CR20140481A - TRIAZOLO COMPOUNDS AS PDE10 INHIBITORS - Google Patents

TRIAZOLO COMPOUNDS AS PDE10 INHIBITORS

Info

Publication number
CR20140481A
CR20140481A CR20140481A CR20140481A CR20140481A CR 20140481 A CR20140481 A CR 20140481A CR 20140481 A CR20140481 A CR 20140481A CR 20140481 A CR20140481 A CR 20140481A CR 20140481 A CR20140481 A CR 20140481A
Authority
CR
Costa Rica
Prior art keywords
pde10 inhibitors
compounds
triazolo compounds
triazolo
pde10
Prior art date
Application number
CR20140481A
Other languages
Spanish (es)
Inventor
Alexander Flohr
Zbinden Katrin Groebke
Bernd Kuhn
Christian Lerner
Markus Rudolph
Herve Schaffhauser
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48534382&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR20140481(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CR20140481A publication Critical patent/CR20140481A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

La presente invención proporciona compuestos de las fórmulas (Ia) y (Ib) en las que R1, R2, R3 y R4 tienen los significados definidos en la descripción y en las reivindicaciones, y también sales farmacéuticamente aceptables de los mismos. Estos compuestos inhiben la PDE10A y pueden utilizarse como medicamentos.The present invention provides compounds of the formulas (Ia) and (Ib) in which R1, R2, R3 and R4 have the meanings defined in the description and in the claims, and also pharmaceutically acceptable salts thereof. These compounds inhibit PDE10A and can be used as medicines.

CR20140481A 2012-05-30 2014-10-16 TRIAZOLO COMPOUNDS AS PDE10 INHIBITORS CR20140481A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12169954 2012-05-30
PCT/EP2013/060838 WO2013178572A1 (en) 2012-05-30 2013-05-27 Triazolo compounds as pde10 inhibitors

Publications (1)

Publication Number Publication Date
CR20140481A true CR20140481A (en) 2014-11-17

Family

ID=48534382

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20140481A CR20140481A (en) 2012-05-30 2014-10-16 TRIAZOLO COMPOUNDS AS PDE10 INHIBITORS

Country Status (21)

Country Link
US (1) US9394311B2 (en)
EP (1) EP2855455B1 (en)
JP (1) JP5992096B2 (en)
KR (1) KR101666293B1 (en)
CN (1) CN104364249B (en)
AR (1) AR091185A1 (en)
AU (1) AU2013269800A1 (en)
BR (1) BR112014026828A2 (en)
CA (1) CA2868240A1 (en)
CL (1) CL2014002847A1 (en)
CO (1) CO7091174A2 (en)
CR (1) CR20140481A (en)
EA (1) EA201492069A1 (en)
IL (1) IL235829A0 (en)
MX (1) MX2014014468A (en)
PE (1) PE20142366A1 (en)
PH (1) PH12014502294A1 (en)
SG (1) SG11201406890YA (en)
TW (1) TW201402564A (en)
WO (1) WO2013178572A1 (en)
ZA (1) ZA201407695B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2015005375A (en) * 2012-11-07 2015-07-21 Hoffmann La Roche Triazolo compounds.
US10723723B2 (en) 2016-11-03 2020-07-28 Bristol-Myers Squibb Company Substituted bicycle heterocyclic derivatives useful as ROMK channel inhibitors
CN109666022B (en) * 2017-10-17 2021-06-15 中国科学院上海药物研究所 Triazole derivative and preparation method and application thereof
JP7474709B2 (en) 2018-02-27 2024-04-25 インサイト・コーポレイション Imidazopyrimidines and triazolopyrimidines as A2A/A2B inhibitors
US11168089B2 (en) 2018-05-18 2021-11-09 Incyte Corporation Fused pyrimidine derivatives as A2A / A2B inhibitors
GEP20237560B (en) 2018-07-05 2023-10-25 Incyte Corp Fused pyrazine derivatives as a2a / a2b inhibitors
TW202031250A (en) 2018-11-06 2020-09-01 丹麥商Ｈ 朗德貝克公司 Pde10a inhibitors for treating negative symptoms and cognitive impairments
WO2020094592A1 (en) 2018-11-06 2020-05-14 H. Lundbeck A/S Compounds for treating negative symptoms and cognitive impairments
TWI829857B (en) 2019-01-29 2024-01-21 美商英塞特公司 Pyrazolopyridines and triazolopyridines as a2a / a2b inhibitors
TWI769532B (en) * 2019-09-25 2022-07-01 波蘭商昂科艾倫迪治療法股份公司 Process for the production of 5-(4-((2s,5s)-5-(4-chlorobenzyl)-2-methylmorpholino)piperidin-1-yl)-1h-1,2,4-triazol-3-amine
CN113929634A (en) * 2021-11-22 2022-01-14 山西永津集团有限公司 Synthesis method of 2, 3-dibromoquinoxaline

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2744116A (en) * 1953-12-04 1956-05-01 Purdue Research Foundation Bis-(aminotriazolyl-)-hydrocarbons
AR022229A1 (en) * 1999-01-12 2002-09-04 Abbott Gmbh & Co Kg TRIAZOL COMPOUNDS, PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM AND USE OF THE SAME TO PREPARE SUCH COMPOSITION
US6887870B1 (en) * 1999-10-12 2005-05-03 Bristol-Myers Squibb Company Heterocyclic sodium/proton exchange inhibitors and method
WO2005012485A2 (en) 2003-07-31 2005-02-10 Bayer Pharmaceuticals Corporation Methods for treating diabetes and related disorders using pde10a inhibitors
CA2608718A1 (en) * 2005-05-18 2006-11-23 Pfizer Limited 1, 2, 4-triazole derivatives as vasopressin antagonists
DE602006018151D1 (en) * 2005-08-10 2010-12-23 Glaxosmithkline Llc XANTHINE DERIVATIVES AS SELECTIVE HM74A AGONISTS
WO2008103357A1 (en) * 2007-02-21 2008-08-28 E. I. Du Pont De Nemours And Company Fungicidal tricyclic 1,2,4-triazoles
CN101678014B (en) * 2007-05-21 2012-12-12 Sgx药品公司 Heterocyclic kinase modulators
TWI501965B (en) 2008-06-20 2015-10-01 Lundbeck & Co As H Novel phenylimidazole derivatives as pde10a enzyme inhibitors
TWI487705B (en) * 2009-12-17 2015-06-11 Lundbeck & Co As H Heteroaromatic aryl triazole derivatives as pde10a enzyme inhibitors
AU2011258217B2 (en) 2010-05-26 2016-12-15 Sunovion Pharmaceuticals Inc. Heteroaryl compounds and methods of use thereof
AP2012006631A0 (en) * 2010-08-12 2012-12-31 Boehringer Ingelheim Int 6-Cycloalkyl-1, 5-dihydro-pyrazolo[3,4-D] pyrimidin-4-one derivatives and their use as PDE9A inhibitors
US20130225583A1 (en) * 2010-10-21 2013-08-29 Gerald W. Shipps, Jr. Substituted amino-triazolyl pde10 inhibitors

Also Published As

Publication number Publication date
TW201402564A (en) 2014-01-16
EP2855455B1 (en) 2017-11-08
PH12014502294A1 (en) 2014-12-15
EA201492069A1 (en) 2015-03-31
US9394311B2 (en) 2016-07-19
JP5992096B2 (en) 2016-09-14
KR20150027143A (en) 2015-03-11
CA2868240A1 (en) 2013-12-05
CN104364249B (en) 2018-04-17
WO2013178572A1 (en) 2013-12-05
CN104364249A (en) 2015-02-18
CO7091174A2 (en) 2014-10-21
CL2014002847A1 (en) 2015-01-30
ZA201407695B (en) 2016-08-31
EP2855455A1 (en) 2015-04-08
KR101666293B1 (en) 2016-10-13
MX2014014468A (en) 2015-02-12
BR112014026828A2 (en) 2017-06-27
AU2013269800A1 (en) 2014-10-09
AR091185A1 (en) 2015-01-14
PE20142366A1 (en) 2015-01-10
SG11201406890YA (en) 2014-11-27
US20150148332A1 (en) 2015-05-28
JP2015518018A (en) 2015-06-25
IL235829A0 (en) 2015-02-01

Similar Documents

Publication Publication Date Title
CR20140481A (en) TRIAZOLO COMPOUNDS AS PDE10 INHIBITORS
GT201400196A (en) HETEROCICLYL COMPOUNDS
CR20120443A (en) DERIVATIVES OF (IMIDAZOPIRIMIDINA-7-IL) -HETEROARILAMIDA AND ITS USE AS PDE10A INHIBITORS
GT201500094A (en) PIRROLOTRIAZINONA DERIVATIVES AS PI3K INHIBITORS
DOP2015000108A (en) PIRROLOPIRIMIDINE COMPOUNDS AS QUINASE INHIBITORS
CR20150524A (en) HETEROARILO COMPOUNDS AND ITS USES
CR20130239A (en) TRIAZOLOPIRIDINE COMPOUNDS
CO6630162A2 (en) 1-amino -2-cyclopropylethylboronic acid derivatives
CR20140106A (en) COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF THE QUINASE C-KIT
CL2013000603A1 (en) Compounds derived from quinoline and quinoxaline, pi3k inhibitors; pharmaceutical composition that includes them; and its use in the treatment of an inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nocicenoiceptive and ophthalmic disease.
EA201391285A1 (en) Derivatives of tetrahydroquinoline, useful as bromodomain inhibitors
CR20150250A (en) NEW DERIVATIVES OF PIRIDINA
CL2014001829A1 (en) Compounds derived from indolizine; preparation procedure; pharmaceutical compositions containing them and use in the treatment of cancer.
UY33440A (en) ? PYRIMIDINYL COMPOUNDS FOR USE AS ATR INHIBITORS ?.
DOP2014000036A (en) PIRIDAZINONE COMPOUNDS AND ITS USE AS DAAO INHIBITORS
UY34220A (en) INDAZOLS, PHARMACEUTICAL COMPOSITIONS AND USE OF THE SAME
CR20140275A (en) SUBSTITUTED TRIAZOLOPIRIDINS
CR20160076A (en) NEW DERIVATIVES OF TRIAZOLO [4,5-d] PYRIMIDINE
UY34779A (en) ANTI-IL-23 ANTIBODIES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
NI201500096A (en) CHEMICAL COMPOUNDS
EA201490599A1 (en) TRIAZOLOPIRIDINE COMPOUNDS AS INHIBITORS OF PHOSPHODYSTTERASE PDE10A
CR20150133A (en) AMINO-QUINOLINAS AS KINASE INHIBITORS
UY35087A (en) PIRROLOTRIAZINONA DERIVATIVES AS PI3K INHIBITORS
UY35332A (en) PIRROLOTRIAZINE DERIVATIVES AS PI3K INHIBITORS
UY34761A (en) PARASITICIDE COMPOSITIONS THAT INCLUDE DERIVATIVES OF BENZIMIDAZOL, METHODS AND USES OF THE SAME.