CS181207B2 - Method of producing benzocycloheptaisochinoline derivatives - Google Patents

Method of producing benzocycloheptaisochinoline derivatives

Info

Publication number
CS181207B2
CS181207B2 CS7100000935A CS93571A CS181207B2 CS 181207 B2 CS181207 B2 CS 181207B2 CS 7100000935 A CS7100000935 A CS 7100000935A CS 93571 A CS93571 A CS 93571A CS 181207 B2 CS181207 B2 CS 181207B2
Authority
CS
Czechoslovakia
Prior art keywords
benzocycloheptaisochinoline
derivatives
producing
producing benzocycloheptaisochinoline
benzocycloheptaisochinoline derivatives
Prior art date
Application number
CS7100000935A
Other languages
Czech (cs)
English (en)
Inventor
Francois T Bruderlein
Leslie G Humber
Original Assignee
Francois T Bruderlein
Leslie G Humber
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Francois T Bruderlein, Leslie G Humber filed Critical Francois T Bruderlein
Priority claimed from US510275A external-priority patent/US3922346A/en
Publication of CS181207B2 publication Critical patent/CS181207B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C07D211/76—Oxygen atoms attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CS7100000935A 1970-02-10 1971-02-09 Method of producing benzocycloheptaisochinoline derivatives CS181207B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1030670A 1970-02-10 1970-02-10
US097481A US3914305A (en) 1970-02-10 1970-12-21 N-{8 (10,11-dihydro-5H-dibenzo{8 a,d{9 cyclohepten-5-yl)methyl{9 amides
US510275A US3922346A (en) 1970-02-10 1974-09-30 Benzocycloheptaisoquinoline derivatives III in producing CNS depressant effects

Publications (1)

Publication Number Publication Date
CS181207B2 true CS181207B2 (en) 1978-03-31

Family

ID=27359200

Family Applications (1)

Application Number Title Priority Date Filing Date
CS7100000935A CS181207B2 (en) 1970-02-10 1971-02-09 Method of producing benzocycloheptaisochinoline derivatives

Country Status (14)

Country Link
US (2) US3657250A (xx)
AR (4) AR195768A1 (xx)
BE (1) BE762595A (xx)
CA (1) CA982124A (xx)
CH (3) CH569716A5 (xx)
CS (1) CS181207B2 (xx)
DE (1) DE2106165A1 (xx)
DK (1) DK139582B (xx)
FI (1) FI49504C (xx)
FR (1) FR2081498B1 (xx)
GB (1) GB1341109A (xx)
NL (1) NL170733C (xx)
SE (2) SE401674B (xx)
ZA (1) ZA71532B (xx)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3896130A (en) * 1972-08-04 1975-07-22 Ayerst Mckenna & Harrison Ocathydrobenzocycloheptapyridoisoquinoline derivatives and process for the preparation thereof
US4062851A (en) * 1975-11-26 1977-12-13 Ayerst Mckenna And Harrison Ltd. Process for the resolution of certain octahydrobenzocycloheptapyridoisoquinolinols
US4053604A (en) * 1975-11-26 1977-10-11 Ayerst, Mckenna & Harrison Limited Method for improving anesthesia and compositions therefor
US4059585A (en) * 1976-07-27 1977-11-22 Ayerst Mckenna And Harrison Ltd. Process for preparing an intermediate for CNS depressants
FR2366839A2 (fr) * 1976-10-08 1978-05-05 Ayerst Mckenna & Harrison Derives de benzocycloheptane-isoquinoleine
TWI375676B (en) * 2005-08-29 2012-11-01 Msd Oss Bv Non-steroidal glucocorticoid receptor modulators
CA3007641C (en) 2015-12-09 2023-10-17 Brandeis University Dbh inhibitors for treating or preventing memory loss
CN109970626A (zh) * 2018-12-30 2019-07-05 南京正荣医药化学有限公司 一种2-哌啶酮碱金属盐的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US336175A (en) * 1886-02-16 tompeins
US3052721A (en) * 1961-01-10 1962-09-04 Olin Mathieson Dihydrodibenzocy cloheptene derivatives
US3403157A (en) * 1965-09-01 1968-09-24 American Home Prod Benzo[6, 7]cyclohepta[1, 2, 3-d, e]isoquinoline derivatives

Also Published As

Publication number Publication date
GB1341109A (en) 1973-12-19
NL7101752A (xx) 1971-08-12
US3914305A (en) 1975-10-21
AR195768A1 (es) 1973-11-09
SE401674B (sv) 1978-05-22
DK139582C (xx) 1979-09-03
SE406195B (sv) 1979-01-29
AR195786A1 (es) 1973-11-09
CH584201A5 (xx) 1977-01-31
BE762595A (fr) 1971-08-05
DE2106165A1 (de) 1971-08-19
AR195785A1 (es) 1973-11-09
ZA71532B (en) 1972-07-26
NL170733C (nl) 1982-12-16
FR2081498A1 (xx) 1971-12-03
CH569716A5 (xx) 1975-11-28
NL170733B (nl) 1982-07-16
FR2081498B1 (xx) 1975-01-17
FI49504C (fi) 1975-07-10
FI49504B (xx) 1975-04-01
CH548395A (fr) 1974-04-30
DK139582B (da) 1979-03-12
AR206589A1 (es) 1976-08-06
CA982124A (en) 1976-01-20
US3657250A (en) 1972-04-18

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