CR20170229A - 1- [2- (AMINOMETIL) BENCIL] -2-THIOXO-1,2,3,5-TETRAHYDRO-4H-PIRROLO [3,2-D] PYRIMIDIN-4-ONAS AS MYELOPEROXIDASE INHIBITORS - Google Patents
1- [2- (AMINOMETIL) BENCIL] -2-THIOXO-1,2,3,5-TETRAHYDRO-4H-PIRROLO [3,2-D] PYRIMIDIN-4-ONAS AS MYELOPEROXIDASE INHIBITORSInfo
- Publication number
- CR20170229A CR20170229A CR20170229A CR20170229A CR20170229A CR 20170229 A CR20170229 A CR 20170229A CR 20170229 A CR20170229 A CR 20170229A CR 20170229 A CR20170229 A CR 20170229A CR 20170229 A CR20170229 A CR 20170229A
- Authority
- CR
- Costa Rica
- Prior art keywords
- thioxo
- pyrimidin
- tetrahydro
- aminometil
- bencil
- Prior art date
Links
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se dan a conocer determinados compuestos de 1-[2-(aminometil)bencil]-2-tioxo-1,2,3,5-tetrahidro-4H-pirrolo[3,2-d]pirimidin-4-ona de fórmula (I),y sales farmacéuticamente aceptable de los mismos, junto con composiciones que los contienen y su uso en terapia. Los compuestos son inhibidores de la enzima MPO y de este modo son particularmente útiles en el tratamiento o profilaxis de trastornos cardiovasculares tales como insuficiencia cardíaca y estados relacionados con arteriopatía coronaria. NHNNHOSR2NHR3R1(I)Certain 1- [2- (aminomethyl) benzyl] -2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo [3,2-d] pyrimidin-4-one compounds of formula ( I), and pharmaceutically acceptable salts thereof, together with compositions containing them and their use in therapy. The compounds are inhibitors of the MPO enzyme and thus are particularly useful in the treatment or prophylaxis of cardiovascular disorders such as heart failure and conditions related to coronary artery disease. NHNNHOSR2NHR3R1 (I)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462085722P | 2014-12-01 | 2014-12-01 | |
PCT/EP2015/077998 WO2016087338A1 (en) | 2014-12-01 | 2015-11-30 | 1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4h-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase |
Publications (1)
Publication Number | Publication Date |
---|---|
CR20170229A true CR20170229A (en) | 2017-09-20 |
Family
ID=58672229
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR20170229A CR20170229A (en) | 2014-12-01 | 2015-11-30 | 1- [2- (AMINOMETIL) BENCIL] -2-THIOXO-1,2,3,5-TETRAHYDRO-4H-PIRROLO [3,2-D] PYRIMIDIN-4-ONAS AS MYELOPEROXIDASE INHIBITORS |
Country Status (2)
Country | Link |
---|---|
AR (1) | AR102863A1 (en) |
CR (1) | CR20170229A (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115403584B (en) * | 2021-05-26 | 2024-04-02 | 长春金赛药业有限责任公司 | 2-thio-2, 3-dihydropyrimidine-4-one derivatives, pharmaceutical compositions, preparation methods and applications thereof |
-
2015
- 2015-11-30 AR ARP150103913A patent/AR102863A1/en active IP Right Grant
- 2015-11-30 CR CR20170229A patent/CR20170229A/en unknown
Also Published As
Publication number | Publication date |
---|---|
AR102863A1 (en) | 2017-03-29 |
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