CR20230287A - Compounds for the treatment of kinase-dependent disorders - Google Patents

Compounds for the treatment of kinase-dependent disorders

Info

Publication number
CR20230287A
CR20230287A CR20230287A CR20230287A CR20230287A CR 20230287 A CR20230287 A CR 20230287A CR 20230287 A CR20230287 A CR 20230287A CR 20230287 A CR20230287 A CR 20230287A CR 20230287 A CR20230287 A CR 20230287A
Authority
CR
Costa Rica
Prior art keywords
compounds
kinase
treatment
dependent disorders
compositions
Prior art date
Application number
CR20230287A
Other languages
Spanish (es)
Inventor
Kin Tso
Lynne Canne Bannen
Minna Bui
Wei Xu
Faming Jiang
Yong Wang
Original Assignee
Exelixis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exelixis Inc filed Critical Exelixis Inc
Publication of CR20230287A publication Critical patent/CR20230287A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/60—Quinoline or hydrogenated quinoline ring systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Disclosed herein are compounds of formula I. Compounds of formula I inhibit, regulate and/or modulate kinase receptor, particularly Axl and Mer signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.
CR20230287A 2018-01-26 2019-01-25 Compounds for the treatment of kinase-dependent disorders CR20230287A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862622702P 2018-01-26 2018-01-26
US201862758321P 2018-11-09 2018-11-09
PCT/US2019/015297 WO2019148044A1 (en) 2018-01-26 2019-01-25 Compounds for the treatment of kinase-dependent disorders

Publications (1)

Publication Number Publication Date
CR20230287A true CR20230287A (en) 2023-07-26

Family

ID=65409544

Family Applications (2)

Application Number Title Priority Date Filing Date
CR20200358A CR20200358A (en) 2018-01-26 2019-01-25 Compounds for the treatment of kinase-dependent disorders
CR20230287A CR20230287A (en) 2018-01-26 2019-01-25 Compounds for the treatment of kinase-dependent disorders

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CR20200358A CR20200358A (en) 2018-01-26 2019-01-25 Compounds for the treatment of kinase-dependent disorders

Country Status (19)

Country Link
US (2) US11542259B2 (en)
EP (1) EP3743070A1 (en)
JP (2) JP7321165B2 (en)
CN (5) CN117624045A (en)
AU (2) AU2019212801B2 (en)
BR (1) BR112020015201A2 (en)
CA (1) CA3088200A1 (en)
CL (1) CL2020001931A1 (en)
CO (1) CO2020010465A2 (en)
CR (2) CR20200358A (en)
IL (2) IL300824A (en)
MA (1) MA51673A (en)
MX (2) MX2020007765A (en)
PE (1) PE20211203A1 (en)
PH (1) PH12020551208A1 (en)
SA (1) SA520412500B1 (en)
SG (1) SG11202006921PA (en)
UA (1) UA128476C2 (en)
WO (1) WO2019148044A1 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL300824A (en) * 2018-01-26 2023-04-01 Exelixis Inc Compounds for the treatment of kinase-dependent disorders
US11673897B2 (en) 2018-01-26 2023-06-13 Exelixis, Inc. Compounds for the treatment of kinase-dependent disorders
US11866431B2 (en) 2018-11-09 2024-01-09 Vivace Therapeutics, Inc. Bicyclic compounds
PE20211757A1 (en) * 2018-12-13 2021-09-07 Exelixis Inc CRYSTALLINE FORMS AND SALT FORMS OF A KINASE INHIBITOR
CN113710322A (en) * 2019-01-25 2021-11-26 埃克塞里艾克西斯公司 Compounds for the treatment of kinase-dependent disorders
CN109761899B (en) * 2019-02-14 2022-11-15 广州六顺生物科技股份有限公司 Quinoline derivative, pharmaceutically acceptable salt or solvate thereof, application thereof, medicine and pharmaceutical composition
TWI849107B (en) 2019-04-16 2024-07-21 美商維瓦斯治療公司 Bicyclic compounds
AU2019449809A1 (en) * 2019-06-03 2021-12-16 Exelixis, Inc. Crystalline salt forms of a kinase inhibitor
CN110845406B (en) * 2019-12-04 2021-07-20 广州安岩仁医药科技有限公司 Preparation method of quinoline compound
US20230150956A1 (en) * 2020-02-10 2023-05-18 Stemsynergy Therapeutics, Inc. Myc inhibitors and uses thereof
US20230192619A1 (en) * 2020-04-30 2023-06-22 Exelixis, Inc. Processes for the Preparation of a Kinase Inhibitor
JP2023536264A (en) * 2020-07-31 2023-08-24 エグゼリクシス， インコーポレイテッド Combinations for the treatment of cancer
PE20240223A1 (en) 2020-11-05 2024-02-16 Exelixis Inc PHARMACEUTICAL COMPOSITIONS OF A KINASE INHIBITOR
WO2022161447A1 (en) * 2021-02-01 2022-08-04 江苏恒瑞医药股份有限公司 Dicarboxamide compound, preparation method therefor, and pharmaceutical use thereof
CN113582924A (en) * 2021-09-09 2021-11-02 四川国康药业有限公司 Multi-target tyrosine kinase inhibitor and preparation method and application thereof
AR127561A1 (en) * 2021-11-03 2024-02-07 Exelixis Inc COMPOUNDS FOR THE TREATMENT OF KINASE DEPENDENT DISORDERS
WO2023122739A1 (en) 2021-12-22 2023-06-29 Exelixis, Inc. Crystalline forms and salt forms of a kinase inhibitor
CN114573553B (en) * 2022-01-27 2023-11-10 广州六顺生物科技有限公司 Heteroaromatic ring derivative and preparation method and application thereof

Family Cites Families (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5804396A (en) 1994-10-12 1998-09-08 Sugen, Inc. Assay for agents active in proliferative disorders
EP3103799B1 (en) 1995-03-30 2018-06-06 OSI Pharmaceuticals, LLC Quinazoline derivatives
GB9508565D0 (en) 1995-04-27 1995-06-14 Zeneca Ltd Quiazoline derivative
GB9508538D0 (en) 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
IL126351A0 (en) 1996-04-12 1999-05-09 Warner Lambert Co Irreversible inhibitors of tyrosine kinases
UA73073C2 (en) 1997-04-03 2005-06-15 Уайт Холдінгз Корпорейшн Substituted 3-cyan chinolines
ZA986732B (en) 1997-07-29 1999-02-02 Warner Lambert Co Irreversible inhibitiors of tyrosine kinases
ZA986729B (en) 1997-07-29 1999-02-02 Warner Lambert Co Irreversible inhibitors of tyrosine kinases
TW436485B (en) 1997-08-01 2001-05-28 American Cyanamid Co Substituted quinazoline derivatives
KR100600550B1 (en) * 2000-10-20 2006-07-13 에자이 가부시키가이샤 Nitrogenous aromatic ring compounds
EP2612853A1 (en) 2003-09-26 2013-07-10 Exelixis Inc. c-Met modulators and methods of use
US7314622B2 (en) 2005-04-15 2008-01-01 Neogenix Oncology, Inc. Recombinant monoclonal antibodies and corresponding antigens for colon and pancreatic cancers
NZ563193A (en) 2005-05-09 2010-05-28 Ono Pharmaceutical Co Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics
JPWO2007052849A1 (en) * 2005-11-07 2009-04-30 エーザイ・アール・アンド・ディー・マネジメント株式会社 Combination use of angiogenesis inhibitor and c-kit kinase inhibitor
MX2011004018A (en) * 2008-10-14 2011-06-24 Ning Xi Compounds and methods of use.
TWI447108B (en) 2009-01-16 2014-08-01 Exelixis Inc Malate salts of n-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, and crystalline forms thereof
EP2213686A1 (en) 2009-01-28 2010-08-04 Externautics S.p.A. Tumor markers and methods of use thereof
EP2214019A1 (en) 2009-01-28 2010-08-04 Externautics S.p.A. Tumor markers and methods of use thereof
UA108618C2 (en) 2009-08-07 2015-05-25 APPLICATION OF C-MET-MODULATORS IN COMBINATION WITH THEMOSOLOMID AND / OR RADIATION THERAPY FOR CANCER TREATMENT
WO2011051280A1 (en) 2009-10-26 2011-05-05 Externautics S.P.A. Ovary tumor markers and methods of use thereof
WO2011051277A1 (en) 2009-10-26 2011-05-05 Externautics S.P.A. Breast tumor markers and methods of use thereof
EP2494362B1 (en) 2009-10-26 2016-06-08 Externautics S.p.A. Prostate tumor markers and methods of use thereof
WO2011051276A1 (en) 2009-10-26 2011-05-05 Externautics S.P.A. Colon and rectal tumor markers and methods of use thereof
US20120322075A1 (en) 2009-10-26 2012-12-20 Externautics S.P.A. Lung Tumor Markers and Methods of Use Thereof
US20120070368A1 (en) * 2010-04-16 2012-03-22 Exelixis, Inc. Methods of Using C-Met Modulators
EP2383578A1 (en) 2010-04-30 2011-11-02 Externautics S.p.A. Tumor marker and methods of use thereof
AU2011278832B2 (en) * 2010-07-14 2014-03-13 Betta Pharmaceuticals Co., Ltd Novel fused heterocyclic derivatives useful as c-Met tyrosine kinase inhibitors
PL2593090T3 (en) 2010-07-16 2022-02-21 Exelixis, Inc. C-met modulator pharmaceutical compositions
US8664244B2 (en) * 2010-09-12 2014-03-04 Advenchen Pharmaceuticals, LLC Compounds as c-Met kinase inhibitors
ES2754973T5 (en) 2010-09-27 2023-03-13 Exelixis Inc Dual MET and VEGF inhibitors for the treatment of castration-resistant prostate cancer and osteoblastic bone metastases
CN102093421B (en) * 2011-01-28 2014-07-02 北京康辰药业有限公司 Phosphorus substituent group-containing quinoline compound and preparation method of quinoline compound as well as pharmaceutical composition containing quinoline compound and application of pharmaceutical composition
KR20210147117A (en) 2011-02-10 2021-12-06 엑셀리시스, 인코포레이티드 Processes for preparing quinoline compounds and pharmaceutical compositions containing such compounds
US20120252840A1 (en) 2011-04-04 2012-10-04 Exelixis, Inc. Method of Treating Cancer
GEP201706678B (en) 2011-05-02 2017-06-12 Exelixis Inc Method of treating cancer and bone cancer
CN102408411B (en) * 2011-09-19 2014-10-22 北京康辰药业股份有限公司 Hydroximic acid compound containing quinolyl and preparation method thereof, and drug composition containing the compound and use thereof
EP2758057B1 (en) 2011-09-22 2017-05-31 Exelixis, Inc. Method for treating osteoporosis
BR112014009302B1 (en) 2011-10-20 2020-04-28 Exelis Inc Us/Us process for preparing quinoline derivatives
AR088813A1 (en) 2011-11-08 2014-07-10 Exelixis Inc METHOD FOR QUANTIFYING CANCER TREATMENT
TW201818937A (en) 2011-11-08 2018-06-01 美商艾克塞里克斯公司 Method of treating cancer
US9861624B2 (en) 2012-05-02 2018-01-09 Exelixis, Inc. Method of treating cancer
CN114129566A (en) 2012-09-07 2022-03-04 埃克塞里艾克西斯公司 Inhibitors of MET, VEGFR and RET for the treatment of lung adenocarcinoma
CN104994873B (en) 2012-10-04 2017-12-22 达纳－法伯癌症研究所公司 The anti-PD L1 antibody of human monoclonal and application method
UA119321C2 (en) 2013-03-15 2019-06-10 Екселіксіс, Інк. Metabolites of n-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide
JP2016515628A (en) 2013-04-04 2016-05-30 エグゼリクシス， インコーポレイテッド Combined drugs to treat cancer
ES2927651T3 (en) 2013-04-04 2022-11-10 Exelixis Inc Cabozantinib dosage form and use in cancer treatment
SG11201508528TA (en) 2013-05-02 2015-11-27 Anaptysbio Inc Antibodies directed against programmed death-1 (pd-1)
US10359428B2 (en) 2013-06-14 2019-07-23 Externautics S.P.A. Tumor marker, monoclonal antibodies and methods of use thereof
BR112016010224A2 (en) 2013-11-05 2018-05-02 Cognate Bioservices, Inc. checkpoint inhibitor combinations and therapeutic products to treat cancer.
CA3181899A1 (en) 2014-02-14 2015-08-20 Exelixis, Inc. Crystalline solid forms of n-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-n'-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide, processes for making, and methods of use
JP6666849B2 (en) 2014-03-17 2020-03-18 エグゼリクシス， インコーポレイテッド Administration of cabozantinib preparation
PL3134084T3 (en) 2014-04-25 2021-09-27 Exelixis, Inc. Method of treating lung adenocarcinoma
WO2016019285A1 (en) 2014-07-31 2016-02-04 Exelixis, Inc. Method of preparing fluorine-18 labeled cabozantinib and its analogs
CA2957466C (en) 2014-08-05 2023-10-17 Exelixis, Inc. Drug combinations to treat multiple myeloma
CN104817497B (en) * 2015-03-20 2017-03-08 南京众睿缘生物科技有限公司 A kind of alkynes is for quinoline and its production and use
CN106279147A (en) 2015-05-21 2017-01-04 中国科学院上海药物研究所 A kind of pyrido nitrogen heterocyclic and its production and use
US20170342033A1 (en) * 2015-06-29 2017-11-30 Ontogenesis, Llc Multi-Tyrosine Kinase Inhibitors Derivatives and Methods of Use
US20180009758A1 (en) * 2015-06-29 2018-01-11 Ontogenesis, Llc Multi-Tyrosine Kinase Inhibitors Derivatives and Methods of Use
CA3020749A1 (en) 2016-04-15 2017-10-19 Exelixis, Inc. Method of treating renal cell carcinoma using n-(4-(6,7-dimethoxyquinolin-4-yloxy) phenyl)-n'-(4-fluoropheny)cyclopropane-1,1-dicarboxamide, (2s)-hydroxybutanedioate
US20210030737A1 (en) 2016-04-19 2021-02-04 Exelixis, Inc. Triple Negative Breast Cancer Treatment Method
CN105797123A (en) * 2016-05-18 2016-07-27 王超 Traditional Chinese medicinal composition for treating infertility
CN106400155A (en) * 2016-08-31 2017-02-15 飞佛特种纺织品（宁波）有限公司 Anti-aging sunshine fabric
CN107235896B (en) * 2016-09-13 2019-11-05 上海翔锦生物科技有限公司 Tyrosine kinase inhibitor and its application
CA3038500A1 (en) 2016-09-27 2018-04-05 Andrea B. Apolo Method of treating urothelial carcinoma and other genitourinary malignancies using n-(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
AU2018210397B2 (en) 2017-01-20 2024-02-29 Exelixis, Inc. Combinations of cabozantinib and atezolizumab to treat cancer
WO2018145621A1 (en) * 2017-02-07 2018-08-16 恩瑞生物医药科技（上海）有限公司 Quinoline compound, preparation method and medical use therefor
CA3060370A1 (en) 2017-05-26 2018-11-29 Exelixis, Inc. Crystalline solid forms of salts of n-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-n'-(4-fluorphenyl) cyclopropane-1,1-dicarboxamide, processes for making, and methods of use
WO2018227119A1 (en) 2017-06-09 2018-12-13 Exelixis, Inc. Liquid dosage forms to treat cancer
CA3086522A1 (en) * 2017-12-20 2019-06-27 Angex Pharmaceutical, Inc. Carbamate and urea compounds as multikinase inhibitors
US20190262330A1 (en) 2017-12-21 2019-08-29 Exelixis, Inc. Method of Treating Hepatocellular Carcinoma Using N-(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, (2S)-hydroxybutanedioate
US11673897B2 (en) * 2018-01-26 2023-06-13 Exelixis, Inc. Compounds for the treatment of kinase-dependent disorders
IL300824A (en) * 2018-01-26 2023-04-01 Exelixis Inc Compounds for the treatment of kinase-dependent disorders
MA51672A (en) * 2018-01-26 2020-12-02 Exelixis Inc COMPOUNDS INTENDED FOR THE TREATMENT OF KINASIS-DEPENDENT DISORDERS
PE20211757A1 (en) * 2018-12-13 2021-09-07 Exelixis Inc CRYSTALLINE FORMS AND SALT FORMS OF A KINASE INHIBITOR
CN113710322A (en) * 2019-01-25 2021-11-26 埃克塞里艾克西斯公司 Compounds for the treatment of kinase-dependent disorders
AU2019449809A1 (en) * 2019-06-03 2021-12-16 Exelixis, Inc. Crystalline salt forms of a kinase inhibitor
AR119069A1 (en) * 2019-06-04 2021-11-24 Exelixis Inc COMPOUNDS FOR THE TREATMENT OF KINASE-DEPENDENT DISORDERS
US20230192619A1 (en) * 2020-04-30 2023-06-22 Exelixis, Inc. Processes for the Preparation of a Kinase Inhibitor
JP2023536264A (en) * 2020-07-31 2023-08-24 エグゼリクシス， インコーポレイテッド Combinations for the treatment of cancer
PE20240223A1 (en) * 2020-11-05 2024-02-16 Exelixis Inc PHARMACEUTICAL COMPOSITIONS OF A KINASE INHIBITOR
AR127561A1 (en) * 2021-11-03 2024-02-07 Exelixis Inc COMPOUNDS FOR THE TREATMENT OF KINASE DEPENDENT DISORDERS
WO2023122739A1 (en) * 2021-12-22 2023-06-29 Exelixis, Inc. Crystalline forms and salt forms of a kinase inhibitor

Also Published As

Publication number Publication date
WO2019148044A1 (en) 2019-08-01
EP3743070A1 (en) 2020-12-02
IL276032A (en) 2020-08-31
JP2021511360A (en) 2021-05-06
CN111757735A (en) 2020-10-09
AU2024205373A1 (en) 2024-08-22
US11542259B2 (en) 2023-01-03
SG11202006921PA (en) 2020-08-28
CN117402114A (en) 2024-01-16
AU2019212801B2 (en) 2024-07-04
JP2023103446A (en) 2023-07-26
CN117820226A (en) 2024-04-05
PE20211203A1 (en) 2021-07-05
MA51673A (en) 2020-12-02
CN111757735B (en) 2023-09-22
CN117624045A (en) 2024-03-01
CN117603138A (en) 2024-02-27
JP7321165B2 (en) 2023-08-04
US20210040076A1 (en) 2021-02-11
CO2020010465A2 (en) 2020-10-30
US20240043414A1 (en) 2024-02-08
SA520412500B1 (en) 2024-06-23
AU2019212801A1 (en) 2020-08-20
UA128476C2 (en) 2024-07-24
PH12020551208A1 (en) 2021-05-17
KR20200115582A (en) 2020-10-07
CL2020001931A1 (en) 2020-12-11
BR112020015201A2 (en) 2020-12-29
MX2022016051A (en) 2023-02-01
IL300824A (en) 2023-04-01
MX2020007765A (en) 2020-09-25
CA3088200A1 (en) 2019-08-01
CR20200358A (en) 2021-02-22

Similar Documents

Publication Publication Date Title
PH12020551208A1 (en) Compounds for the treatment of kinase-dependent disorders
MX2022014351A (en) Compounds for the treatment of kinase-dependent disorders.
MX2021013110A (en) Heterocyclic compounds as ret kinase inhibitors.
PH12020550881A1 (en) Substituted bicyclic heterocyclic compounds as prmt5 inhibitors
MY202022A (en) Pyrrolotriazine compounds as tam inhibitors
EA201690391A1 (en) SELECTIVE MODULATORS OF SPHINGOZIN-1-PHOSPHATE RECEPTOR AND METHODS OF CHIRAL SYNTHESIS
EA201592033A1 (en) 3- (2-AMINOPYRIMIDIN-4-IL) -5- (3-HYDROXYPROPYNYL) -1H-PYRROLO [2,3-c] PyRIDINE DERIVATIVES AS NIK INHIBITORS FOR CANCER TREATMENT
WO2014194245A3 (en) Cdk8 inhibitors and uses thereof
SA519410320B1 (en) Phenyl-2-Hydroxy-Acetylamino-2-Methyl-Phenyl Compounds
EA201290329A1 (en) SELECTIVE HETERROCYCLIC MODULATORS OF SPHINGOZIN-1-PHOSPHATE RECEPTOR
EA033236B1 (en) New pyrazole derivatives as nik inhibitors
PH12020551170A1 (en) Triazolopyrimidine derivatives for use as ghrelin o-acyl transferase (goat) inhibitors
PH12020551390A1 (en) AMINOPYRAZINE DIOL COMPOUNDS AS PI3K-y INHIBITORS
EA201291055A1 (en) PROTEINTIROZINKINASE ACTIVITY INHIBITORS AND THEIR APPLICATION FOR THE TREATMENT OF EYE DISEASES
EA202090414A1 (en) COMPOUNDS AND THEIR APPLICATION
MY197064A (en) Oxadiazolopyridine derivatives for use as ghrelin o-acyl transferase (goat) inhibitors
MX2022003671A (en) Inhibitors of receptor interacting protein kinase i for the treatment of disease.
CA3139156A1 (en) Compounds for the treatment of kinase-dependent disorders
MX2023009059A (en) Gpr84 antagonists and uses thereof.
MX2022002443A (en) Perk inhibiting compounds.
EA202091790A1 (en) COMPOUNDS FOR TREATMENT OF KINASO-DEPENDENT DISORDERS
EA202091789A1 (en) COMPOUNDS FOR TREATMENT OF KINASO-DEPENDENT DISORDERS
EA202091424A1 (en) SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS
UA110978C2 (en) Azetidinylphenyl, pyridyl or pyrazinylcarboxamide derivatives as JAK inhibitors