CS274690B2 - Method of tetrazol's new derivatives production - Google Patents
Method of tetrazol's new derivatives productionInfo
- Publication number
- CS274690B2 CS274690B2 CS276889A CS276889A CS274690B2 CS 274690 B2 CS274690 B2 CS 274690B2 CS 276889 A CS276889 A CS 276889A CS 276889 A CS276889 A CS 276889A CS 274690 B2 CS274690 B2 CS 274690B2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- production
- tetrazol
- alkoxyl
- halogen
- alkyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- CWRVKFFCRWGWCS-UHFFFAOYSA-N Pentrazole Chemical compound C1CCCCC2=NN=NN21 CWRVKFFCRWGWCS-UHFFFAOYSA-N 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- KJUGUADJHNHALS-UHFFFAOYSA-N 1H-tetrazole Substances C=1N=NNN=1 KJUGUADJHNHALS-UHFFFAOYSA-N 0.000 abstract 1
- 102100029077 3-hydroxy-3-methylglutaryl-coenzyme A reductase Human genes 0.000 abstract 1
- 101710158485 3-hydroxy-3-methylglutaryl-coenzyme A reductase Proteins 0.000 abstract 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
- 208000031226 Hyperlipidaemia Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 208000020346 hyperlipoproteinemia Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 150000003536 tetrazoles Chemical class 0.000 abstract 1
- 230000009466 transformation Effects 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The solution concerns a method of production of derivatives of tetrazoles of general formula III, where R<1> and R<4> mean hydrogen, halogen, C1-4-alkyl, C1-4-alkoxyl or trifluoromethyl and R<2>, R<3>, R<4>, R<5> and R<6> mean hydrogen, halogen, C1-4-alkyl or C1-4-alkoxyl. It is characteristic by the fact that alcohol of general formula Ib is subjected to oxidation for transformation of hydroxymethyl group to formyl group. The produced compounds can be used as source substances for production of new inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A-reductase enzyme, which are useful for treatment of hypercholesterolemia, hyperlipoproteinemia and atherosclerosis.<IMAGE>
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1855887A | 1987-02-25 | 1987-02-25 | |
| CS118188A CS274669B2 (en) | 1987-02-25 | 1988-02-24 | Method of tetrazole's new derivatives production |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CS276889A2 CS276889A2 (en) | 1990-11-14 |
| CS274690B2 true CS274690B2 (en) | 1991-09-15 |
Family
ID=25745396
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS276989A CS274691B2 (en) | 1987-02-25 | 1988-02-24 | Method of tetrazol's new derivatives production |
| CS276889A CS274690B2 (en) | 1987-02-25 | 1988-02-24 | Method of tetrazol's new derivatives production |
| CS277089A CS274692B2 (en) | 1987-02-25 | 1988-02-24 | Method of tetrazol's new derivatives production |
| CS277189A CS274693B2 (en) | 1987-02-25 | 1988-02-24 | Method of tetrazol's new derivatives production |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS276989A CS274691B2 (en) | 1987-02-25 | 1988-02-24 | Method of tetrazol's new derivatives production |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS277089A CS274692B2 (en) | 1987-02-25 | 1988-02-24 | Method of tetrazol's new derivatives production |
| CS277189A CS274693B2 (en) | 1987-02-25 | 1988-02-24 | Method of tetrazol's new derivatives production |
Country Status (1)
| Country | Link |
|---|---|
| CS (4) | CS274691B2 (en) |
-
1988
- 1988-02-24 CS CS276989A patent/CS274691B2/en not_active IP Right Cessation
- 1988-02-24 CS CS276889A patent/CS274690B2/en not_active IP Right Cessation
- 1988-02-24 CS CS277089A patent/CS274692B2/en not_active IP Right Cessation
- 1988-02-24 CS CS277189A patent/CS274693B2/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CS277089A2 (en) | 1990-11-14 |
| CS274692B2 (en) | 1991-09-15 |
| CS276889A2 (en) | 1990-11-14 |
| CS276989A2 (en) | 1990-11-14 |
| CS277189A2 (en) | 1990-11-14 |
| CS274693B2 (en) | 1991-09-15 |
| CS274691B2 (en) | 1991-09-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| IF00 | In force as of 2000-06-30 in czech republic | ||
| MM4A | Patent lapsed due to non-payment of fee |
Effective date: 20050224 |