CS690184A3 - Peptides, process of their preparation and pharmaceutical containing thereof - Google Patents
Peptides, process of their preparation and pharmaceutical containing thereofInfo
- Publication number
- CS690184A3 CS690184A3 CS846901A CS690184A CS690184A3 CS 690184 A3 CS690184 A3 CS 690184A3 CS 846901 A CS846901 A CS 846901A CS 690184 A CS690184 A CS 690184A CS 690184 A3 CS690184 A3 CS 690184A3
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- arg
- leu
- ala
- ser
- gln
- Prior art date
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- CKLJMWTZIZZHCS-UHFFFAOYSA-N D-OH-Asp Chemical group OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 abstract 3
- CKLJMWTZIZZHCS-UWTATZPHSA-N D-aspartic acid Chemical group OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 abstract 3
- QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical group C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 abstract 2
- ROHFNLRQFUQHCH-RXMQYKEDSA-N D-leucine Chemical group CC(C)C[C@@H](N)C(O)=O ROHFNLRQFUQHCH-RXMQYKEDSA-N 0.000 abstract 2
- OUYCCCASQSFEME-MRVPVSSYSA-N D-tyrosine Chemical compound OC(=O)[C@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-MRVPVSSYSA-N 0.000 abstract 2
- -1 Asp Chemical compound 0.000 abstract 1
- DCXYFEDJOCDNAF-UWTATZPHSA-N D-Asparagine Chemical group OC(=O)[C@H](N)CC(N)=O DCXYFEDJOCDNAF-UWTATZPHSA-N 0.000 abstract 1
- MTCFGRXMJLQNBG-UWTATZPHSA-N D-Serine Chemical group OC[C@@H](N)C(O)=O MTCFGRXMJLQNBG-UWTATZPHSA-N 0.000 abstract 1
- WHUUTDBJXJRKMK-GSVOUGTGSA-N D-glutamic acid Chemical compound OC(=O)[C@H](N)CCC(O)=O WHUUTDBJXJRKMK-GSVOUGTGSA-N 0.000 abstract 1
- ZDXPYRJPNDTMRX-GSVOUGTGSA-N D-glutamine Chemical compound OC(=O)[C@H](N)CCC(N)=O ZDXPYRJPNDTMRX-GSVOUGTGSA-N 0.000 abstract 1
- HNDVDQJCIGZPNO-RXMQYKEDSA-N D-histidine Chemical compound OC(=O)[C@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-RXMQYKEDSA-N 0.000 abstract 1
- FFEARJCKVFRZRR-SCSAIBSYSA-N D-methionine Chemical compound CSCC[C@@H](N)C(O)=O FFEARJCKVFRZRR-SCSAIBSYSA-N 0.000 abstract 1
- COLNVLDHVKWLRT-MRVPVSSYSA-N D-phenylalanine Chemical compound OC(=O)[C@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-MRVPVSSYSA-N 0.000 abstract 1
- SGCGMORCWLEJNZ-UWVGGRQHSA-N His-His Chemical compound C([C@H]([NH3+])C(=O)N[C@@H](CC=1NC=NC=1)C([O-])=O)C1=CN=CN1 SGCGMORCWLEJNZ-UWVGGRQHSA-N 0.000 abstract 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical group OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 abstract 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
- 125000000393 L-methionino group Chemical group [H]OC(=O)[C@@]([H])(N([H])[*])C([H])([H])C(SC([H])([H])[H])([H])[H] 0.000 abstract 1
- 125000000773 L-serino group Chemical group [H]OC(=O)[C@@]([H])(N([H])*)C([H])([H])O[H] 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 102220067365 rs143592561 Human genes 0.000 abstract 1
- 102220012898 rs397516346 Human genes 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Synthetic peptides of formula (I) and their nontoxic salts are new. R1-R2-R3-Ala- Ile-Phe-Thr-R8- Ser-R10-Arg-R12-R13-Leu-R13-G ln- R17-R18-Ala-Arg- Lys-Leu-R23-R24- R25-Ile-R27-R28-Arg-Gln-Gln-Gly- Glu-R34-Asn-Gln- Glu-R38-R39-R40-Arg-R42-R43-R44 (I) - In (I), R1=Tyr, D-Tyr, Met,Phe, D-Phe, 4-chloro-Phe, Leu, His or D-His, and is opt. C alpha- or Alpha-CH3 substd. R2 = Ala or D-Ala; R3 = Asp or D-Asp; R8 = Ser, Asn, D-Ser or D-Asn; R10= Tyr or D-Tyr; R12 = Arg or Lys; R13= Ile or Val, R15 = Gly or D-Ala; R17 = Leu or D-Leu; R18 = Tyr or Ser; R23 = Leu or D-Geu; R24 = His or Gln; R25 = Glu, Asp, D-Gln or D-Asp; R27 = Met, D-Met, Ala, Nla, Ile, Leu, Nva or Val; R28 = Asn or Ser; R34 = Arg or Ser; R38 = Gln or Arg; R39 = Arg or Gly; R40 = Ser or Ala; R42 = Phe, Ala or Val; R43 = Asn or Arg; R44 = natural amino, and any or all of residues R29 to R44 can be deleted. Proviso are of the following conditions must apply: (I) R1 is alpha-CH3 substd; (2) R17 and/or R23 is D-Leu; (3) R25 is D-Glu or D-Asp.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/545,094 US4518586A (en) | 1983-01-13 | 1983-10-25 | GRF Analogs III |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CS690184A3 true CS690184A3 (en) | 1992-04-15 |
| CS276972B6 CS276972B6 (en) | 1992-11-18 |
Family
ID=24174872
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS846901A CS276972B6 (en) | 1983-10-25 | 1984-09-13 | Peptides, process of their preparation and pharmaceutical containing thereof |
Country Status (1)
| Country | Link |
|---|---|
| CS (1) | CS276972B6 (en) |
-
1984
- 1984-09-13 CS CS846901A patent/CS276972B6/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CS276972B6 (en) | 1992-11-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU578467B2 (en) | GRF Analogs IV | |
| ES8600217A1 (en) | GRF analogs. | |
| DK355889D0 (en) | SYNTHETIC PEPTID AND PHARMACEUTICAL SUBSTANCE CONTAINING PEPTID | |
| ES8506263A1 (en) | GRF analogs. | |
| NO178031C (en) | Analogous Process for Preparing Therapeutically Active Synthetic Peptide Analogs | |
| CS690184A3 (en) | Peptides, process of their preparation and pharmaceutical containing thereof | |
| TH1778A (en) | GRF analogues (GRF) |