CR20140095A - AN ANTIGEN-SPECIFIC CA6 CYTOTOXIC CONJUGATE AND METHODS TO USE THE SAME - Google Patents
AN ANTIGEN-SPECIFIC CA6 CYTOTOXIC CONJUGATE AND METHODS TO USE THE SAMEInfo
- Publication number
- CR20140095A CR20140095A CR20140095A CR20140095A CR20140095A CR 20140095 A CR20140095 A CR 20140095A CR 20140095 A CR20140095 A CR 20140095A CR 20140095 A CR20140095 A CR 20140095A CR 20140095 A CR20140095 A CR 20140095A
- Authority
- CR
- Costa Rica
- Prior art keywords
- methods
- cytotoxic
- antigen
- specific
- same
- Prior art date
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
Se describen conjugados citotóxicos que comprenden un agente de enlace celular y un agente citotóxico, composiciones terapéuticas que comprenden el conjugado, métodos para usar los conjugados en la inhibición del crecimiento celular y el tratamiento de la enfermedad, y un equipo de comprende el conjugado citotóxico en todas las modalidades de la invención. En particular, el agente de enlace celular es un anticuerpo monoclonal, y fragmentos de enlace de epítope del mismo, que reconoce y enlaza el glicótopo CA6. La presente invención también está dirigida a versiones humanizadas o recubiertas de DS6, un anticuerpo monoclonal anti-CA6 murino, y fragmentos de enlace de epítope del mismo.Cytotoxic conjugates comprising a cell binding agent and a cytotoxic agent, therapeutic compositions comprising the conjugate, methods for using the conjugates in the inhibition of cell growth and treatment of the disease, and a kit comprising the cytotoxic conjugate are described in all embodiments of the invention. In particular, the cell binding agent is a monoclonal antibody, and epitope binding fragments thereof, which recognizes and binds the CA6 glycopepo. The present invention is also directed to humanized or coated versions of DS6, a murine anti-CA6 monoclonal antibody, and epitope binding fragments thereof.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CR20140095A CR20140095A (en) | 2014-02-26 | 2014-02-26 | AN ANTIGEN-SPECIFIC CA6 CYTOTOXIC CONJUGATE AND METHODS TO USE THE SAME |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CR20140095A CR20140095A (en) | 2014-02-26 | 2014-02-26 | AN ANTIGEN-SPECIFIC CA6 CYTOTOXIC CONJUGATE AND METHODS TO USE THE SAME |
Publications (1)
Publication Number | Publication Date |
---|---|
CR20140095A true CR20140095A (en) | 2014-03-28 |
Family
ID=51359547
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR20140095A CR20140095A (en) | 2014-02-26 | 2014-02-26 | AN ANTIGEN-SPECIFIC CA6 CYTOTOXIC CONJUGATE AND METHODS TO USE THE SAME |
Country Status (1)
Country | Link |
---|---|
CR (1) | CR20140095A (en) |
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2014
- 2014-02-26 CR CR20140095A patent/CR20140095A/en unknown
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