CS232230B1 - Ceramic mass based on hydroxilapatite and oxihyldroxilapatite for implants and natural fixation - Google Patents
Ceramic mass based on hydroxilapatite and oxihyldroxilapatite for implants and natural fixation Download PDFInfo
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- CS232230B1 CS232230B1 CS83114A CS11483A CS232230B1 CS 232230 B1 CS232230 B1 CS 232230B1 CS 83114 A CS83114 A CS 83114A CS 11483 A CS11483 A CS 11483A CS 232230 B1 CS232230 B1 CS 232230B1
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Abstract
Vynález aa týká novej keramickej hmoty pre implantáty a prirodzenou fixáciou. Podetata keramickej hmoty podlá vynálezu spočívá v tom, že obaahuje 40 až 58 % hmotnoatných kysličníka vápenatého a kysličník fosforečný do celkového množstve 100 % hmotnoatných. Keramická hmota na báze hydroxilapatitu a oxihydroxilapatitu pre implantáty a prirodzenou fixáciou podlá vynálezu je biologicky aktívna, elektricky neutrálna, chemicky stála a z hladiska chemického zloženia a morfologie je jej átruktúra podobná kostnému tkanivu. Má póry o velkosti 1 až 3/im^, do ktorých vraatá kostné tkanivo, a tým sa dosiahne teanejšie apojenie medzi koalou a implantátom.The invention aa relates to a new ceramic material for implants and natural fixation. The feature of the ceramic mass according to the invention is that it contains 40 to 58% by weight of calcium oxide and phosphorous oxide in a total amount of 100% by weight. The ceramic material based on hydroxylapatite and oxyhydroxyapatite for implants and natural fixation according to the invention is biologically active, electrically neutral, chemically stable, and in terms of chemical composition and morphology, its structure is similar to bone tissue. It has pores with a size of 1 to 3/im^, into which the bone tissue returns, and thus a tighter connection between the koala and the implant is achieved.
Description
232 230232 230
Vynález ea týká keramickej hmoty na báze hydroxilapati-tu a oxihydroxilapatitu pře implantáty s prirodzenou fixá-ciou.The invention and the invention relates to a hydroxilapathic-based ceramic composition and to oxihydroxilapatite via natural fixation implants.
Implantáty doteraz používané v medicíně boli vyhotovenéz kovu, zo zliatin talia, titanu a tantalu, leh nevýhodou jevodivost elektrického prúdu, Okrem toho majú ešte ďalšiu ne-výhodu - nemožnost dlhodobého prirodzeného mechanického pri-pojenia ku kostnému tkanivu, ďalej často spósobujú zápal,The implants used so far in medicine have been made of metal, tall alloys, titanium and tantalum, the disadvantage of electrical current conductivity. In addition, they have yet another disadvantage - the impossibility of long-term natural mechanical attachment to bone tissue, often causing inflammation,
NajnovŠie výskumné práce s keramickou hmotou naznačujúprirodzenú fixáciu implantátu, Vrastanie kostného tkaniva doporov keramiky vytvára pevnú medzivrstvu pre klinickú aplikáciu implantátov z keramiky, Zistilo sa, že keramika na bázehydroxilapatitu je najvýhodnejšia hlavně preto, lebo z hle-diska chemického zloženia, morfologie a Struktúry je podobnákostnému tkanivu.Recent research work on ceramics suggests native implant fixation. Bone tissue ingrowth of ceramic pores creates a solid interlayer for the clinical application of ceramics implants. Hydroxilapatite based ceramics have been found to be most advantageous because of the similarity in chemical composition, morphology, and structure tissue.
Minerál hydroxilapatit prvý krát syntetizoval P, W. Ar-nold v r, 1950 z fosforečnanu amonného hydrotermálnym spóso-bom. D, M, Ray a S, K. Linneham v r, 1947 připravili hydro-xilapatit z prírodných korálových vápencov, neskór v r. 1975už z kryštalického aragonitu, Uvedené práce riedia přípravuhydroxilapatitu syntézou z prírodných zlúčenín, Hydroxilapa-tit z prírodných vápencov obsahuje medzi stopovými prvkami -2- 232 230 najma stroncium, připadne jeho izotopy· δο značné komplikujejeho použitie pre implantačné účely, lebo uvedené stopovéprvky sú karcinogénne.Hydroxilapatite mineral was first synthesized by P, W. Arnold in 1950 from ammonium phosphate by hydrothermal coupling. D, M, Ray and S, K. Linneham in 1947, prepared hydro-xilapatite from natural coral limestones, necrosis in 1975, from crystalline aragonite, The above works dilute the preparation of hydroxilapatite by synthesis from natural compounds; in particular, strontium, its isotopes · δο significant complications for implantation purposes, since these trace elements are carcinogenic.
Uvedené nevýhody v podstatnéj miere odstraňuje keramic-ká hmota na báze hydroxilapatitu a oxihydroxilapatitu preimplantanty s prirodzenou fixáciou, ktorej podstata spočíváv tom, že obsahuje 40 až 58 % hmotnostných kysličníka vápe-natého a kysličník fosforečný do celkového množstva 100 %hmotnostných. Keramická hmota podl’a vynálezu bola připravenázo syntetických zlúčenín o p<> a. čistotě.The aforementioned disadvantages are substantially eliminated by the ceramics based on hydroxilapatite and oxihydroxilapatite with natural fixation implants, which comprise from 40 to 58% by weight of calcium oxide and phosphorus pentoxide to a total of 100% by weight. The ceramics according to the invention were prepared by synthetic compounds having a purity.
Identifikácia apatitovej keramiky sa potvrdila rtg dia-gramom. Chemické zloženie keramiky bolo robené na rontgeno-vom mikroanalyzátore. Výsledky zloženia sú uvedené v přilo-žené j tabulke. Poměr Ca : P je P : 6.Identification of apatite ceramics was confirmed by X-ray slide. The chemical composition of the ceramic was made on a X-ray microanalyzer. The composition results are shown in the attached table. The Ca: P ratio is P: 6.
Keramická hmota pře implantanty s prirodzenou fixácioupodl’a vynálezu je biologicky aktívna, elektricky neutrálna,chemicky stála a z hladiska chemického zloženia a morfologieje jej Struktúra podobná kostnému tkanivu. Má póry o velkos-ti 1 až JjWm , do ktorých vrasta kostné tkanivo, a tým sadosiahne tesnejSie spojenie medzi kosťou a implantátom. Příklad Východiskové zlúčeniny pre přípravu hydroxilapatitu a oxihy-droxilapatitu sú dusičnan vápenatý a dihydrofosforečnan sod-ný. Připravili aa roztoky týchto zlúčenín o pH = 7,4, potomsa roztoky zmieSali za vyzražania fosforečnanu vápenatého.Vzniknutá zrazenina bielej farby sa vyznačovala velkou jem-nosťou Častíc fosforečnanu vápenatého. Vysušená látka sa po-tom kalcinovala a tavila v rozmedzí tepldt 850 až'l 450 °C.Vzniklý oxihydroxilapatit a hydroxilapatit mal póry o velkosti 1 až $ puč ·The ceramic fixture of the natural fixation method of the invention is biologically active, electrically neutral, chemically stable, and its structure similar to bone tissue in terms of chemical composition and morphology. It has pores of 1 to 1 µm in which bone tissue grows, thereby providing a closer connection between bone and implant. EXAMPLE Starting compounds for the preparation of hydroxilapatite and oxyhydroxilapatite are calcium nitrate and sodium dihydrogen phosphate. Preparations and solutions of these compounds at pH = 7.4, followed by mixing the solutions to precipitate calcium phosphate. The resulting white precipitate was characterized by a large particle size of calcium phosphate particles. The dried substance was then calcined and melted in the range of 850 to 450 ° C. The resulting oxihydroxilapatite and hydroxilapatite had pores of 1 to $ coup.
Fosforečnan vápenatý 232 230Calcium phosphate 232 230
Vzorkač. 2 CaO /hm.%/ P2O5/hme%/ Spolu /hm.%/ Ca5/PO4/3 1 55,2013 44,9669 100,1683 Ca4.60P2.95°12 2 54,9930 43,2818 98,2748 Ca4.69P2.92°12 3 55,3589 43,1226 98,4815 Ca4.72P2o91°12 4 54,6973 44,0917 98,789ο C?4.63P2.95°12 5 55,5689 44,5602 100,1291 Ca4o64P2,94°12 6 55,3444 45,4382 100,7825 Ca4o58P2.97°12 7 55,1389 41,0194 96,1583 Ca4o86P2o85°I2Vzorkač. 2 CaO /hm.// P2O5 / hme% / Total / Wt% / Ca5 / PO4 / 3 1 55.2013 44.9669 100.1683 Ca4.60P2.95 ° 12 2 54.9930 43.2818 98.2748 Ca4.69P2.92 ° 12 3 55.3589 43.1226 98.4815 Ca4.72P2O91 ° 12 4 54.6973 44.0917 98.789ο C? 4.63P2.95 ° 12 5 55.5689 44.5602 100.1291 Ca4o64P2 , 94 ° 12 6 55.3444 45.4382 100.7825 Ca4o58P2.97 ° 12 7 55.1389 41.0194 96.1583 Ca4o86P2o85 ° I2
Zlúčenina hydro - oxihydroxilapatitu mala po přepočte násle-dovně zloženie:The hydro-oxihydroxilapatite compound had the following composition after recalculation:
Vzorkač. 1 CaO /hm.%/ P2O5 /hm.%/ Spolu /hm.%/ Přepočetna atomy Ca 3.195 1 55,944 43,244 99,188 P 1.922 0 8.000 - Ca 3.219 2 56,279 42,933 99,212 P 1.912 0 8.000 Ca 3.290 3 56,106 41,20a 97,314 P 1.884 0 8.000 Ca 3.234 4 56,430 42,710 99,140 P 1.906 0 8.000 Ca 3.226 5 57,117 42,786 99,903 P 1.906 0 8*000 Ca 3.199 6 57,299 43,538 100,837 P 1.921 0 8.000Vzorkač. 1 CaO /hm.%/ P2O5 /hm.%/ Total /hm.%/ Atoms converted Ca 3.195 1 55.944 43.244 99.188 P 1.922 0 8.000 - Ca 3.219 2 56.279 42.933 99.212 P 1.912 0 8.000 Ca 3.290 3 56.106 41.20a 97.314 P 1.884 0 8.000 Ca 3.234 4 56.430 42.710 99.140 P 1.906 0 8.000 Ca 3.226 5 57.117 42.786 99.903 P 1.906 0 8 * 000 Ca 3.199 6 57.299 43.538 100.837 P 1.921 0 8.000
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS83114A CS232230B1 (en) | 1983-01-07 | 1983-01-07 | Ceramic mass based on hydroxilapatite and oxihyldroxilapatite for implants and natural fixation |
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| Application Number | Priority Date | Filing Date | Title |
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| CS83114A CS232230B1 (en) | 1983-01-07 | 1983-01-07 | Ceramic mass based on hydroxilapatite and oxihyldroxilapatite for implants and natural fixation |
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| Publication Number | Publication Date |
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| CS11483A1 CS11483A1 (en) | 1984-05-14 |
| CS232230B1 true CS232230B1 (en) | 1985-01-16 |
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| CS83114A CS232230B1 (en) | 1983-01-07 | 1983-01-07 | Ceramic mass based on hydroxilapatite and oxihyldroxilapatite for implants and natural fixation |
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| CS11483A1 (en) | 1984-05-14 |
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