CS275014B2 - Peptides with accumulated pair of basic amino acids - Google Patents
Peptides with accumulated pair of basic amino acidsInfo
- Publication number
- CS275014B2 CS275014B2 CS497389A CS497389A CS275014B2 CS 275014 B2 CS275014 B2 CS 275014B2 CS 497389 A CS497389 A CS 497389A CS 497389 A CS497389 A CS 497389A CS 275014 B2 CS275014 B2 CS 275014B2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- heptapeptides
- lys
- gly
- arg
- peptides
- Prior art date
Links
- 150000001413 amino acids Chemical class 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 abstract 2
- RDOXTESZEPMUJZ-UHFFFAOYSA-N anisole Chemical compound COC1=CC=CC=C1 RDOXTESZEPMUJZ-UHFFFAOYSA-N 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- 102000005600 Cathepsins Human genes 0.000 abstract 1
- 108010084457 Cathepsins Proteins 0.000 abstract 1
- ODKSFYDXXFIFQN-SCSAIBSYSA-N D-arginine Chemical group OC(=O)[C@H](N)CCCNC(N)=N ODKSFYDXXFIFQN-SCSAIBSYSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-RXMQYKEDSA-N D-lysine Chemical group NCCCC[C@@H](N)C(O)=O KDXKERNSBIXSRK-RXMQYKEDSA-N 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 abstract 1
- JBCLFWXMTIKCCB-UHFFFAOYSA-N H-Gly-Phe-OH Natural products NCC(=O)NC(C(O)=O)CC1=CC=CC=C1 JBCLFWXMTIKCCB-UHFFFAOYSA-N 0.000 abstract 1
- 102000004157 Hydrolases Human genes 0.000 abstract 1
- 108090000604 Hydrolases Proteins 0.000 abstract 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical group OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical group NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
- 239000004793 Polystyrene Substances 0.000 abstract 1
- 235000001014 amino acid Nutrition 0.000 abstract 1
- 229940024606 amino acid Drugs 0.000 abstract 1
- 230000001955 cumulated effect Effects 0.000 abstract 1
- 229910000040 hydrogen fluoride Inorganic materials 0.000 abstract 1
- 229940124280 l-arginine Drugs 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- UZKWTJUDCOPSNM-UHFFFAOYSA-N methoxybenzene Substances CCCCOC=C UZKWTJUDCOPSNM-UHFFFAOYSA-N 0.000 abstract 1
- 229920002223 polystyrene Polymers 0.000 abstract 1
- 239000007790 solid phase Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
By synthesis on solid phase a group of 16 heptapeptides was prepared with cumulated pair of basic aminoacids in position of 4 and 5 of general formulaL-Leu-Gly-L-Val - X - X - Gly-L-Phe,where X is L-Arg, D-Arg, L-Lys or D-Lys and their mutual combination. The above mentioned substances are prepared by gradual formation of peptide chain on chloromethylated polystyrene carrier cross-linked by 1 percent of divinyl benzene and they are released from the carrier by splitting by liquid hydrogen fluoride with addition of 10 percent anisole. Heptapeptides represent a complex system of substances utilizable for characteristics of specific hydrolases from the group of trypsins, cathepsins B and other similar enzymes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS497389A CS275014B2 (en) | 1989-08-24 | 1989-08-24 | Peptides with accumulated pair of basic amino acids |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS497389A CS275014B2 (en) | 1989-08-24 | 1989-08-24 | Peptides with accumulated pair of basic amino acids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CS8904973A1 CS8904973A1 (en) | 1990-12-13 |
| CS275014B2 true CS275014B2 (en) | 1991-12-17 |
Family
ID=5393671
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS497389A CS275014B2 (en) | 1989-08-24 | 1989-08-24 | Peptides with accumulated pair of basic amino acids |
Country Status (1)
| Country | Link |
|---|---|
| CS (1) | CS275014B2 (en) |
-
1989
- 1989-08-24 CS CS497389A patent/CS275014B2/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CS8904973A1 (en) | 1990-12-13 |
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