CU20070274A6 - PROCEDURE TO MODIFY THE SOLUBILITY AND STABILITY OF CYCLOSPORIN A - Google Patents
PROCEDURE TO MODIFY THE SOLUBILITY AND STABILITY OF CYCLOSPORIN AInfo
- Publication number
- CU20070274A6 CU20070274A6 CU20070274A CU20070274A CU20070274A6 CU 20070274 A6 CU20070274 A6 CU 20070274A6 CU 20070274 A CU20070274 A CU 20070274A CU 20070274 A CU20070274 A CU 20070274A CU 20070274 A6 CU20070274 A6 CU 20070274A6
- Authority
- CU
- Cuba
- Prior art keywords
- water
- solubility
- stability
- procedure
- cyclosporin
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Abstract
Procedimiento de obtención de ciclosporina A mediante secado por asperción, modificando su solubilidad en agua y en fluido gastrointestinal con ayuda de un tensoactivo hidrofílico y uso de una mezcla de excipientes como Dextrana y polietilenglicol 4000 para aumentar su estabilidad en agua, contribuyendo a mantenerla estable en agua por más de 24 horas, lo que coadyuva a mejorar la absorción de la misma.Procedure for obtaining cyclosporin A by spray drying, modifying its solubility in water and gastrointestinal fluid with the help of a hydrophilic surfactant and using a mixture of excipients such as Dextrana and polyethylene glycol 4000 to increase its stability in water, contributing to keep it stable in water. water for more than 24 hours, which helps to improve its absorption.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CUP2007000274A CU23892B1 (en) | 2007-12-07 | 2007-12-07 | CYCLOSPORINE MICROENCAPSULATED PHARMACEUTICAL COMPOSITION A |
ARP080105294A AR069578A1 (en) | 2007-12-07 | 2008-12-04 | PHARMACEUTICAL COMPOSITION OF CYCLOSPORIN A AND PROCEDURE TO MODIFY YOUR SOLUBILITY AND STABILITY |
PCT/CU2008/000011 WO2009071034A1 (en) | 2007-12-07 | 2008-12-05 | Pharmaceutical cyclosporine composition and method for altering the solubility and stability thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CUP2007000274A CU23892B1 (en) | 2007-12-07 | 2007-12-07 | CYCLOSPORINE MICROENCAPSULATED PHARMACEUTICAL COMPOSITION A |
Publications (2)
Publication Number | Publication Date |
---|---|
CU20070274A6 true CU20070274A6 (en) | 2011-10-31 |
CU23892B1 CU23892B1 (en) | 2013-04-19 |
Family
ID=40717312
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CUP2007000274A CU23892B1 (en) | 2007-12-07 | 2007-12-07 | CYCLOSPORINE MICROENCAPSULATED PHARMACEUTICAL COMPOSITION A |
Country Status (3)
Country | Link |
---|---|
AR (1) | AR069578A1 (en) |
CU (1) | CU23892B1 (en) |
WO (1) | WO2009071034A1 (en) |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0008785D0 (en) * | 2000-04-10 | 2000-05-31 | Novartis Ag | Organic compounds |
EP1539111A1 (en) * | 2002-08-05 | 2005-06-15 | DSM IP Assets B.V. | Oral dosage forms of water insoluble drugs and methods of making the same |
US20070196396A1 (en) * | 2004-02-11 | 2007-08-23 | Rubicon Research Private Limited | Controlled release pharmaceutical compositions with improved bioavailability |
-
2007
- 2007-12-07 CU CUP2007000274A patent/CU23892B1/en active IP Right Grant
-
2008
- 2008-12-04 AR ARP080105294A patent/AR069578A1/en unknown
- 2008-12-05 WO PCT/CU2008/000011 patent/WO2009071034A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
AR069578A1 (en) | 2010-02-03 |
CU23892B1 (en) | 2013-04-19 |
WO2009071034A1 (en) | 2009-06-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant of patent |