CS274690B2 - Method of tetrazol's new derivatives production - Google Patents
Method of tetrazol's new derivatives productionInfo
- Publication number
- CS274690B2 CS274690B2 CS276889A CS276889A CS274690B2 CS 274690 B2 CS274690 B2 CS 274690B2 CS 276889 A CS276889 A CS 276889A CS 276889 A CS276889 A CS 276889A CS 274690 B2 CS274690 B2 CS 274690B2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- production
- tetrazol
- alkoxyl
- halogen
- alkyl
- Prior art date
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The solution concerns a method of production of derivatives of tetrazoles of general formula III, where R<1> and R<4> mean hydrogen, halogen, C1-4-alkyl, C1-4-alkoxyl or trifluoromethyl and R<2>, R<3>, R<4>, R<5> and R<6> mean hydrogen, halogen, C1-4-alkyl or C1-4-alkoxyl. It is characteristic by the fact that alcohol of general formula Ib is subjected to oxidation for transformation of hydroxymethyl group to formyl group. The produced compounds can be used as source substances for production of new inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A-reductase enzyme, which are useful for treatment of hypercholesterolemia, hyperlipoproteinemia and atherosclerosis.<IMAGE>
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1855887A | 1987-02-25 | 1987-02-25 | |
CS118188A CS274669B2 (en) | 1987-02-25 | 1988-02-24 | Method of tetrazole's new derivatives production |
Publications (2)
Publication Number | Publication Date |
---|---|
CS276889A2 CS276889A2 (en) | 1990-11-14 |
CS274690B2 true CS274690B2 (en) | 1991-09-15 |
Family
ID=25745396
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CS277089A CS274692B2 (en) | 1987-02-25 | 1988-02-24 | Method of tetrazol's new derivatives production |
CS277189A CS274693B2 (en) | 1987-02-25 | 1988-02-24 | Method of tetrazol's new derivatives production |
CS276889A CS274690B2 (en) | 1987-02-25 | 1988-02-24 | Method of tetrazol's new derivatives production |
CS276989A CS274691B2 (en) | 1987-02-25 | 1988-02-24 | Method of tetrazol's new derivatives production |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CS277089A CS274692B2 (en) | 1987-02-25 | 1988-02-24 | Method of tetrazol's new derivatives production |
CS277189A CS274693B2 (en) | 1987-02-25 | 1988-02-24 | Method of tetrazol's new derivatives production |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CS276989A CS274691B2 (en) | 1987-02-25 | 1988-02-24 | Method of tetrazol's new derivatives production |
Country Status (1)
Country | Link |
---|---|
CS (4) | CS274692B2 (en) |
-
1988
- 1988-02-24 CS CS277089A patent/CS274692B2/en not_active IP Right Cessation
- 1988-02-24 CS CS277189A patent/CS274693B2/en not_active IP Right Cessation
- 1988-02-24 CS CS276889A patent/CS274690B2/en not_active IP Right Cessation
- 1988-02-24 CS CS276989A patent/CS274691B2/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CS274692B2 (en) | 1991-09-15 |
CS276989A2 (en) | 1990-11-14 |
CS276889A2 (en) | 1990-11-14 |
CS274693B2 (en) | 1991-09-15 |
CS277089A2 (en) | 1990-11-14 |
CS277189A2 (en) | 1990-11-14 |
CS274691B2 (en) | 1991-09-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
IF00 | In force as of 2000-06-30 in czech republic | ||
MM4A | Patent lapsed due to non-payment of fee |
Effective date: 20050224 |