive or therapeutic vaccine formulations.

CU20030270A 2003-11-19 2003-11-19 NEISSERIA MENINGITIDIS CAPSULAR POLYSACARIDS AS MUCOSOPT IMMUNOPOTENTIZERS AND RESULTING FORMULATIONS CU23404A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CU20030270A CU23404A1 (en) 2003-11-19 2003-11-19 NEISSERIA MENINGITIDIS CAPSULAR POLYSACARIDS AS MUCOSOPT IMMUNOPOTENTIZERS AND RESULTING FORMULATIONS
ARP040104182A AR046840A1 (en) 2003-11-19 2004-11-12 CAPSULAR POLISACARIDS OF NEISSERIA MENINGITIDIS AS MUCOSOPT IMMUNOPOTENCERS AND RESULTING FORMULATIONS
PCT/CU2004/000014 WO2005049076A1 (en) 2003-11-19 2004-11-18 Use of capsular neisseria meningitidis polysaccharides as mucosal immunopotentiators and resulting formulations

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU20030270A CU23404A1 (en) 2003-11-19 2003-11-19 NEISSERIA MENINGITIDIS CAPSULAR POLYSACARIDS AS MUCOSOPT IMMUNOPOTENTIZERS AND RESULTING FORMULATIONS

Publications (1)

Publication Number Publication Date
CU23404A1 true CU23404A1 (en) 2009-08-04

Family

ID=34777988

Family Applications (1)

Application Number Title Priority Date Filing Date
CU20030270A CU23404A1 (en) 2003-11-19 2003-11-19 NEISSERIA MENINGITIDIS CAPSULAR POLYSACARIDS AS MUCOSOPT IMMUNOPOTENTIZERS AND RESULTING FORMULATIONS

Country Status (3)

Country Link
AR (1) AR046840A1 (en)
CU (1) CU23404A1 (en)
WO (1) WO2005049076A1 (en)

Families Citing this family (24)

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MXPA06001669A (en) 2003-08-12 2006-04-28 3M Innovative Properties Co Oxime substituted imidazo-containing compounds.
US7897597B2 (en) 2003-08-27 2011-03-01 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted imidazoquinolines
WO2005023190A2 (en) 2003-09-05 2005-03-17 3M Innovative Properties Company Treatment for cd5+ b cell lymphoma
US7544697B2 (en) 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
BRPI0414856A (en) 2003-10-03 2006-11-21 3M Innovative Properties Co alkoxy-substituted imidazoquinolines
US8598192B2 (en) 2003-11-14 2013-12-03 3M Innovative Properties Company Hydroxylamine substituted imidazoquinolines
WO2005048933A2 (en) 2003-11-14 2005-06-02 3M Innovative Properties Company Oxime substituted imidazo ring compounds
NZ547467A (en) 2003-11-25 2010-06-25 3M Innovative Properties Co Substituted imidazo ring system and methods
US8802853B2 (en) 2003-12-29 2014-08-12 3M Innovative Properties Company Arylalkenyl and arylalkynyl substituted imidazoquinolines
US8735421B2 (en) 2003-12-30 2014-05-27 3M Innovative Properties Company Imidazoquinolinyl sulfonamides
CA2559863A1 (en) 2004-03-24 2005-10-13 3M Innovative Properties Company Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
WO2005123080A2 (en) 2004-06-15 2005-12-29 3M Innovative Properties Company Nitrogen-containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
US7897609B2 (en) 2004-06-18 2011-03-01 3M Innovative Properties Company Aryl substituted imidazonaphthyridines
WO2006009826A1 (en) 2004-06-18 2006-01-26 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
WO2006065280A2 (en) 2004-06-18 2006-06-22 3M Innovative Properties Company Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and methods
ES2392648T3 (en) 2004-12-30 2012-12-12 3M Innovative Properties Company Substituted chiral compounds containing a condensed 1,2-imidazo-4,5-c core
JP2008526752A (en) * 2004-12-30 2008-07-24 スリーエム イノベイティブ プロパティズ カンパニー Multipath administration of immune response modifier compounds
EP1831226B1 (en) 2004-12-30 2012-08-08 3M Innovative Properties Company Chiral tetracyclic compounds inducing interferon biosynthesis
JP2008530022A (en) 2005-02-04 2008-08-07 コーリー ファーマシューティカル グループ，インコーポレイテッド Aqueous gel formulation containing immune response modifier
US7968563B2 (en) 2005-02-11 2011-06-28 3M Innovative Properties Company Oxime and hydroxylamine substituted imidazo[4,5-c] ring compounds and methods
US7943610B2 (en) 2005-04-01 2011-05-17 3M Innovative Properties Company Pyrazolopyridine-1,4-diamines and analogs thereof
US7943636B2 (en) 2005-04-01 2011-05-17 3M Innovative Properties Company 1-substituted pyrazolo (3,4-C) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases
US7906506B2 (en) 2006-07-12 2011-03-15 3M Innovative Properties Company Substituted chiral fused [1,2] imidazo [4,5-c] ring compounds and methods
CN101785857B (en) * 2010-03-05 2012-09-26 成都安特金生物技术有限公司 Novel pneumococcal conjugate vaccine and preparation method thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002000249A2 (en) * 2000-06-29 2002-01-03 Glaxosmithkline Biologicals S.A. Multivalent vaccine composition

Also Published As

Publication number Publication date
AR046840A1 (en) 2005-12-28
WO2005049076A1 (en) 2005-06-02

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