CU23209A1 - LIVE VACCINE CANDIDATES WITH IMPROVED ENVIRONMENTAL SECURITY INDICES TO IMMUNIZE ORALALLY AGAINST COLERA - Google Patents

LIVE VACCINE CANDIDATES WITH IMPROVED ENVIRONMENTAL SECURITY INDICES TO IMMUNIZE ORALALLY AGAINST COLERA

Info

Publication number
CU23209A1
CU23209A1 CU20030039A CU20030039A CU23209A1 CU 23209 A1 CU23209 A1 CU 23209A1 CU 20030039 A CU20030039 A CU 20030039A CU 20030039 A CU20030039 A CU 20030039A CU 23209 A1 CU23209 A1 CU 23209A1
Authority
CU
Cuba
Prior art keywords
oralally
colera
immunize
present
live vaccine
Prior art date
Application number
CU20030039A
Other languages
Spanish (es)
Inventor
Portal Edith Suzarte
Larranaga Yussuan Silva
Gutierrez Eriel Martinez
Dominguez Karen Marrero
Calzada Rafael Alfredo Fando
Perez Talena Yamile Ledon
Gonzalez Boris Luis Rodriguez
Gomez Javier Campos
Original Assignee
Cnic Ct Nac Investigaciones
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cnic Ct Nac Investigaciones filed Critical Cnic Ct Nac Investigaciones
Priority to CU20030039A priority Critical patent/CU23209A1/en
Priority to AP2005003378A priority patent/AP1724A/en
Priority to RU2005125793/13A priority patent/RU2316587C2/en
Priority to PCT/CU2004/000002 priority patent/WO2004073736A1/en
Priority to MXPA05008774A priority patent/MXPA05008774A/en
Priority to CA2516581A priority patent/CA2516581C/en
Priority to OA1200500234A priority patent/OA13033A/en
Priority to DK04712469T priority patent/DK1614426T3/en
Priority to AT04712469T priority patent/ATE417625T1/en
Priority to BRPI0407668-0A priority patent/BRPI0407668A/en
Priority to US10/546,410 priority patent/US7592171B2/en
Priority to ES04712469T priority patent/ES2319527T3/en
Priority to CNB2004800101011A priority patent/CN100569286C/en
Priority to EP04712469A priority patent/EP1614426B1/en
Priority to DE602004018478T priority patent/DE602004018478D1/en
Priority to JP2006501454A priority patent/JP4495143B2/en
Priority to EC2005005971A priority patent/ECSP055971A/en
Priority to ZA200507021A priority patent/ZA200507021B/en
Publication of CU23209A1 publication Critical patent/CU23209A1/en

Links

Classifications

    • Y02A50/472—

Landscapes

  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente invencion propone nuevas cepas vivas para inmunizar oralmente contra el colera, en las cuales se combinan las dos propiedades mAs importantes que deben poseer las cepas vivas concebidas como agentes vacunales para inmunizar oralmente contra el colera. Una de Éstas propiedades es la de poseer un nivel de reactogenicidad disminuido hasta niveles aceptables, en virtud del empleo de mutaciones ya conocidas y descritas en el arte anterior. La otra propiedad es poseer un mejor índice de seguridad ambiental en virtud de la supresion del gen mshA o mutaciones espontAneas que conduzcan a la ausencia de la fimbria MSHA en la superficie externa de la bacteria y la ausencia del fago VGJfi en su dotacion genÉtica, los cuales, si estuvieran presentes, permitirían la incorporacion y diseminacion del fago CTXfi asistida por VGJfi, objeto de la presente invencion.The present invention proposes new live strains to orally immunize against cholera, in which the two most important properties that live strains conceived as vaccine agents to orally immunize against cholera are combined. One of these properties is to possess a decreased level of reactogenicity to acceptable levels, by virtue of the use of mutations already known and described in the prior art. The other property is to have a better environmental safety index by virtue of the suppression of the mshA gene or spontaneous mutations that lead to the absence of the MSHA fimbria on the outer surface of the bacteria and the absence of the VGJfi phage in its genetic endowment. which, if present, would allow the incorporation and dissemination of phage CTXfi assisted by VGJfi, object of the present invention.

CU20030039A 2003-02-20 2003-02-20 LIVE VACCINE CANDIDATES WITH IMPROVED ENVIRONMENTAL SECURITY INDICES TO IMMUNIZE ORALALLY AGAINST COLERA CU23209A1 (en)

Priority Applications (18)

Application Number Priority Date Filing Date Title
CU20030039A CU23209A1 (en) 2003-02-20 2003-02-20 LIVE VACCINE CANDIDATES WITH IMPROVED ENVIRONMENTAL SECURITY INDICES TO IMMUNIZE ORALALLY AGAINST COLERA
AP2005003378A AP1724A (en) 2003-02-20 2004-02-19 Attenuated strains of vibrio cholerae with improved biological safety features in freeze dried form for oral vaccination
RU2005125793/13A RU2316587C2 (en) 2003-02-20 2004-02-19 Vibrio cholerae ATTENUATED LIVE STRAIN DESIGNATED FOR PRODUCTION OF ORAL VACCINE
PCT/CU2004/000002 WO2004073736A1 (en) 2003-02-20 2004-02-19 Attenuated strains of vibrio cholerae and lyophilised vaccines containing same
MXPA05008774A MXPA05008774A (en) 2003-02-20 2004-02-19 Attenuated strains of vibrio cholerae and lyophilised vaccines containing same.
CA2516581A CA2516581C (en) 2003-02-20 2004-02-19 Attenuated strains of vibrio cholerae with improved biological safety features in freeze dried form for oral vaccination
OA1200500234A OA13033A (en) 2003-02-20 2004-02-19 Attenuated strains of Vibrio cholerae with improved biological safety features in freeze dried form for oral vaccination.
DK04712469T DK1614426T3 (en) 2003-02-20 2004-02-19 Attenuated strains of Vibrio cholerae and lyophilized vaccines containing them
AT04712469T ATE417625T1 (en) 2003-02-20 2004-02-19 ATTENUATED STRAINS OF VIBRIO CHOLERAE AND LYOPHILIZED VACCINES CONTAINING THEM
BRPI0407668-0A BRPI0407668A (en) 2003-02-20 2004-02-19 live attenuated vibrio cholerae strains with improved dry-frozen biosafety features for oral vaccination
US10/546,410 US7592171B2 (en) 2003-02-20 2004-02-19 Vibrio cholerae with improved biological safety features in freeze dried form
ES04712469T ES2319527T3 (en) 2003-02-20 2004-02-19 DAMPED VAPONS OF VIBRIO CHOLERAE AND LIOFILIZED VACCINES CONTAINING THEM.
CNB2004800101011A CN100569286C (en) 2003-02-20 2004-02-19 Vibrio cholera (Vibrio cholerae) attenuated strain of biological safety feature that is used for the lyophilized form of oral vaccination with improvement
EP04712469A EP1614426B1 (en) 2003-02-20 2004-02-19 Attenuated strains of vibrio cholerae and lyophilised vaccines containing same
DE602004018478T DE602004018478D1 (en) 2003-02-20 2004-02-19 WEAKENED STRAINS OF VIBRIO CHOLERAE AND LYOPHILIZED VACCINE CONTAINING THEM
JP2006501454A JP4495143B2 (en) 2003-02-20 2004-02-19 A freeze-dried cholera attenuated strain for oral vaccination with improved biological safety
EC2005005971A ECSP055971A (en) 2003-02-20 2005-08-18 DAMPED VAPONS OF VIBRIO CHOLERAE AND LIOFILIZED VACCINES CONTAINING THEM.
ZA200507021A ZA200507021B (en) 2003-02-20 2005-09-01 Attenuated strains of Vibrio cholerae and lyophilised vaccines containing same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU20030039A CU23209A1 (en) 2003-02-20 2003-02-20 LIVE VACCINE CANDIDATES WITH IMPROVED ENVIRONMENTAL SECURITY INDICES TO IMMUNIZE ORALALLY AGAINST COLERA

Publications (1)

Publication Number Publication Date
CU23209A1 true CU23209A1 (en) 2007-06-20

Family

ID=40091675

Family Applications (1)

Application Number Title Priority Date Filing Date
CU20030039A CU23209A1 (en) 2003-02-20 2003-02-20 LIVE VACCINE CANDIDATES WITH IMPROVED ENVIRONMENTAL SECURITY INDICES TO IMMUNIZE ORALALLY AGAINST COLERA

Country Status (2)

Country Link
CU (1) CU23209A1 (en)
ZA (1) ZA200507021B (en)

Also Published As

Publication number Publication date
ZA200507021B (en) 2007-01-31

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