CR9962A - ENZYMATIC INHIBITION COMPOUNDS - Google Patents

ENZYMATIC INHIBITION COMPOUNDS

Info

Publication number
CR9962A
CR9962A CR9962A CR9962A CR9962A CR 9962 A CR9962 A CR 9962A CR 9962 A CR9962 A CR 9962A CR 9962 A CR9962 A CR 9962A CR 9962 A CR9962 A CR 9962A
Authority
CR
Costa Rica
Prior art keywords
peptide
based compounds
enzymatic inhibition
inhibition compounds
ntn
Prior art date
Application number
CR9962A
Other languages
Spanish (es)
Inventor
Zhou Han-Jie
M. Sun Congcong
D. Shenk Kevin
J. Laidig Guy
Original Assignee
Proteolix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Proteolix Inc filed Critical Proteolix Inc
Publication of CR9962A publication Critical patent/CR9962A/en

Links

Abstract

Compuestos basados en peptidos, incluyendo anillos de tres miembros que contienen heteroatomos, inhiben eficiente y selectivamente las actividades especificas de las hidrolasas de nucleofilos N-terminales (Ntn) asociadas al proteosoma. Los compuestos basados en peptidos incluyen un epoxido o aziridina y funcionalizacion en el extremo N. Entre otras utilidades terapeuticas, se espera que los compuestos basados en peptidos exhiban propiedades antiflamatorias e inhibicion de la proliferacion celular.Peptide-based compounds, including three-membered rings containing heteroatoms, efficiently and selectively inhibit the specific activities of N-terminal nucleophilic hydrolases (Ntn) associated with the proteasome. Peptide-based compounds include an epoxide or aziridine and functionalization at the N-terminus. Among other therapeutic utilities, peptide-based compounds are expected to exhibit anti-inflammatory properties and inhibition of cell proliferation.

CR9962A 2005-09-05 2008-05-08 ENZYMATIC INHIBITION COMPOUNDS CR9962A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US84258205P 2005-09-05 2005-09-05
US37611805P 2005-11-09 2005-11-09
CR20130545A CR20130545A (en) 2005-09-05 2013-10-24 COMPOUNDS FOR ENZYMATIC INHIBITION (PATENT DIVISIONAL 9962)

Publications (1)

Publication Number Publication Date
CR9962A true CR9962A (en) 2008-10-17

Family

ID=44839428

Family Applications (2)

Application Number Title Priority Date Filing Date
CR9962A CR9962A (en) 2005-09-05 2008-05-08 ENZYMATIC INHIBITION COMPOUNDS
CR20130545A CR20130545A (en) 2005-09-05 2013-10-24 COMPOUNDS FOR ENZYMATIC INHIBITION (PATENT DIVISIONAL 9962)

Family Applications After (1)

Application Number Title Priority Date Filing Date
CR20130545A CR20130545A (en) 2005-09-05 2013-10-24 COMPOUNDS FOR ENZYMATIC INHIBITION (PATENT DIVISIONAL 9962)

Country Status (1)

Country Link
CR (2) CR9962A (en)

Also Published As

Publication number Publication date
CR20130545A (en) 2013-11-29

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