CS274690B2 - Method of tetrazol's new derivatives production - Google Patents

Method of tetrazol's new derivatives production

Info

Publication number
CS274690B2
CS274690B2 CS276889A CS276889A CS274690B2 CS 274690 B2 CS274690 B2 CS 274690B2 CS 276889 A CS276889 A CS 276889A CS 276889 A CS276889 A CS 276889A CS 274690 B2 CS274690 B2 CS 274690B2
Authority
CS
Czechoslovakia
Prior art keywords
production
tetrazol
alkoxyl
halogen
alkyl
Prior art date
Application number
CS276889A
Other languages
Czech (cs)
Other versions
CS276889A2 (en
Inventor
John J Wright
Sing-Yuen Sit
Neelakantan Balasubramanian
Peter J Brown
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Priority claimed from CS118188A external-priority patent/CS274669B2/en
Publication of CS276889A2 publication Critical patent/CS276889A2/en
Publication of CS274690B2 publication Critical patent/CS274690B2/en

Links

Landscapes

  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The solution concerns a method of production of derivatives of tetrazoles of general formula III, where R<1> and R<4> mean hydrogen, halogen, C1-4-alkyl, C1-4-alkoxyl or trifluoromethyl and R<2>, R<3>, R<4>, R<5> and R<6> mean hydrogen, halogen, C1-4-alkyl or C1-4-alkoxyl. It is characteristic by the fact that alcohol of general formula Ib is subjected to oxidation for transformation of hydroxymethyl group to formyl group. The produced compounds can be used as source substances for production of new inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A-reductase enzyme, which are useful for treatment of hypercholesterolemia, hyperlipoproteinemia and atherosclerosis.<IMAGE>
CS276889A 1987-02-25 1988-02-24 Method of tetrazol's new derivatives production CS274690B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1855887A 1987-02-25 1987-02-25
CS118188A CS274669B2 (en) 1987-02-25 1988-02-24 Method of tetrazole's new derivatives production

Publications (2)

Publication Number Publication Date
CS276889A2 CS276889A2 (en) 1990-11-14
CS274690B2 true CS274690B2 (en) 1991-09-15

Family

ID=25745396

Family Applications (4)

Application Number Title Priority Date Filing Date
CS277089A CS274692B2 (en) 1987-02-25 1988-02-24 Method of tetrazol's new derivatives production
CS277189A CS274693B2 (en) 1987-02-25 1988-02-24 Method of tetrazol's new derivatives production
CS276889A CS274690B2 (en) 1987-02-25 1988-02-24 Method of tetrazol's new derivatives production
CS276989A CS274691B2 (en) 1987-02-25 1988-02-24 Method of tetrazol's new derivatives production

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CS277089A CS274692B2 (en) 1987-02-25 1988-02-24 Method of tetrazol's new derivatives production
CS277189A CS274693B2 (en) 1987-02-25 1988-02-24 Method of tetrazol's new derivatives production

Family Applications After (1)

Application Number Title Priority Date Filing Date
CS276989A CS274691B2 (en) 1987-02-25 1988-02-24 Method of tetrazol's new derivatives production

Country Status (1)

Country Link
CS (4) CS274692B2 (en)

Also Published As

Publication number Publication date
CS274692B2 (en) 1991-09-15
CS276989A2 (en) 1990-11-14
CS276889A2 (en) 1990-11-14
CS274693B2 (en) 1991-09-15
CS277089A2 (en) 1990-11-14
CS277189A2 (en) 1990-11-14
CS274691B2 (en) 1991-09-15

Similar Documents

Publication Publication Date Title
EP0783002A3 (en) Process for the preparation of dual action inhibitors
MX9604882A (en) Process for the preparation of dihaloazolopyrimidines.
AU635326B2 (en) A method for cultivating cells in microporous beads
AU7368391A (en) 2,8-dioxabicyclo(3,2,1)octane derivatives and culture of MF5453 for their production and use as antihypercholesterolemics
GB2006248A (en) Preparation of chromogenic pyridine compounds
ES2139189T3 (en) PROCEDURE FOR THE PREPARATION OF DYNAMICS OF CINAMIC ACID.
CS274690B2 (en) Method of tetrazol&#39;s new derivatives production
GR852181B (en)
MY133666A (en) Enzymatic process for stereoselective preparation of therapeutic amides
ATE60330T1 (en) 7-(PHENYLACETAMIDO)-4-ALKYLCUMARINE, PROCESSES FOR THEIR PREPARATION AND THEIR USE IN METHODS FOR THE FLUOROMETRIC DETERMINATION OF THE ACTIVITY OF HYDROLASE, IN PARTICULAR PENICILLIN-G-ACYLASE.
ATE8257T1 (en) PROCESS FOR THE PREPARATION OF 4-QUINOLINONES.
ES2001410A6 (en) Clavam derivatives, preparation and intermediates therefor.
ATE147729T1 (en) ENANTIOMERIC PURE 4,5-DISUBSTITUTED GAMMA-BUTYROLACTAMES, METHOD FOR THEIR PRODUCTION AND THEIR USE
IE880306L (en) Pyridopyrroloquinolines and intermediates thereof
HU913370D0 (en) Process for the production of 8-azabicyclo(3.2.1)octilalkyl-tiazolydinones, the compounds, and medical preparations containing them
ATE157655T1 (en) METHOD FOR PRODUCING OPTIONALLY 2-SUBSTITUTED 5-CHLORIMIDAZOLES
MX9704257A (en) Process for the preparation of 5-(alkoxymethyl) -2,3-pyridinedicarboximide compounds.
ES542810A0 (en) A PROCEDURE FOR THE PREPARATION OF NEW 1- (SUBSTITUTED ARIL) DIHYDRO 1H PIRROLIZIN-3,5- (H, 6H) -DIONAS
ES2031252T3 (en) NEW PROCEDURE FOR OBTAINING ACTIVE NITROSOCARBAMATES.
ES2092968A1 (en) Acyloxylation process for preparing 4-acyloxy-2-azetidinone derivatives
FI944967A (en) Methods for preparing saccharin derivatives and their intermediates useful as proteolytic enzyme inhibitors
MX9601075A (en) Useful reagent and process to graft a substituted trifluoromethyl group onto a compound having at least an electrophilic functional group.
IT1254201B (en) Novel process for the preparation of optically active glycerol derivatives

Legal Events

Date Code Title Description
IF00 In force as of 2000-06-30 in czech republic
MM4A Patent lapsed due to non-payment of fee

Effective date: 20050224