CU20090151A7 - ADDITION SALTS OF ACID, HYDRATES AND POLYMORPHES OF ETHYL-AMIDA ACID 5- (2,4-DIHIDROXI-5-ISOPROPIL-PHENYL) -4- (4-MORFOLIN-4-IL-METHYL-PHENYL) -ISOXAZOL- 3-CARBOXYL, AND FORMULATIONS THAT UNDERSTAND THESE FORMS - Google Patents

ADDITION SALTS OF ACID, HYDRATES AND POLYMORPHES OF ETHYL-AMIDA ACID 5- (2,4-DIHIDROXI-5-ISOPROPIL-PHENYL) -4- (4-MORFOLIN-4-IL-METHYL-PHENYL) -ISOXAZOL- 3-CARBOXYL, AND FORMULATIONS THAT UNDERSTAND THESE FORMS

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Publication number
CU20090151A7
CU20090151A7 CU20090151A CU20090151A CU20090151A7 CU 20090151 A7 CU20090151 A7 CU 20090151A7 CU 20090151 A CU20090151 A CU 20090151A CU 20090151 A CU20090151 A CU 20090151A CU 20090151 A7 CU20090151 A7 CU 20090151A7
Authority
CU
Cuba
Prior art keywords
phenyl
acid
forms
isoxazol
formulations
Prior art date
Application number
CU20090151A
Other languages
Spanish (es)
Inventor
Weijia Zheng
Holger Petersen
Michael Mutz
Christoph Krell
Brian William Dymock
Martin James Drysdale
Original Assignee
Vernalis R & Amp
D Ltd
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vernalis R & Amp, D Ltd, Novartis Ag filed Critical Vernalis R & Amp
Priority to CU20090151A priority Critical patent/CU20090151A7/en
Publication of CU20090151A7 publication Critical patent/CU20090151A7/en

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Abstract

La presente invención se refiere a nuevas formas de sal etil-amida del ácido 5-(2,4-dihidroxi-5-isopropil-fenil(-4-(4-morfolin-4-il-metil-fenil)-isoxazol-3-carboxílico, en particular la sal de mesilato, clorhidrato, tartrato, fosfato, y hemi-fumarato de la misma; a formas cristalinas de estas sales; a polimorfos de la etil-amida del ácido 5-(2,4-dihidroxi-5-isopropil-fenil(-4-(4-morfolin-4-il-metil-fenil)-isoxazol-3-carboxílico; a hidratos y polimorfos de las nuevas formas de sal mencionadas anteriormente; al uso de las nuevas formas de sal mencionadas anteriormente; para la fabricación de un medicamento para el tratamiento de un trastorno mediado por Hsp90; a un método para el tratamiento de un trastorno mediado por Hsp90, utilizando las nuevas formas de sal; a formulaciones que comprenden estas formas de sal, en particular soluciones acuosas adecuadas para administración intravenosa; y a recipientes de vidrio ámbar que se rellenan con estas formulaciones.The present invention relates to novel forms of 5- (2,4-dihydroxy-5-isopropyl-phenyl (-4- (4-morpholin-4-yl-methyl-phenyl) -isoxazol-3) ethyl-amide salt -carboxylic acid, in particular the mesylate, hydrochloride, tartrate, phosphate, and hemi-fumarate salt thereof; to crystalline forms of these salts; to polymorphs of 5- (2,4-dihydroxy-5 acid ethyl amide) -isopropyl-phenyl (-4- (4-morpholin-4-yl-methyl-phenyl) -isoxazol-3-carboxylic acid; to hydrates and polymorphs of the new salt forms mentioned above; to the use of the new salt forms mentioned above; for the manufacture of a medicament for the treatment of an Hsp90 mediated disorder; to a method for the treatment of an Hsp90 mediated disorder, using the new salt forms; to formulations comprising these salt forms, in particular solutions aqueous suitable for intravenous administration; and amber glass containers that are filled with these formulations.

CU20090151A 2009-08-31 2009-08-31 ADDITION SALTS OF ACID, HYDRATES AND POLYMORPHES OF ETHYL-AMIDA ACID 5- (2,4-DIHIDROXI-5-ISOPROPIL-PHENYL) -4- (4-MORFOLIN-4-IL-METHYL-PHENYL) -ISOXAZOL- 3-CARBOXYL, AND FORMULATIONS THAT UNDERSTAND THESE FORMS CU20090151A7 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CU20090151A CU20090151A7 (en) 2009-08-31 2009-08-31 ADDITION SALTS OF ACID, HYDRATES AND POLYMORPHES OF ETHYL-AMIDA ACID 5- (2,4-DIHIDROXI-5-ISOPROPIL-PHENYL) -4- (4-MORFOLIN-4-IL-METHYL-PHENYL) -ISOXAZOL- 3-CARBOXYL, AND FORMULATIONS THAT UNDERSTAND THESE FORMS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU20090151A CU20090151A7 (en) 2009-08-31 2009-08-31 ADDITION SALTS OF ACID, HYDRATES AND POLYMORPHES OF ETHYL-AMIDA ACID 5- (2,4-DIHIDROXI-5-ISOPROPIL-PHENYL) -4- (4-MORFOLIN-4-IL-METHYL-PHENYL) -ISOXAZOL- 3-CARBOXYL, AND FORMULATIONS THAT UNDERSTAND THESE FORMS

Publications (1)

Publication Number Publication Date
CU20090151A7 true CU20090151A7 (en) 2011-04-26

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Application Number Title Priority Date Filing Date
CU20090151A CU20090151A7 (en) 2009-08-31 2009-08-31 ADDITION SALTS OF ACID, HYDRATES AND POLYMORPHES OF ETHYL-AMIDA ACID 5- (2,4-DIHIDROXI-5-ISOPROPIL-PHENYL) -4- (4-MORFOLIN-4-IL-METHYL-PHENYL) -ISOXAZOL- 3-CARBOXYL, AND FORMULATIONS THAT UNDERSTAND THESE FORMS

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CU (1) CU20090151A7 (en)

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