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Application filed by Neurogen Corp, PfizerfiledCriticalNeurogen Corp
Priority to CR6999ApriorityCriticalpatent/CR6999A/en
Publication of CR6999ApublicationCriticalpatent/CR6999A/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Plural Heterocyclic Compounds
(AREA)
Abstract
La invencion esta particularmente relacionada con los compuestos que se adhieren con alta selectividad y alta afinidad al sitio benzodiazepina de los receptores GABAa. Esta invencion se refiere tambien a las composiciones farmaceuticas que comprenden dichos compuestos y al uso de dichos compuestos para el tratamiento de ciertas enfermedades del sistema nervioso central (CNS). Se describen nuevos procedimientos para preparar los compuestos de la Formula I. Se refiere tambien al uso de bencimidazoles, piridilimidazoles y compuestos heteroarilo biciclicos relacionados de la Formula I en combinacion con uno o mas de otros agentes del CNS para potenciar los efectos de los otros agentes CNS.The invention is particularly related to compounds that adhere with high selectivity and high affinity to the benzodiazepine site of GABAa receptors. This invention also relates to pharmaceutical compositions comprising said compounds and the use of said compounds for the treatment of certain diseases of the central nervous system (CNS). New methods are described for preparing the compounds of Formula I. It also refers to the use of benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds of Formula I in combination with one or more other CNS agents to enhance the effects of the other agents. CNS
CR6999A2003-06-172003-06-17
BENZIMIDAZOL AND PIRIDILIMIDAZOL DERIVATIVES AS LIGANDOS FOR GABAa
CR6999A
(en)
Compounds derived from [heteroaryl aryl] - [substituted 1-piperidinyl] methanone, ccr-2, ccr-3, ccr-5 receptor antagonist; Preparation process; pharmaceutical composition comprising them; and its use in the treatment of peripheral arterial occlusive disease and critical ischemia of the extremities, among others.
DERIVATIVES OF 2,3-DIHYDROBENZO [1,4] DIOXIN-2-ILMETILO AS ALFA2C ANTAGONISTS FOR USE IN THE TREATMENT OF CENTRAL AND PERIPHERAL NERVOUS SYSTEM DISEASES