CS218337B1 - Prostaglandin F2 and Influenza or its analogue as gilts and sows induction agents - Google Patents

Abstract

The invention relates to the use of the prostaglandin 9a,11a,15o*-trihydroxy-5-cis-13-trans-prostadioic acid or its analogue 16-(3- -chlorophenoxy)-9a,11a«,15a-trihydroxy-17,18,- 19,20-tetranor-5-cis-13-trans-prostadioic acid for the induction of oestrus in gilts and sows.

Description

The present invention relates to the use of prostaglandin Fa aifa (9α, 11α, 15β-trihydroxy-5-cis-13-trans-propanedioic acid) or analogs thereof for the induction and elimination of resp. synchronization of gilts of gilts and sows.

Prostaglandin F2 _{and α,} or analogs thereof, are used in large-scale agricultural production for induction and / or production. synchronization of cattle heat or induction of sow birth. In addition, prostaglandin F2 _{and fa has} also found a number of uses in human therapy. The use of prostaglandin Fa _aUa or its analogues for the induction of gilts of gilts and sows was unknown.

Dithiocarbamoylhydrazines derivatives are used in combination with gonadotropic hormones for this purpose. A disadvantage of these methods used to induce gilts of gilts and sows is the variable syncogenic effect of the heat, as well as the low percentage of gilts sows and sows after insemination performed in the synchronized heat. The use of dithiocarbamoylhydrazine derivatives entails the disadvantages that the preparation has to be applied orally over a period of up to three weeks and the heat-synchronizing effect of the heat is extended over a longer period of time up to ten days. Furthermore, a teratogenic effect has been reported with dithiocarbamoylhydrazines derivatives.

In summary, it is not known at present that a preparation which, when administered, would cause the gilts and sows to be synchronized in more than 70% of the treated animals followed by a high percentage of gestation after the first insemination.

The disadvantages of the above method, using dithiocarbamoylhydrazine derivatives in combination with gonadotropic hormones to heat the heat of gilts and sows in combination with gonadotropic hormones, obviate the present invention. According to the invention, prostaglandin Fa _alpha or its analogues are used in repeated doses of 0.1 to 25 mg for the induction of heat in gilts and sows by dividing this amount into 3 to 5 doses which are applied over a period of 50 to 100 hours sequentially preferably at a time interval of 65 to 70 hours.

The use of prostaglandin F2 _and if _and / or its analogs according to the invention achieves up to 80% of the heat of the oestrus followed by 60 to 70% of the mating of the inseminated gilts and sows.

Application example

1. The group 8 sows which weaned did not during two months estrus was applied analogue of prostaglandin _{F2 Ia} bearing Oestrophan cloprostenol active substance [which is 16- (3-chlorophenoxy) -9a, LL ", 15 -trihydroxy-17,18,19,20-tetranor-5-cis-13-trans-prostadienoic acid] in the following doses:

On day 1, a dose of 250 µg cloprostenol im.

On day 2, 2 doses of 375 micrograms of cloprostenol im were administered at 8 hour interval a

On day 3, 2 doses of 500 micrograms of cloprostenol im were administered at 8 hour intervals.

In the 7 treated animals (87.5%), they were present within 3 days of heat in which insemination was performed. Of the inseminated sows, pregnancy was found in 5 animals (71.4%).

2. A group of 10 gilts anesthetized at 9 months of age were given Lutalyse / dinoprost, a salt of tris (hydroxymethyl) methylamine with 9α, 11α, 15α-trihydroxy-5-cis-13-trans-prostadienoic acid), according to the following scheme:

On day 1, a dose of 12.5 mg of dinoprost was administered.

On day 2, 2 doses were administered for 18.75 mg of dinoprost im at 8 hour interval a

On day 3, 2 doses of 25 milligrams of dinoprost im were administered. at 8-hour intervals.

In 7 treated animals (70%), they were present within 4 days of heat in which insemination was performed. Of the inseminated sows, pregnancy was found in 6 animals (85.7%).

Claims (1)

Use of prostaglandin 9α, 11α, 15α-trihydroxy-5-cis-13-trans-prostadienoic acid or its analogue 16- (3-chlorophenoxy) -9 ", 11", 15 "-trihydroxy-17,18,19,20- tetranor-5-cis-13-trans-prostadienoic acid for the induction of heat in gilts and sows.