CS195040B1 - Method of preparing fluid form of n-palmitoyl-ethanolamine - Google Patents
Method of preparing fluid form of n-palmitoyl-ethanolamine Download PDFInfo
- Publication number
- CS195040B1 CS195040B1 CS244877A CS244877A CS195040B1 CS 195040 B1 CS195040 B1 CS 195040B1 CS 244877 A CS244877 A CS 244877A CS 244877 A CS244877 A CS 244877A CS 195040 B1 CS195040 B1 CS 195040B1
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- palmitoyl
- ethanolamine
- fluid form
- liquid
- preparing fluid
- Prior art date
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- HXYVTAGFYLMHSO-UHFFFAOYSA-N palmitoyl ethanolamide Chemical compound CCCCCCCCCCCCCCCC(=O)NCCO HXYVTAGFYLMHSO-UHFFFAOYSA-N 0.000 title claims description 16
- 238000000034 method Methods 0.000 title claims description 7
- 239000012530 fluid Substances 0.000 title 1
- 239000007788 liquid Substances 0.000 claims description 10
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 6
- 229920000053 polysorbate 80 Polymers 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 5
- 239000000725 suspension Substances 0.000 claims description 5
- 239000003599 detergent Substances 0.000 claims description 4
- 239000003995 emulsifying agent Substances 0.000 claims description 4
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 4
- 229920000609 methyl cellulose Polymers 0.000 claims description 3
- 239000001923 methylcellulose Substances 0.000 claims description 3
- 239000000126 substance Substances 0.000 description 5
- 239000000203 mixture Substances 0.000 description 4
- 238000001816 cooling Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 238000002604 ultrasonography Methods 0.000 description 3
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000787 lecithin Substances 0.000 description 2
- 235000010445 lecithin Nutrition 0.000 description 2
- 229940067606 lecithin Drugs 0.000 description 2
- 241000220479 Acacia Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N EtOH Substances CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 235000010643 Leucaena leucocephala Nutrition 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 230000003044 adaptive effect Effects 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000013021 overheating Methods 0.000 description 1
- -1 polyethylene Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229940068968 polysorbate 80 Drugs 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000009210 therapy by ultrasound Methods 0.000 description 1
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- Medicinal Preparation (AREA)
- General Preparation And Processing Of Foods (AREA)
- Cosmetics (AREA)
Description
Vynález se týká způsobu přípravy tekuté formy N-palmitoyl-ethanolaminu.The present invention relates to a process for the preparation of a liquid form of N-palmitoyl-ethanolamine.
N-palmitoyl-ethanolamin /Impulsin Spofa/ je uváděn do terapie jako prostředek ke zvýšení adaptační ochrany lidského organismu proti onfekcím, jmenovitě k prevenci onemocnění horních cest dýchacích a chorob z nachlazení, které v zimním období značně narušují plynulost výrobních a organizačních procesů národního hospodářství.N-palmitoyl-ethanolamine (Impulsin Spofa) is being introduced into therapy as a means of enhancing the adaptive protection of the human body against onfections, namely the prevention of upper respiratory and cold illnesses, which significantly disturb the flow of production and organizational processes of the national economy.
N-palmitoyl-ethanolamin /Impulsin Spofa/ je krystalická látka o teplotě tání 98 až 99 °C, prakticky nerozpustná ve vodě, a dosavadní podávání ve formě tablet Činí resorpoi organismem problematickou. Tuto nevýhodu odstraňuje způaob přípravy tekuté formy léčiva N-palmitoyl-ethanolaminu /Impulsin Spofa/, jehož podstatou je, Že suspenzi N-palmitoyl-ethanolaminu ve vodě, která obsahuje emulgator anebo detergens, působí ultrazvukem. Jako emulgátor anebo 'detergens se použije lékopisně přípustná látka, s výhodou methylceluloza, polyoxyethylen sorbitan monooleat /Polysorbate 80,Tween 80/, lecithin nebo arabská guma. Disperzní proces lze urychlit, působí-li se ultrazvukem za teplot vyšších než 20 °C, s výhodou 60 až 98 °C. Tepelným účinkem ultrazvuku dochází k zahřátí celého systému a místnímu přehřátí, které způsobí ztekucení substance a tím i k dispergaci v systému kapalina/kapalina. Cílem působení ultrazvuku je získání mlékovité emulze. Nutný výkon ultrazvuku k disperzi závisí na množství zpracované látky. Pro laboratorní přípravu 100 ml 10 % tekuté ‘ormy léčiva postačí 2 až 5 min. působeníN-palmitoyl-ethanolamine (Impulsin Spofa) is a crystalline substance having a melting point of 98-99 ° C, practically insoluble in water, and the administration of tablets to date renders the organism problematic. This disadvantage is overcome by the preparation of the liquid form of the drug N-palmitoyl-ethanolamine (Impulsin Spofa), which is based on the fact that a suspension of N-palmitoyl-ethanolamine in water containing an emulsifier and / or detergent acts by ultrasound. An emulsifier or detergent is a pharmacologically acceptable substance, preferably methylcellulose, polyoxyethylene sorbitan monooleate (Polysorbate 80, Tween 80), lecithin or acacia. The dispersion process can be accelerated if ultrasonic treatment is carried out at temperatures above 20 ° C, preferably 60 to 98 ° C. The thermal effect of ultrasound heats the entire system and local overheating, which causes the substance to flow and thus disperses in the liquid / liquid system. The ultrasound effect is to obtain a milk-like emulsion. The necessary ultrasonic power to the dispersion depends on the amount of substance treated. For laboratory preparation of 100 ml of 10% liquid drug form, 2 to 5 minutes is sufficient. action
195 040 kmitočtem 20 kHz při výkonu 80 až 100 W.195 040 at 20 kHz at 80 to 100 W.
Získaný výrobek se a výhodou uchovává a distribuuje v polyethylenových nádobkách.The product obtained is preferably stored and distributed in polyethylene containers.
Jednotlivé dávka tekuté formy léčiva, připravená popsaným způsobem, je jedna Čajová lžička, představující 0,5 g substance. Chul přípravku lze upravit zředěním v běžných nápojích nebo přidáváním korigenoií již při výrobě.A single dose of the liquid form of the medicament prepared as described is one teaspoon representing 0.5 g of substance. The flavor of the preparation can be adjusted by diluting it with ordinary drinks or adding corrigenoids at the factory.
Postup podle vynálezu je ilustrován následujícími příklady provedení.The process according to the invention is illustrated by the following examples.
Příklad 1Example 1
Směs 10 g N-palmitoyl-ethanol.aminu /Impulsin Spofa/ a 90 ml 0,5 % methycelulozy ve vodě se zahřeje na 60 °C a na směs se působí ultrazvukem /20 kHz, 60 až 80 W/ po dobu 3 min. Doplněním objemu po vychlazení vodou na 100 ml se získá 100 ml 1Q% suspenze ve <ormě mlékovité kapaliny.A mixture of 10 g of N-palmitoyl-ethanol.amine (Impulsin Spofa) and 90 ml of 0.5% methylcellulose in water is heated to 60 ° C and the mixture is sonicated (20 kHz, 60-80 W) for 3 min. Making up the volume after cooling to 100 ml with water gives 100 ml of a 10% suspension in the milk-like liquid.
Příklad 2Example 2
Směs 10 g N-palmitoyl-ethanolaminu /Impulsin Spofa/ a 80 ml 1% vodného roztoku polyoxyethylen sorbitan monooleatu /Tween 80/ se zahřeje na 50 °C a na směs se působí ultrazvukem /20 kHz, 60 až 80 W/ podobu 4 minut. Doplněním objemu povychlazení vodou na 100 ml se získá 100 ml 10% suspenze ve formě mlékovité kapaliny.A mixture of 10 g of N-palmitoyl-ethanolamine (Impulsin Spofa) and 80 ml of a 1% aqueous solution of polyoxyethylene sorbitan monooleate (Tween 80) was heated to 50 ° C and sonicated (20 kHz, 60-80 W) for 4 minutes. . By adding 100 ml of the water-cooling rate, 100 ml of a 10% suspension is obtained as a milky liquid.
Příklad 3Example 3
Směs 10 g N-palmitoyl-ethanolaminu /Impulsin Spofa/ a 1 g lecithinu se přelije 90 ml vody, zahřeje se na 60 °C a na směs se působí ultrazvukem /20 kHz, 60 až 80 W/ po dobu 4 min. Po vychladnutí se objem doplní na 100 ml. Získá se 100 ml 10% suspenze ve formě mlékovité kapalihy.A mixture of 10 g of N-palmitoyl-ethanolamine (Impulsin Spofa) and 1 g of lecithin is poured over 90 ml of water, heated to 60 ° C and sonicated (20 kHz, 60-80 W) for 4 min. After cooling, make up the volume to 100 ml. 100 ml of a 10% suspension are obtained in the form of a milky liquid.
Claims (2)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS244877A CS195040B1 (en) | 1977-04-14 | 1977-04-14 | Method of preparing fluid form of n-palmitoyl-ethanolamine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS244877A CS195040B1 (en) | 1977-04-14 | 1977-04-14 | Method of preparing fluid form of n-palmitoyl-ethanolamine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CS195040B1 true CS195040B1 (en) | 1980-01-31 |
Family
ID=5361653
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS244877A CS195040B1 (en) | 1977-04-14 | 1977-04-14 | Method of preparing fluid form of n-palmitoyl-ethanolamine |
Country Status (1)
| Country | Link |
|---|---|
| CS (1) | CS195040B1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7199082B1 (en) * | 1999-10-28 | 2007-04-03 | University Of North Texas | Methods for extending the freshness of cut flowers, ornamental trees, and plant cuttings |
-
1977
- 1977-04-14 CS CS244877A patent/CS195040B1/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7199082B1 (en) * | 1999-10-28 | 2007-04-03 | University Of North Texas | Methods for extending the freshness of cut flowers, ornamental trees, and plant cuttings |
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