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Application filed by Onyx Therapeutics IncfiledCriticalOnyx Therapeutics Inc
Priority to CU20100058ApriorityCriticalpatent/CU20100058A7/en
Publication of CU20100058A7publicationCriticalpatent/CU20100058A7/en
La presente invención se refiere a compuestos ceto-epóxido peptídicos cristalinos, a sus métodos de preparación, y a composiciones farmcéuticas relacionadas. Esta invención también se refiere a métodos para la preparación de ceto-epóxidos aminoacídicos. específicamente, las cetonas arílicas se convierten estereoselectivamente en los ceto-epóxidos deseados.The present invention relates to crystalline peptide keto-epoxide compounds, their methods of preparation, and related pharmaceutical compositions. This invention also relates to methods for the preparation of keto-amino acid epoxides. specifically, aryl ketones are stereoselectively converted to the desired keto-epoxides.
CU20100058A2010-04-052010-04-05
PROTEASE INHIBITORS OF CRYSTALLINE EPOXY KETONE PEPTIDES AND THE SYNTHESIS OF CETO-EPOXIDE AMINO ACIDS
CU20100058A7
(en)
5-((HALOPHENYL)-3-HALO-PYRIDIN-2-YL)-NITRILE DERIVATIVES AS INTERMEDIATES IN THE PREPARATION OF [(5-HALOPHENYL)-3-HYDROXYPYRIDINO-2-CARBONYL)- AMINO]ALKANOIC ACID DERIVATIVES