CR20170229A - 1- [2- (AMINOMETIL) BENCIL] -2-THIOXO-1,2,3,5-TETRAHYDRO-4H-PIRROLO [3,2-D] PYRIMIDIN-4-ONAS AS MYELOPEROXIDASE INHIBITORS - Google Patents

1- [2- (AMINOMETIL) BENCIL] -2-THIOXO-1,2,3,5-TETRAHYDRO-4H-PIRROLO [3,2-D] PYRIMIDIN-4-ONAS AS MYELOPEROXIDASE INHIBITORS

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Publication number
CR20170229A
CR20170229A CR20170229A CR20170229A CR20170229A CR 20170229 A CR20170229 A CR 20170229A CR 20170229 A CR20170229 A CR 20170229A CR 20170229 A CR20170229 A CR 20170229A CR 20170229 A CR20170229 A CR 20170229A
Authority
CR
Costa Rica
Prior art keywords
thioxo
pyrimidin
tetrahydro
aminometil
bencil
Prior art date
Application number
CR20170229A
Other languages
Spanish (es)
Inventor
Nicholas Tomkinson
Ulrik Jurva
Tord Bertil Inghardt
Jefrey Paul Stonehouse
Erik Michaelsson
Petra Johannesson
Eva-Lotte Lindstedt-Alstermark
Li-Ming Gan
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Priority claimed from PCT/EP2015/077998 external-priority patent/WO2016087338A1/en
Publication of CR20170229A publication Critical patent/CR20170229A/en

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  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se dan a conocer determinados compuestos de 1-[2-(aminometil)bencil]-2-tioxo-1,2,3,5-tetrahidro-4H-pirrolo[3,2-d]pirimidin-4-ona de fórmula (I),y sales farmacéuticamente aceptable de los mismos, junto con composiciones que los contienen y su uso en terapia. Los compuestos son inhibidores de la enzima MPO y de este modo son particularmente útiles en el tratamiento o profilaxis de trastornos cardiovasculares tales como insuficiencia cardíaca y estados relacionados con arteriopatía coronaria. NHNNHOSR2NHR3R1(I)Certain 1- [2- (aminomethyl) benzyl] -2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo [3,2-d] pyrimidin-4-one compounds of formula ( I), and pharmaceutically acceptable salts thereof, together with compositions containing them and their use in therapy. The compounds are inhibitors of the MPO enzyme and thus are particularly useful in the treatment or prophylaxis of cardiovascular disorders such as heart failure and conditions related to coronary artery disease. NHNNHOSR2NHR3R1 (I)

CR20170229A 2014-12-01 2015-11-30 1- [2- (AMINOMETIL) BENCIL] -2-THIOXO-1,2,3,5-TETRAHYDRO-4H-PIRROLO [3,2-D] PYRIMIDIN-4-ONAS AS MYELOPEROXIDASE INHIBITORS CR20170229A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462085722P 2014-12-01 2014-12-01
PCT/EP2015/077998 WO2016087338A1 (en) 2014-12-01 2015-11-30 1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4h-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase

Publications (1)

Publication Number Publication Date
CR20170229A true CR20170229A (en) 2017-09-20

Family

ID=58672229

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20170229A CR20170229A (en) 2014-12-01 2015-11-30 1- [2- (AMINOMETIL) BENCIL] -2-THIOXO-1,2,3,5-TETRAHYDRO-4H-PIRROLO [3,2-D] PYRIMIDIN-4-ONAS AS MYELOPEROXIDASE INHIBITORS

Country Status (2)

Country Link
AR (1) AR102863A1 (en)
CR (1) CR20170229A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115403584B (en) * 2021-05-26 2024-04-02 长春金赛药业有限责任公司 2-thio-2, 3-dihydropyrimidine-4-one derivatives, pharmaceutical compositions, preparation methods and applications thereof

Also Published As

Publication number Publication date
AR102863A1 (en) 2017-03-29

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