CS470587A2 - Method of 4-hydroxypyrrolidine-2-on-1-ylacetamide production - Google Patents
Method of 4-hydroxypyrrolidine-2-on-1-ylacetamide productionInfo
- Publication number
- CS470587A2 CS470587A2 CS874705A CS470587A CS470587A2 CS 470587 A2 CS470587 A2 CS 470587A2 CS 874705 A CS874705 A CS 874705A CS 470587 A CS470587 A CS 470587A CS 470587 A2 CS470587 A2 CS 470587A2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- production
- ylacetamide
- hydroxypyrrolidine
- acetamide
- intermediate product
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- IHLAQQPQKRMGSS-UHFFFAOYSA-N oxiracetam Chemical compound NC(=O)CN1CC(O)CC1=O IHLAQQPQKRMGSS-UHFFFAOYSA-N 0.000 title 1
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 abstract 2
- 239000013067 intermediate product Substances 0.000 abstract 2
- CPMIVIBDTJGVDA-UHFFFAOYSA-N 2-(5-oxo-3-phenylmethoxy-2h-pyrrol-1-yl)acetamide Chemical compound O=C1N(CC(=O)N)CC(OCC=2C=CC=CC=2)=C1 CPMIVIBDTJGVDA-UHFFFAOYSA-N 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/38—2-Pyrrolones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CS891053A CS271493B2 (en) | 1986-06-26 | 1989-02-17 | Method of 4-benzyloxy-3-pyrroline-2-on-1-yl-acetamide production |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH2567/86A CH668424A5 (de) | 1986-06-26 | 1986-06-26 | 4-benzyloxy-3-pyrrolin-2-on-l-yl-acetamid, dessen herstellung und verwendung. |
Publications (2)
Publication Number | Publication Date |
---|---|
CS470587A2 true CS470587A2 (en) | 1990-02-12 |
CS271472B2 CS271472B2 (en) | 1990-10-12 |
Family
ID=4236706
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CS874705A CS271472B2 (en) | 1986-06-26 | 1987-06-24 | Method of 4-hydroxypyrrolidine-2-on-1-ylacetamide production |
Country Status (14)
Country | Link |
---|---|
US (5) | US4849528A (cs) |
EP (1) | EP0252353B1 (cs) |
JP (1) | JPS638368A (cs) |
AT (1) | ATE55985T1 (cs) |
CA (1) | CA1280426C (cs) |
CH (1) | CH668424A5 (cs) |
CS (1) | CS271472B2 (cs) |
DE (1) | DE3764559D1 (cs) |
DK (1) | DK325387A (cs) |
ES (1) | ES2017677B3 (cs) |
HU (1) | HUT44492A (cs) |
IL (1) | IL82937A (cs) |
NO (1) | NO872671L (cs) |
SU (2) | SU1581220A3 (cs) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3835291A1 (de) * | 1988-04-19 | 1989-11-02 | Bayer Ag | 1,3-disubstituierte pyrrolidine |
US5274097A (en) * | 1988-04-19 | 1993-12-28 | Bayer Aktiengesellschaft | 1,3-disubstituted pyrrolidines |
DE58909320D1 (de) * | 1988-09-06 | 1995-08-03 | Lonza Ag | Verfahren zur Herstellung von 5-Alkyltetramsäuren. |
CH680293A5 (cs) * | 1990-06-26 | 1992-07-31 | Lonza Ag | |
JP2001072592A (ja) | 1999-07-01 | 2001-03-21 | Kyowa Hakko Kogyo Co Ltd | テロメラーゼ阻害剤 |
CA2640806A1 (en) * | 2006-04-28 | 2007-11-15 | Laboratorios Del Dr. Esteve, S.A. | Bicyclic tetrahydropyrrole compounds |
CN102432516B (zh) * | 2011-12-14 | 2013-10-09 | 山东阿如拉药物研究开发有限公司 | 奥拉西坦的精制方法 |
CN104276992B (zh) * | 2014-09-17 | 2017-02-15 | 浙江工业大学 | 一种奥拉西坦关键中间体2‑(2,4‑二氧代吡咯烷‑1‑基)‑乙酰胺的合成工艺 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2784191A (en) * | 1957-03-05 | Process for the production of lactams | ||
US2535010A (en) * | 1948-10-02 | 1950-12-19 | Rohm & Haas | Transetherification of beta-ethersubstituted esters |
DE850007C (de) * | 1950-12-22 | 1952-09-22 | Basf Ag | Verfahren zur Herstellung von N-Aryl-ª‡-pyrrolidonen |
US3299095A (en) * | 1964-04-16 | 1967-01-17 | Merck & Co Inc | 1-benzyl tetramic acid derivatives |
JPS4941521A (cs) * | 1972-06-02 | 1974-04-18 | ||
IT1045043B (it) * | 1975-08-13 | 1980-04-21 | Isf Spa | Derivati pirrolidinici |
IT1075564B (it) * | 1977-02-11 | 1985-04-22 | Isf Spa | Procedimento per la preparazione di derivati pirrolidinici |
IT1075280B (it) * | 1977-02-11 | 1985-04-22 | Isf Spa | Procedimento per la preparazione di derivati pirrolidinici |
JPS5812272B2 (ja) * | 1981-04-28 | 1983-03-07 | 電気化学工業株式会社 | 4−ヒドロキシ−2−ピロリドンの製造法 |
FI83510C (fi) * | 1985-02-22 | 1991-07-25 | Ciba Geigy Ag | Foerfarande foer framstaellning av nya, terapeutiskt anvaendbara bi-2h- pyrroli(di)ndioner. |
-
1986
- 1986-06-26 CH CH2567/86A patent/CH668424A5/de not_active IP Right Cessation
-
1987
- 1987-06-10 US US07/060,262 patent/US4849528A/en not_active Expired - Fee Related
- 1987-06-19 CA CA000540292A patent/CA1280426C/en not_active Expired - Fee Related
- 1987-06-21 IL IL82937A patent/IL82937A/xx unknown
- 1987-06-22 DE DE8787108902T patent/DE3764559D1/de not_active Expired - Fee Related
- 1987-06-22 EP EP87108902A patent/EP0252353B1/de not_active Expired - Lifetime
- 1987-06-22 AT AT87108902T patent/ATE55985T1/de not_active IP Right Cessation
- 1987-06-22 ES ES87108902T patent/ES2017677B3/es not_active Expired - Lifetime
- 1987-06-22 JP JP62155254A patent/JPS638368A/ja active Pending
- 1987-06-24 CS CS874705A patent/CS271472B2/cs unknown
- 1987-06-25 HU HU872885A patent/HUT44492A/hu unknown
- 1987-06-25 SU SU874202777A patent/SU1581220A3/ru active
- 1987-06-25 NO NO872671A patent/NO872671L/no unknown
- 1987-06-25 DK DK325387A patent/DK325387A/da not_active Application Discontinuation
- 1987-08-26 SU SU874203180A patent/SU1556537A3/ru active
-
1988
- 1988-04-14 US US07/181,435 patent/US4868314A/en not_active Expired - Fee Related
- 1988-04-14 US US07/181,710 patent/US4879393A/en not_active Expired - Fee Related
- 1988-04-14 US US07/181,646 patent/US4843166A/en not_active Expired - Fee Related
-
1989
- 1989-04-11 US US07/336,070 patent/US4877884A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US4849528A (en) | 1989-07-18 |
ES2017677B3 (es) | 1991-03-01 |
SU1556537A3 (ru) | 1990-04-07 |
HUT44492A (en) | 1988-03-28 |
US4879393A (en) | 1989-11-07 |
ATE55985T1 (de) | 1990-09-15 |
JPS638368A (ja) | 1988-01-14 |
CS271472B2 (en) | 1990-10-12 |
EP0252353B1 (de) | 1990-08-29 |
SU1581220A3 (ru) | 1990-07-23 |
DK325387D0 (da) | 1987-06-25 |
US4843166A (en) | 1989-06-27 |
IL82937A (en) | 1991-03-10 |
NO872671D0 (no) | 1987-06-25 |
CA1280426C (en) | 1991-02-19 |
CH668424A5 (de) | 1988-12-30 |
US4868314A (en) | 1989-09-19 |
EP0252353A1 (de) | 1988-01-13 |
IL82937A0 (en) | 1987-12-20 |
NO872671L (no) | 1987-12-28 |
DE3764559D1 (de) | 1990-10-04 |
US4877884A (en) | 1989-10-31 |
DK325387A (da) | 1987-12-27 |
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