CR20150300A - N-PIRROLIDINIL, N´-PIRAZOLIL-UREA, TIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS INHIBITORS OF TRKA CINASA - Google Patents
N-PIRROLIDINIL, N´-PIRAZOLIL-UREA, TIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS INHIBITORS OF TRKA CINASAInfo
- Publication number
- CR20150300A CR20150300A CR20150300A CR20150300A CR20150300A CR 20150300 A CR20150300 A CR 20150300A CR 20150300 A CR20150300 A CR 20150300A CR 20150300 A CR20150300 A CR 20150300A CR 20150300 A CR20150300 A CR 20150300A
- Authority
- CR
- Costa Rica
- Prior art keywords
- trka
- inhibitors
- pirrolidinil
- pirazolil
- cinasa
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Compuestos de Fórmula (I) o estereoisómeros, tautómeros, o sales, solvatos o profármacos farmacéuticamente aceptables de estos, donde R1, R2, Ra, Rb, Rc, Rd, X, el anillo B y el anillo C son como se definen en la presente y donde el anillo B y el resto NH-C(=X)-NH se encuentran en la configuración trans, son inhibidores de TrkA cinasa y son útiles en el tratamiento de enfermedades que se pueden tratar con un inhibidor de TrkA cinasa como dolor, cáncer, inflamación/enfermedades inflamatorias, enfermedades neurodegenerativas, algunas enfermedades infecciosas, síndrome de Sjogren, endometriosis, neuropatía periférica diabética, prostatitis o síndrome de dolor pélvico.Compounds of Formula (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, where R1, R2, Ra, Rb, Rc, Rd, X, ring B and ring C are as defined in present and where the B-ring and the NH-C (= X) -NH moiety are in the trans configuration, are TrkA kinase inhibitors and are useful in the treatment of diseases that can be treated with a TrkA kinase inhibitor as pain , cancer, inflammation / inflammatory diseases, neurodegenerative diseases, some infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis or pelvic pain syndrome.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2013/069729 WO2014078323A1 (en) | 2012-11-13 | 2013-11-12 | N-pyrrolidinyl, n'-pyrazolyl- urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors |
| US201361725913P | 2013-11-13 | 2013-11-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR20150300A true CR20150300A (en) | 2015-09-03 |
Family
ID=54834966
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR20150300A CR20150300A (en) | 2013-11-12 | 2015-06-05 | N-PIRROLIDINIL, N´-PIRAZOLIL-UREA, TIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS INHIBITORS OF TRKA CINASA |
Country Status (1)
| Country | Link |
|---|---|
| CR (1) | CR20150300A (en) |
-
2015
- 2015-06-05 CR CR20150300A patent/CR20150300A/en unknown
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