CU20160142A7 - PHENOLIC COMPOUND AND COMBINATION OF THE SAME WITH A BENZODIAZEPIN FUSED TO 1,4 DIHYDROPIRIDINE FOR THE TREATMENT OF AFFECTIONS OF THE CENTRAL AND VASCULAR NERVOUS SYSTEM - Google Patents
PHENOLIC COMPOUND AND COMBINATION OF THE SAME WITH A BENZODIAZEPIN FUSED TO 1,4 DIHYDROPIRIDINE FOR THE TREATMENT OF AFFECTIONS OF THE CENTRAL AND VASCULAR NERVOUS SYSTEMInfo
- Publication number
- CU20160142A7 CU20160142A7 CUP2016000142A CU20160142A CU20160142A7 CU 20160142 A7 CU20160142 A7 CU 20160142A7 CU P2016000142 A CUP2016000142 A CU P2016000142A CU 20160142 A CU20160142 A CU 20160142A CU 20160142 A7 CU20160142 A7 CU 20160142A7
- Authority
- CU
- Cuba
- Prior art keywords
- central
- treatment
- nervous system
- fused
- dihydropiridine
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
<p>La presente invención se relaciona con Ia Química, Ia Farmacéutica y en particular con Ia obtención de formulaciones a partir de derivados de compuestos fenólicos o polifenólicos y a partir de derivados de compuestos fenólicos o polifenólicos combinados con sistemas tricíclicos del tipo benzodiazepinas fusionadas a derivados de 1,4-dihidropiridinas con acción sobre el Sistema Nervioso Central y Vascular. Estas composiciones farmacéuticas presentan acción GABAérgica, antiglutamatérgica, moduladora de los canales de calcio, mitoprotectora, antioxidante, antiinflamatoria, y antiapoptótica, utilizables en el tratamiento de las enfermedades cardiovasculares, cerebrovasculares, neurodegenerativas, neuropsiquiátricas y neurológicas.</p><p> The present invention relates to Chemistry, Pharmaceutical and in particular to obtaining formulations from derivatives of phenolic or polyphenolic compounds and from derivatives of phenolic or polyphenolic compounds combined with tricyclic systems of the benzodiazepine type fused to derivatives of 1,4-dihydropyridines with action on the Central and Vascular Nervous System. These pharmaceutical compositions have GABAergic, antiglutamatergic, calcium channel modulator, mitoprotective, antioxidant, anti-inflammatory, and antiapoptotic action, usable in the treatment of cardiovascular, cerebrovascular, neurodegenerative, neuropsychiatric and neurological diseases. </p>
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CUP2016000142A CU20160142A7 (en) | 2016-09-27 | 2016-09-27 | PHENOLIC COMPOUND AND COMBINATION OF THE SAME WITH A BENZODIAZEPIN FUSED TO 1,4 DIHYDROPIRIDINE FOR THE TREATMENT OF AFFECTIONS OF THE CENTRAL AND VASCULAR NERVOUS SYSTEM |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CUP2016000142A CU20160142A7 (en) | 2016-09-27 | 2016-09-27 | PHENOLIC COMPOUND AND COMBINATION OF THE SAME WITH A BENZODIAZEPIN FUSED TO 1,4 DIHYDROPIRIDINE FOR THE TREATMENT OF AFFECTIONS OF THE CENTRAL AND VASCULAR NERVOUS SYSTEM |
Publications (1)
Publication Number | Publication Date |
---|---|
CU20160142A7 true CU20160142A7 (en) | 2018-05-08 |
Family
ID=62104049
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CUP2016000142A CU20160142A7 (en) | 2016-09-27 | 2016-09-27 | PHENOLIC COMPOUND AND COMBINATION OF THE SAME WITH A BENZODIAZEPIN FUSED TO 1,4 DIHYDROPIRIDINE FOR THE TREATMENT OF AFFECTIONS OF THE CENTRAL AND VASCULAR NERVOUS SYSTEM |
Country Status (1)
Country | Link |
---|---|
CU (1) | CU20160142A7 (en) |
-
2016
- 2016-09-27 CU CUP2016000142A patent/CU20160142A7/en unknown
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CO2018011927A2 (en) | Phenolic compound and combination thereof with a benzodiazepine fused to 1,4-dihydropyridine for the treatment of central and vascular nervous system conditions | |
ECSP19003773A (en) | HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS | |
PE20181205A1 (en) | NEW SPIRO COMPOUNDS [3H-INDOL-3,2'-PYRROLIDIN] -2 (1H) -ONE AND DERIVATIVES AS INHIBITORS OF MDM2-P53 | |
CL2017002817A1 (en) | Mono or disubstituted indole derivatives as inhibitors of dengue viral replication | |
MX2018013472A (en) | Combination treatment of ocular inflammatory disorders and diseases. | |
CL2018002758A1 (en) | Indoline derivatives substituted as inhibitors of dengue viral replication. | |
CL2018002718A1 (en) | Indoline derivatives substituted as inhibitors of dengue viral replication. | |
SV2018005750A (en) | DERIVATIVES OF INDOL COMPOUNDS REPLACED AS INHIBITORS OF THE VIRIC REPLICATION OF DENGUE | |
CL2017002153A1 (en) | Bicyclic sulfonamide ketone compounds | |
MX2020004338A (en) | Compositions of phosphorylated tau peptides and uses thereof. | |
CL2018002729A1 (en) | Indole derivatives substituted as inhibitors of dengue viral replication. | |
CL2017000742A1 (en) | Mono or disubstituted Indoles as inhibitors of dengue virus replication | |
CL2017001073A1 (en) | 2,4 diamino-quinolia substituted as new anticancer agents | |
PA8675701A1 (en) | NEW DERIVATIVES OF FLUORENE, COMPOSITIONS THAT CONTAIN THEM AND ITS USE | |
CR20150426A (en) | 2,3-BENZODIAZEPINAS BICYCLE AND SPIROCYCLIC REPLACED | |
CL2016000063A1 (en) | New indolizine derivatives, their preparation procedure and the pharmaceutical compositions containing them. | |
CL2018001085A1 (en) | Indolin-2-one derivatives | |
CO2018002204A2 (en) | Antibacterial agents comprising a pyrazine [2,3-b] - [1,4] oxazin-3-one or a related ring system | |
CU20090172A7 (en) | TRICYCLIC AND TETRACYCLIC SYSTEMS WITH ACTIVITY ON THE CENTRAL AND VASCULAR NERVOUS SYSTEM | |
CL2019002583A1 (en) | Dual inhibitors of magl and faah. | |
CR20180368A (en) | RENTING DIHYDROQUINOLINSULFONAMIDE COMPOUNDS | |
CL2018000282A1 (en) | Selected amide of gamma-hydroxybutyric acid and uses thereof in the treatment of alcohol abuse | |
AR101901A1 (en) | TREATMENT OF NEURODEGENERATIVE DISEASES WITH A COMBINATION OF LAQUINIMOD AND FINGOLIMOD | |
CU20160142A7 (en) | PHENOLIC COMPOUND AND COMBINATION OF THE SAME WITH A BENZODIAZEPIN FUSED TO 1,4 DIHYDROPIRIDINE FOR THE TREATMENT OF AFFECTIONS OF THE CENTRAL AND VASCULAR NERVOUS SYSTEM | |
CU20160058A7 (en) | DERIVED FROM BENZODIAZEPINA WITH ACTIVITY ON THE CENTRAL AND VASCULAR NERVOUS SYSTEM |