CS267055B1 - A composition with a biologically most bactericidal activity - Google Patents
A composition with a biologically most bactericidal activity Download PDFInfo
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- CS267055B1 CS267055B1 CS861160A CS116086A CS267055B1 CS 267055 B1 CS267055 B1 CS 267055B1 CS 861160 A CS861160 A CS 861160A CS 116086 A CS116086 A CS 116086A CS 267055 B1 CS267055 B1 CS 267055B1
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- biologically
- bactericidal activity
- tetramethylolglycoluril
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Abstract
Riešenie sa týká použitia tetrametylolglykolurilu vzorca ch2-oh ch2-oh ch2-oh ch2-oh ako prostriedku s biologickou najma baktericídnou aktivitou. Riešenie je možné využiť. pri ochraně materiálov obsahujúcich .trvale alebo přechodné vodu, napr. režných kvapalin, nátěrových hmót, latexov, lepidiel atd.The solution concerns the use of tetramethylolglycoluril of the formula ch2-oh ch2-oh ch2-oh ch2-oh as a means with biological, especially bactericidal activity. The solution can be used. in the protection of materials containing .permanently or transiently water, e.g. cutting fluids, coatings, latexes, adhesives, etc.
Description
2 CS 267 055 Bl
Vynález sa týká použitia tetrametylolglykolurilu (TMGU), ako prostriedku s biologickounajma baktericídnou aktivitou. V poslednom období stúpa záujem o praktická exploatáciu antimikrobiálnych prostriedkov.Uvedené prostriedky je možné rozdělit do nasledujúcich skupin: 1. Formaldehyd uvolňujúce 2. Fenolické deriváty 3. Organosírne - dusík obsahujúce zlúčeniny 4. Róznorodé zlúčeniny 5. Zmesi
Prvú skupinu prostriedkov je možné podlá chemickéj podstaty rozdělit na: a) Triazínové b) Imidazolové c) Hexamínové d) Acetamidové e) Alkánové deriváty Z imidazolových derivátov pozornost vzhladom k Štruktúre si zaslúži haloglykolurilvšeobecného vzorca (H),—-N-C-N-(H),_p o=c (ch2)x c=o (H)l-n-* <"4>n (^1-x (R2)x(R6)q kde x, m, n, p a q = 0 alebo 1, R^ a R£ sú alkyl skupiny a R^, R^, R^ a Rg sú, halogeny. USA pat. č. 3 019 160 popisuje použitie uvedených halogenglykoluri-lov, ako zložiekbaktericídnych kompozícií, k dezinfekoii a bieleniu.
Podlá předloženého vynálezu bolo najdené, že ako prostriedku s biologickou najmS bakte-ricídnou aktivitou možno použit tetrametylolglykolurilu nasledujúceho štruktúrneho vzorca
CHj-OH CH2-OH
ch2-oh ch2-oh CS 267 055 Bl 3
Medzi výhody vynálezu je potřebné predovšetkým zařadit tú skutočnost, že využitím technic-ky a ekonomicky dostupných surovin sa získá účinný baktericídny prostriedok, ktorý sa vyzna-čuje dobrou rozpustnosťou vo vodě, požadovanou stabilitou a lahkou odburatelnostou. Příprava prostriedku spočívá v snadnéj reakcii glykolurilu s formaldehydom podlá schémy:
Izolovaný produkt je biela krystalická látka s teplotou topenia 136,5 °C, ktorá sadosial používá ako sietovač pri výrobě glykoluril - formaldehydových živíc. Ako nová vlastnosttetrametylolglykolurilu bola zistená stálost jeho neutrálnych vodných roztokov pri teplotemiestnosti v rozsahu pH 4,5 až 8,5. Pričom rovnovážné rakcie
>N-CH2-OH ť ·* >NH + HCHO 2 >n-ch2-oh<- > >n-ch2~o-ch2-n < + h2o v tomto rozsahu pH poskytujú cca 0,45 mólov volného formaldehydu/glykoluril. Táto vlastnostdovoluje použit túto látku k novému účelu, a to ako prostriedok s biologickou najma bakteri-cídnou aktivitou.
Tetrametylolglykoluril je možné použit k ochraně režných kvapalín. Vhodný je ako přísadado materiálov obsahujúcich trvale alebo přechodné vodu, napr. do nátěrových hmót, latexov,lepiqfiel, celulózy, preplachovadiel atd. K příslušnému účelu je možné použit surový produkt,bez připadnej izolácie. Na přípravu účinných tekutin popři destilovanéj a demineralizovanejvo^y je možné použit aj vodu pramenitú, pretože přísady solí neznižujú účinok. Aj ked saako rozpúštadlo s výhodou používá vody, bez straty na účinku móže túto funkciu plnit inéi/ozpúštadlo, napr. zriedené roztoky kyselin, zásad, tenzidov, alkoholov, resp. zmes rozpúš-tadiel.
Aplikácia tetrametylolglykolurilu v zmysle předloženého vynálezu nebola v literatúredoposial popísaná a je dokumentovaná nasledujúcim príkladom. Příklad
Pre účinnú zložku baktericídnych prostriedkov tetrametylolglykoluril bola urobenáskúška na biologická aktivitu jednoduchou metodou zón na agarovej póde pre Escheria coli,Pseudomanas aeruginosa a Staphylococcus aureus. V tabulke sú pre koncentrácie 1, 5 a 10 %-nýroztok TMGU uvedené rozměry (0) inhibičných zón.
2 CS 267 055 Bl
The present invention relates to the use of tetramethylolglycoluril (TMGU) as a biological bactericidal activity. Recently, there has been a growing interest in the practical exploitation of antimicrobial agents. The compositions can be divided into the following groups: 1. Formaldehyde releasing 2. Phenolic derivatives 3. Organosulphurous nitrogen containing compounds 4. Greater compounds 5. Mixtures
The first group of agents can be chemically divided into: a) Triazine b) Imidazole c) Hexamine d) Acetamide e) Alkanes Derivatives of the imidazole derivative deserve haloglycoluril (H), - NCN- (H), β o = c (ch 2) x c = o (H) 1 n- * "4> n (1 1-x (R 2) x (R 6) q where x, m, n, p and q = 0 or 1, R i and R6 are alkyl groups and R6, R6, R6 and R8 are, halogens, U.S. Patent No. 3,019,160 discloses the use of said haloglycolurines as component bactericidal compositions for disinfection and bleaching.
According to the present invention, it has been found that tetramethylolglycoluril of the following structural formula can be used as a biologically superior bacterial activity.
CH2-OH CH2-OH
ch2-oh ch2-oh EN 267 055 Bl 3
In particular, the advantages of the invention include the fact that, by utilizing the technically and economically available raw materials, an effective bactericidal composition is obtained which is distinguished by good water solubility, desirable stability and readily degradable. The preparation of the preparation consists in the easy reaction of glycoluril with formaldehyde according to the scheme:
The isolated product is a white crystalline substance having a melting point of 136.5 ° C which is used as a crosslinker in the production of glycoluril formaldehyde resins. The new property of tetramethylolglycoluril was found to be stable in its neutral aqueous solutions at temperature ranges from pH 4.5 to 8.5. With equilibrium rockets
≫ N + HCHO2 > n-ch2-OH < - > n-ch2-o-ch2-n < + h20 within this pH range provide about 0.45 moles of free formaldehyde / glycoluril . This property permits the use of this substance for a new purpose, as a means of biologically superior bacterial activity.
Tetramethylolglycoluril can be used to protect crude liquids. It is suitable as a additive for materials containing permanent or transient water, eg paints, latexes, adhesives, cellulose, flushers, etc. A crude product can be used for the purpose without any isolation. Also, spring water can be used to prepare effective liquids in distilled and demineralized form, since the salt additives do not reduce the effect. Although water is preferably used as the solvent, other functions can be used to perform this function without loss of action, e.g., dilute solutions of acids, bases, surfactants, alcohols, and the like. a mixture of solvents.
The application of tetramethylolglycoluril within the meaning of the present invention has not been described in the literature and is illustrated by the following example. Example
For the active ingredient bactericidal compositions tetramethylolglycoluril, biological activity was tested by a simple agar zone method for Escheria coli, Pseudomanas aeruginosa and Staphylococcus aureus. In the table, for TMGU 1, 5 and 10% concentrations, the dimensions (0) of the inhibition zones are given.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS861160A CS267055B1 (en) | 1986-02-19 | 1986-02-19 | A composition with a biologically most bactericidal activity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS861160A CS267055B1 (en) | 1986-02-19 | 1986-02-19 | A composition with a biologically most bactericidal activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CS116086A1 CS116086A1 (en) | 1989-05-12 |
| CS267055B1 true CS267055B1 (en) | 1990-02-12 |
Family
ID=5345267
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS861160A CS267055B1 (en) | 1986-02-19 | 1986-02-19 | A composition with a biologically most bactericidal activity |
Country Status (1)
| Country | Link |
|---|---|
| CS (1) | CS267055B1 (en) |
-
1986
- 1986-02-19 CS CS861160A patent/CS267055B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CS116086A1 (en) | 1989-05-12 |
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