CS264081B1 - Analgetic agent with anxiolytic - Google Patents

Abstract

Analgesic and anxiolytic effect containing diazepam, ibuprofen or paracetamol and optionally an addition caffeine. The preparation is suitable for treatment of all painful conditions.

Description

The invention relates to an analgesic preparation having an enhanced enolgesic effect on the basis of a combination of an analgesic with an anxiolytic,

It is estimated that 3 to 15% of the population suffers from chronic or periodic axes of recurrent pain, the cause of which is unclear or known but cannot be eliminated once. These people more or less permanently nobo in frequently repeated episodes use aralgesics. c- tea xeiv ac x ty xc-o 2icyx obochujici r; Ar.y / .ccfin _with nee {mm o eufisinue, cofisin, i dnagon ih e eobbitalut:!, Codeinum tibyrogenphcopboricum), Attempt to exclude from these combinations substances with toxic side effects (phenacetin, aminophenazone) and substances where there is a risk of developing dependence (barbituretes, kedoin) led to the emergence of a new type of combination products composed of anslgetika (paracstsmol, kyrii15), nk, t:

'I - ^R / ..... i' * ¹ him and mild anxiolytic activity (Ataralgin comprising paracetamol, caffeine base and guaiphenesinum, Guajanal containing paracetamol and guaiphenesinum). This innovation has been an undisputed advance and the growing need for these drugs has confirmed the results of their clinical trial showing their therapeutic benefits. Yet these new drug combinations have not led to the desirable major departure from Alnagon-type drugs, whose consumption continued to increase and the situation eventually required radical administration. a prescriptive intervention by which the dispensing of this drug was bound by a prescription.

Chronic or frequently recurring pain with water to develop. In syndrome, in whose symptonatology it is sometimes difficult to distinguish whether the subjectively experienced and described bolert is more of anxiety than an expression of organic spice. This is more difficult and difficult to distinguish in the case of psychogonial pain.

264 081

Although the physician's task remains to improve the diagnosis of these conditions and find and then treat the cause, at least it is not yet possible to ignore the fact that this is not always the case in practice. This failure is contributing to the increase in the number of people who have their troubles resolved by regular use of combined analgesic medications that are prescribed by their physicians or which they obtain without a prescription. Research in recent years has shown that these drugs are often abused as day-to-day doping and, in fact, are more stimulating than analgesic in chronic use.

The main advantage of the formulation according to the invention is the increased therapeutic efficacy and the ease of use of drugs. Chronic algic syndromes often suffer from older people, who also have multiple nomotics (polymorbidity) and often use more types of drugs. The multiplication of this number is associated with the risk of poor compliance. The combination of anxiolytic and analgesic in one dosage form, eg a tablet, is a significant advance, often it is not easy to convince a patient to take a psychopharmacone or another drug declared as psychopharmacone. Especially ill and with Algl syndrome, he often begins to think that the doctor thinks that he or she simulates his pain **.

The improvement of the already established route by combining an analgesic-ontipyretic with an anxiolytic can be achieved by using a highly effective anxiolytic-myorelaxant diazepam, which additionally has a sedative effect, instead of a moderately effective guaifenesin. The main indication areas of such a combination drug are acute pain syndromes associated with pathology of the spine (discogenous syndromes, lumboischiatic syndromes, cephalgia associated with cervical spine changes, etc.), increased muscle tone and muscle spasms.

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The major risk of such a drug could be drug dependence. This could be prevented by prescription and doctors instructed that it should not be administered for more than 3 to 4 weeks. The acute pain syndromes for which this drug ^{1 is} indicated can usually be managed within 5 to 10 days.

This disadvantage is more than counterbalanced by the appropriate potentiating effect of the anti-inflammatory analgesic and the highly potent anxiolytic myorelaxant. Oak known psychic tension also leads to an increase in muscle tone (this is clearly evident in the facial expression), which results in pain.

The first step is a composition of the invention comprising a combination of 2 to 10 parts by weight of diazepam and 200 to 600 parts by weight of ibuprofen, or 325 to 500 parts by weight of paracetamol. Optionally, the composition may further comprise 20 to 100 parts by weight of caffeine.

The composition of the invention may be formulated into conventional dosage forms such as tablets, etc.

The following examples serve to illustrate the preparation according to the invention and do not limit the scope of the invention in any way.

Example 1 diazepam 3 mg ibuprofen 200 mg

Example 2 Diazepam Paracetamol

Claims (2)

SUBJECT OF THE INVENTION 264 081 An analgesic preparation with anxiolytic, characterized by: It comprises from 2 to 10 parts by weight of diazepam, optionally in the form of a pharmaceutically acceptable eoli, and from 200 to 600 parts by weight of ibuprofen or 325 to 500 parts by weight of paracetamol. 2. The analgesic composition of claim 1, wherein the composition comprises 20 to 100 parts by weight of caffeine.