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Application filed by Ustav Organicke Chemie A BiochfiledCriticalUstav Organicke Chemie A Bioch
Priority to CS497489ApriorityCriticalpatent/CS275015B2/en
Publication of CS497489A2publicationCriticalpatent/CS497489A2/en
Publication of CS275015B2publicationCriticalpatent/CS275015B2/en
The prototypes of human insulin, /L-Thr-NH2/<B30> insulin and /L-Thr-NHCH3/<B30> insulin are prepared by the semisynthetic procedure from des-Ala<B30> porcine insulin with the preserved content of zinc during catalysis by trypsin in the medium between 60 and 70 percent by volume of hydrous dimethylformamide in the presence of 10 mmoles dm<-3> of calcium chloride with pH between 7 and 8. Both substances preserve the biological activity identical with human insulin.
CS497489A1989-08-241989-08-24Method of human insulin's analogues preparation
CS275015B2
(en)