CS274850B2 - Strain of microorganism brevibacterium flavum ccm 4125 - Google Patents
Strain of microorganism brevibacterium flavum ccm 4125Info
- Publication number
- CS274850B2 CS274850B2 CS335189A CS335189A CS274850B2 CS 274850 B2 CS274850 B2 CS 274850B2 CS 335189 A CS335189 A CS 335189A CS 335189 A CS335189 A CS 335189A CS 274850 B2 CS274850 B2 CS 274850B2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- lysine
- source
- mutant
- brevibacterium flavum
- medium
- Prior art date
Links
- 241000319304 [Brevibacterium] flavum Species 0.000 title abstract 2
- 244000005700 microbiome Species 0.000 title 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 5
- 239000004472 Lysine Substances 0.000 abstract 4
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 3
- 235000018977 lysine Nutrition 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 239000002609 medium Substances 0.000 abstract 2
- UKAUYVFTDYCKQA-UHFFFAOYSA-N -2-Amino-4-hydroxybutanoic acid Natural products OC(=O)C(N)CCO UKAUYVFTDYCKQA-UHFFFAOYSA-N 0.000 abstract 1
- 235000017060 Arachis glabrata Nutrition 0.000 abstract 1
- 241001553178 Arachis glabrata Species 0.000 abstract 1
- 235000010777 Arachis hypogaea Nutrition 0.000 abstract 1
- 235000018262 Arachis monticola Nutrition 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 235000019766 L-Lysine Nutrition 0.000 abstract 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 1
- UKAUYVFTDYCKQA-VKHMYHEASA-N L-homoserine Chemical compound OC(=O)[C@@H](N)CCO UKAUYVFTDYCKQA-VKHMYHEASA-N 0.000 abstract 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 1
- GHSJKUNUIHUPDF-BYPYZUCNSA-N L-thialysine Chemical compound NCCSC[C@H](N)C(O)=O GHSJKUNUIHUPDF-BYPYZUCNSA-N 0.000 abstract 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract 1
- 229930006000 Sucrose Natural products 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 230000000996 additive effect Effects 0.000 abstract 1
- 235000004279 alanine Nutrition 0.000 abstract 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 abstract 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 abstract 1
- 235000011130 ammonium sulphate Nutrition 0.000 abstract 1
- 239000001166 ammonium sulphate Substances 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 230000001955 cumulated effect Effects 0.000 abstract 1
- 235000013681 dietary sucrose Nutrition 0.000 abstract 1
- 235000020776 essential amino acid Nutrition 0.000 abstract 1
- 239000003797 essential amino acid Substances 0.000 abstract 1
- 235000013312 flour Nutrition 0.000 abstract 1
- 239000000413 hydrolysate Substances 0.000 abstract 1
- 230000006698 induction Effects 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 239000003471 mutagenic agent Substances 0.000 abstract 1
- 231100000707 mutagenic chemical Toxicity 0.000 abstract 1
- 230000003505 mutagenic effect Effects 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000001477 organic nitrogen group Chemical group 0.000 abstract 1
- 235000020232 peanut Nutrition 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000006152 selective media Substances 0.000 abstract 1
- 230000035945 sensitivity Effects 0.000 abstract 1
- 229960004793 sucrose Drugs 0.000 abstract 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
The purpose of the solution consists in production of essential aminoacid of lysine, used mainly as a fodder additive. Lysine is synthesized and accumulated in medium by mutant of bacterial strand Brevibacterium flavum, isolated after induction by mutagen using selective media. The mutant, resistant against S-(2-aminoethyl)-L-cysteine, dependant on homoserine, leucine and alanine, in which phagoresistance as well as sensitivity towards fluorpyruvate was detected, cultivated in medium with saccharose as the source of carbon, hydrolysate of peanut flour and corn-steep liquor as the source of organic nitrogen, and ammonium sulphate as the source of inorganic nitrogen and with mineral salts cumulated during conversion 40 percent in aerobic conditions at the temperature of 28 degrees C and neutral pH in the environment 60g/L of L-lysine. The lysine can be produced in this manner using standard technological procedures.<IMAGE>
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS335189A CS274850B2 (en) | 1989-06-02 | 1989-06-02 | Strain of microorganism brevibacterium flavum ccm 4125 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS335189A CS274850B2 (en) | 1989-06-02 | 1989-06-02 | Strain of microorganism brevibacterium flavum ccm 4125 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CS8903351A1 CS8903351A1 (en) | 1991-02-12 |
| CS274850B2 true CS274850B2 (en) | 1991-11-12 |
Family
ID=5373294
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS335189A CS274850B2 (en) | 1989-06-02 | 1989-06-02 | Strain of microorganism brevibacterium flavum ccm 4125 |
Country Status (1)
| Country | Link |
|---|---|
| CS (1) | CS274850B2 (en) |
-
1989
- 1989-06-02 CS CS335189A patent/CS274850B2/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CS8903351A1 (en) | 1991-02-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| IF00 | In force as of 2000-06-30 in czech republic | ||
| MM4A | Patent lapsed due to non-payment of fee |
Effective date: 20050602 |