CS233969B1 - Tooth paste - Google Patents

Abstract

Toothpaste, intended especially for application in chronic forms of periodontal diseases, containing as active ingredients ethanolic extract of rapeseed (Herba Agrimoniae), chamomile flower (Flos Chamamillae), sage (Herba Salviae) and cinquefoil root (Radix Tormentillae). It also contains calcium pantothenate or panthenol, disinfectants of the higher quaternary ammonium salt type and a physiologically harmless ionic surfactant of the sodium lauryl ether sulfate type.

Description

The invention relates to a toothpaste intended primarily for application in chronic forms of periodontal disease, which, as is known, is among the most common diseases of the oral cavity. For example, a significant proportion of the population, not only middle-aged and older, but more recently also the younger generation, suffers from periodontal disease. So far, it has not been possible to discover a causal treatment for this disease. Symptomatic treatment is partially successful thanks to means that have been developed on the basis of new knowledge and experience and whose effectiveness and quality are constantly increasing. For example, means for massaging periodontal gums /čs*a.o*č· 202 753/ in liquid, gel or pasty form, containing astringent, disinfectant and/or locally anesthetic active substances, or toothpaste intended for regular application, containing, for example, lysozyme, non-ionic detergent, polyethylene glycol and boric acid /SU 623 555? DT 2 445 676; SV 556 675/ or alcoholic extract of sage and calcium glycerophosphate. Various liquid preparations containing vegetable tannins and local anesthetics /benzocaine, procaine, cinchocaine, etc./ are also used, which serve as part of the complex treatment of catarrhal chronic gingivitis.

The aim of the invention was to develop a toothpaste that would effectively serve daily dental care and at the same time have a therapeutic effect in the aforementioned chronic forms of periodontal diseases. Based on long-term research into toothpastes and previous experience with formulas for gel and liquid preparations against periodontal disease, we managed to find a suitable combination and ratio of active ingredients and excipients in a toothpaste preparation intended for daily treatment of periodontal disease, with the aim of reducing tooth loss as much as possible, preventing bleeding gums and removing purulent deposits.

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The invention therefore relates to a toothpaste intended especially for application in chronic forms of periodontal diseases, containing astringent, disinfectant and/or locally anaesthetic active ingredients, in an aqueous or anhydrous gel base, containing surfactants, abrasives, thickeners, stabilisers, flavourings, colourings, perfumes and/or preservatives. The essence of the invention lies in the fact that the paste contains as active ingredients 2.0 to 8.0% by weight, preferably 5.0% by weight, of an ethanolic extract containing in 100 ml the active substance from 4 to 6 g of horsetail /Herba Agrimoniae/, 1.5 to 2.5 g of chamomile flower /Plos Ohamomillae/, 1.5 to 2.5 g of sage /Herba Salviae/ and 0.5 to 1.5 g of cinquefoil root /Radix Tormentillae/, 0.2 to 0.7% by weight, preferably 0.5% by weight, of calcium pantothenate or panthenol, 0.1 to 1.0% by weight, preferably 0.5% by weight, of a disinfectant of the higher quaternary ammonium salt type, preferably carbethoxypentadecyltrimethylammonium bromide, and 1.5 to 5.5% by weight, preferably 5.0% by weight, of a physiologically harmless ionic surfactant of the sodium lauryl ether sulfate type.

Ethanolic extract from medicinal plants in the form of a standardized concentrate forms the basic ingredient in toothpaste with an astringent, deodorizing and antiphlogistic effect.

The composition was selected based on tests with many variations of medicinal plants and their quantities.

Calcium pantothenate or panthenol has a beneficial effect on the epithelialization of injured or inflamed gum tissue and thus promotes granulation.

A disinfectant of the higher quaternary ammonium salt type enables easier cleaning of purulent foci of diseased periodontal tissue and maintains the oral cavity in an ‘optimal microbiological state.

The ionic surfactant used, with its surface-active effect, supports the action and contact of all active ingredients with the entire oral cavity and especially with areas affected by gingivitis.

When formulating the toothpaste according to the invention, it was necessary to ensure a balanced effect of all active ingredients, and in particular to ensure that the astringent effect of the plant extract was not too strong; otherwise, the tissues would be closed so much that the disinfectant component could not act deeply /US 4,159,516/.

The toothpaste according to the invention represents a stable, high-quality and low-cost preparation. Raw materials, both basic and auxiliary, were selected so that the paste had a medium abrasive ability and demonstrable medicinal effects. Through a series of tests, suitable types of gelling agents and thickeners were further selected, preventing sedimentation of the suspension system, such as hydroxyethyl cellulose, colloidally dispersed silicon dioxide, carboxy methyl cellulose or polyethylene glycol 1000. The same considerations applied to the selection of other components, i.e. fillers and abrasives /calcium carbonate, titanium dioxide, etc./.

Selected types of toothpaste according to the invention were tested using climate-technological stability tests run for similar pharmaceutical preparations to verify whether the preparation complies with the requirements of ČSN 68 1505 in terms of its properties. The therapeutic efficacy of the toothpaste according to the invention was evaluated with favorable results at several selected dental clinics.

The toothpaste is produced using raw materials common in cosmetic, dermatological and pharmaceutical practice, meeting the requirements of relevant standards. The production can be carried out using conventional technology without any special requirements for equipment and personnel.

The following exemplary embodiments show several possible toothpaste formulations according to the invention, without limiting these formulations to the described options.

Example 1

In all examples, the amounts of individual components are given in weight percentages. Demineralized or distilled water, which is sterilized, is always used.

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Composition:

Hydroxyethylcellulose 1,200

Glycerin 26,000

Water 16.375

Precipitated calcium carbonate 40,000

Titanium Dioxide 1,000

Plant extract 8,000

Panthenol 0.500

Carethopendecinium bromide 0.500

Saccharin 0.025

Sodium lauryl ether sulfate 5,000

Perfume 1,400

Example 2

Composition:

Colloidally dispersed silicon dioxide 6,000

Glycerin 75,500

Water 2.575

Precipitated calcium carbonate 5,000

Titanium dioxide 0.500

Plant extract 4,000

Calcium pantothenate 0.400

Carethopendecinium bromide 0.200

Saccharin 0.025

Sodium lauryl ether sulfate 2,000

Perfume 1,800

p-Hydroxy-0.200 benzoic acid methyl ester

Foaming agent 1,800

Example 3

Composition:

Carboxymethylcellulose 0.800

Glycerin 20,000

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Water 25.775

Precipitated calcium carbonate 40,000

Titanium Dioxide 1,000

Plant extract 5,000

Panthenol 0.500

Carbethopendecinium bromide 0.500

Saccharin 0.025

Sodium lauryl ether sulfate 5,000

Perfume and/or onion flavoring 1,400

Example 4

Composition:

Colloidally dispersed silicon dioxide 6,000

Polyethylene glycol 1000 17,000

Glycerin 38,000

Paraffin oil 13,700

Calcium carbonate 10,000

Titanium Dioxide 3,000

Plant extract 5,000

Calcium pantothenate 0.500

Carbethopendecinium bromide 0.500

Sodium lauryl ether sulfate 5,000

Perfume 1,300

Example 5

Composition:

Carboxyvinyl polymer 1,000

Propylene glycol 5,000

Glycerin 58,000

Paraffin oil 1,000

Triethanolamine 1,000

Water ' 7,000

Calcium carbonate 12,000

Titanium Dioxide 3,000

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Plant extract 5,000 Panthenol 0.500 Carbethopendeoinium bromide 0.500 Sodium lauryl ether sulfate 5,000 Perfume 1,000

Example 6

Composition

Hydroxyethylcellulose 1,500 Colloidally dispersed oxide 2,000 silica Glycerin 25,000 Water 24,775 Calcium carbonate 23,000 Dicalcium phosphate 8,000 Titanium dioxide 3,000 Plant extract 5,000 Panthenol 0.500 Carbethopendecinium bromide 0.500 Saccharin 0.025 Sodium lauryl ether sulfate 5,000 Perfume 1,700

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Claims (4)

1.5 to 5.5 wt. physiologically harmless ionic surfactant of the sodium salt of lauryl ether sulfate. 1.5 g of mud root (cadix Sormentillae), further 0.2 to 0.7 wt. % calcium pantothenate or panthenol, 0.1 to 1.0 wt. high quaternary ammonium salt disinfectants; and Toothpaste, intended in particular for the application in chronic forms of periodontal diseases, containing adatringing, disinfecting and / or locally anesthetically active ingredients, in an aqueous or non-aqueous gel base which contains surfactants, abrasives, thickeners, stabilizers, flavoring agents, coloring agents, perfume and / or preservatives, characterized in that the active ingredient comprises 2.0 to 8.0 wt. ethanolic extract, containing in 100 ml of active substance from 4 to 6 g of agrimony (Herba Igrimoniae), 1,5 to 2,5 g of chamomile (Tloa Ohamomillae), 1,5 to 2,5 g of sage (Herba Salviae) and 0 , 5 to 2. A toothpaste according to claim 1, comprising 5.0 wt. ethanolic extract of active substances. 3. Toothpaste according to claim 1, characterized in that it contains 0.5 wt. calcium pantothenate or panthenol. 4. The toothpaste of claim 1, wherein said toothpaste comprises 0.5 wt. carbethoxypentadecyltrimethylammonium bromide. _t 5 · The toothpaste according to claim 1, characterized in that it contains 5.0 wt them. physiologically harmless ionic surfactant of the sodium salt of lauryl ether sulfate.