CS275015B2 - Method of human insulin's analogues preparation - Google Patents

Method of human insulin's analogues preparation

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Publication number
CS275015B2
CS275015B2 CS497489A CS497489A CS275015B2 CS 275015 B2 CS275015 B2 CS 275015B2 CS 497489 A CS497489 A CS 497489A CS 497489 A CS497489 A CS 497489A CS 275015 B2 CS275015 B2 CS 275015B2
Authority
CS
Czechoslovakia
Prior art keywords
insulin
human insulin
thr
analogues
preparation
Prior art date
Application number
CS497489A
Other languages
Czech (cs)
Other versions
CS497489A2 (en
Inventor
Ivo Rndr Svoboda
Tomas Ing Buchvaldek
Alena Hankeova
Jana Rndr Csc Barthova
Tomislav Rndr Drsc Barth
Original Assignee
Ustav Organicke Chemie A Bioch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ustav Organicke Chemie A Bioch filed Critical Ustav Organicke Chemie A Bioch
Priority to CS497489A priority Critical patent/CS275015B2/en
Publication of CS497489A2 publication Critical patent/CS497489A2/en
Publication of CS275015B2 publication Critical patent/CS275015B2/en

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Abstract

The prototypes of human insulin, /L-Thr-NH2/<B30> insulin and /L-Thr-NHCH3/<B30> insulin are prepared by the semisynthetic procedure from des-Ala<B30> porcine insulin with the preserved content of zinc during catalysis by trypsin in the medium between 60 and 70 percent by volume of hydrous dimethylformamide in the presence of 10 mmoles dm<-3> of calcium chloride with pH between 7 and 8. Both substances preserve the biological activity identical with human insulin.
CS497489A 1989-08-24 1989-08-24 Method of human insulin's analogues preparation CS275015B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CS497489A CS275015B2 (en) 1989-08-24 1989-08-24 Method of human insulin's analogues preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CS497489A CS275015B2 (en) 1989-08-24 1989-08-24 Method of human insulin's analogues preparation

Publications (2)

Publication Number Publication Date
CS497489A2 CS497489A2 (en) 1991-03-12
CS275015B2 true CS275015B2 (en) 1991-12-17

Family

ID=5393680

Family Applications (1)

Application Number Title Priority Date Filing Date
CS497489A CS275015B2 (en) 1989-08-24 1989-08-24 Method of human insulin's analogues preparation

Country Status (1)

Country Link
CS (1) CS275015B2 (en)

Also Published As

Publication number Publication date
CS497489A2 (en) 1991-03-12

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