CU20110042A7 - Molécula inmunogénica que comprende un ligando de invasión dirigido a un receptor resistente a proteasas - Google Patents
Molécula inmunogénica que comprende un ligando de invasión dirigido a un receptor resistente a proteasasInfo
- Publication number
- CU20110042A7 CU20110042A7 CU20110042A CU20110042A CU20110042A7 CU 20110042 A7 CU20110042 A7 CU 20110042A7 CU 20110042 A CU20110042 A CU 20110042A CU 20110042 A CU20110042 A CU 20110042A CU 20110042 A7 CU20110042 A7 CU 20110042A7
- Authority
- CU
- Cuba
- Prior art keywords
- invasion
- protease
- understand
- link
- immunogenic molecule
- Prior art date
Links
- 230000002163 immunogen Effects 0.000 title abstract 2
- 230000009545 invasion Effects 0.000 title 1
- 239000003446 ligand Substances 0.000 abstract 2
- 108090000317 Chymotrypsin Proteins 0.000 abstract 1
- 101000934346 Homo sapiens T-cell surface antigen CD2 Proteins 0.000 abstract 1
- 102000005348 Neuraminidase Human genes 0.000 abstract 1
- 108010006232 Neuraminidase Proteins 0.000 abstract 1
- 241000223960 Plasmodium falciparum Species 0.000 abstract 1
- 102100025237 T-cell surface antigen CD2 Human genes 0.000 abstract 1
- 108090000631 Trypsin Proteins 0.000 abstract 1
- 102000004142 Trypsin Human genes 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 229960002376 chymotrypsin Drugs 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 201000004792 malaria Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000012588 trypsin Substances 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56905—Protozoa
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/002—Protozoa antigens
- A61K39/015—Hemosporidia antigens, e.g. Plasmodium antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/0225—Spirochetes, e.g. Treponema, Leptospira, Borrelia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
- C07K14/445—Plasmodium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/10—Protozoa; Culture media therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/44—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from protozoa
- G01N2333/445—Plasmodium
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
Abstract
Esta invención se refiere a una molécula inmunogénica que comprende una secuencia de aminoácidos contigua de un ligando de invasión de una cepa de Plasmodium falciparum, siendo capaz el ligando de invasión de unirse a un receptor de eritrocitos, siendo la función del receptor resistente a tripsina y neuraminidasa y quimotripsina, en donde, cuando se administra a un sujeto, la molécula es capaz de inducir una respuesta inmune en la cepa. La invención se refiere, además, a composiciones y métodos para el tratamiento de enfermedades tal como la malaria.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9232308P | 2008-08-27 | 2008-08-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
CU20110042A7 true CU20110042A7 (es) | 2012-06-21 |
Family
ID=41720703
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CU20110042A CU20110042A7 (es) | 2008-08-27 | 2011-02-25 | Molécula inmunogénica que comprende un ligando de invasión dirigido a un receptor resistente a proteasas |
Country Status (7)
Country | Link |
---|---|
US (1) | US9134311B2 (es) |
KR (1) | KR101761422B1 (es) |
CN (1) | CN102131521A (es) |
AU (1) | AU2009287420B2 (es) |
BR (1) | BRPI0917331A2 (es) |
CU (1) | CU20110042A7 (es) |
WO (1) | WO2010022452A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201016969D0 (en) * | 2010-10-08 | 2010-11-24 | Genome Res Ltd | Expression system |
US9884101B2 (en) | 2010-11-09 | 2018-02-06 | The Walter And Eliza Hall Institute For Medical Research | Treatment and prevention of malaria |
MY162954A (en) | 2010-11-09 | 2017-07-31 | The Walter And Eliza Hall Inst Of Medical Res | Treatment and prevention of malaria |
GB201103293D0 (en) * | 2011-02-25 | 2011-04-13 | Isis Innovation | Treatment and prevention of malaria |
CN102533678A (zh) * | 2012-01-10 | 2012-07-04 | 特菲(天津)生物医药科技有限公司 | 一种间日疟红内期疫苗及其制备方法 |
CN103965331A (zh) * | 2013-01-29 | 2014-08-06 | 苏州偲聚生物材料有限公司 | 多肽、包含该多肽的检测器件和检测试剂盒 |
CN103965329B (zh) * | 2013-01-29 | 2016-04-13 | 苏州偲聚生物材料有限公司 | 多肽、包含该多肽的检测器件和检测试剂盒 |
CN103965332B (zh) * | 2013-01-29 | 2016-08-10 | 苏州偲聚生物材料有限公司 | 多肽、包含该多肽的检测器件和检测试剂盒 |
GB201413530D0 (en) | 2014-07-30 | 2014-09-10 | Isis Innovation | Treatment and prevention of malaria |
WO2016197190A1 (en) * | 2015-06-09 | 2016-12-15 | The Walter And Eliza Hall Institute Of Medical Research | Structure of plasmepsin v in complex with an inhibitor and uses thereof |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU759144B2 (en) * | 1998-05-05 | 2003-04-03 | Adherex Technologies Inc. | Compounds and methods for modulating nonclassical cadherin-mediated functions |
ES2258932B1 (es) * | 2005-02-25 | 2007-11-16 | Universidad De Barcelona | Sensor radioquimico para fluidos. |
US8128921B2 (en) * | 2006-07-11 | 2012-03-06 | University Of Connecticut | Use of conditional plasmodium strains lacking nutrient transporters in malaria vaccination |
US20090175895A1 (en) * | 2007-11-05 | 2009-07-09 | The Walter And Eliza Hall Institute Of Medical Research | Methods and compositions for treating and preventing malaria |
CA2610100A1 (en) * | 2007-11-05 | 2009-05-05 | The Walter And Eliza Hall Institute Of Medical Research | Methods and compositions for treating and preventing malaria |
US8703147B2 (en) | 2007-11-05 | 2014-04-22 | The Walter And Eliza Hall Institute Of Medical Research | Methods and compositions for treating and preventing malaria (2) |
MY162954A (en) | 2010-11-09 | 2017-07-31 | The Walter And Eliza Hall Inst Of Medical Res | Treatment and prevention of malaria |
-
2009
- 2009-08-27 KR KR1020117006997A patent/KR101761422B1/ko active IP Right Grant
- 2009-08-27 US US13/061,146 patent/US9134311B2/en not_active Expired - Fee Related
- 2009-08-27 WO PCT/AU2009/001099 patent/WO2010022452A1/en active Application Filing
- 2009-08-27 CN CN2009801330858A patent/CN102131521A/zh active Pending
- 2009-08-27 AU AU2009287420A patent/AU2009287420B2/en not_active Ceased
- 2009-08-27 BR BRPI0917331A patent/BRPI0917331A2/pt not_active Application Discontinuation
-
2011
- 2011-02-25 CU CU20110042A patent/CU20110042A7/es unknown
Also Published As
Publication number | Publication date |
---|---|
KR101761422B1 (ko) | 2017-07-25 |
KR20110088497A (ko) | 2011-08-03 |
CN102131521A (zh) | 2011-07-20 |
AU2009287420A1 (en) | 2010-03-04 |
WO2010022452A1 (en) | 2010-03-04 |
US20110311571A1 (en) | 2011-12-22 |
US9134311B2 (en) | 2015-09-15 |
BRPI0917331A2 (pt) | 2015-11-17 |
AU2009287420B2 (en) | 2014-06-12 |
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