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Application filed by Oncomed Pharm IncfiledCriticalOncomed Pharm Inc
Priority to CR20110070ApriorityCriticalpatent/CR20110070A/en
Publication of CR20110070ApublicationCriticalpatent/CR20110070A/en
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents
(AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines
(AREA)
Abstract
El presente invento se relaciona con agentes fijadores de Notch y antagonistas de la proteína Notch y métodos para el uso de los agentes y/o antagonistas para el tratamiento de enfermedades como el cáncer. El presente invento suministra anticuerpos los cuales se fijan de manera específica a una región no fijadora de ligandos del dominio extracelular de uno o más receptores Notch humanos, como Notch2 y/o Notch3, e inhiben el crecimiento tumoral.The present invention relates to Notch fixing agents and Notch protein antagonists and methods for the use of agents and / or antagonists for the treatment of diseases such as cancer. The present invention provides antibodies which specifically bind to a non-binding region of extracellular domain ligands of one or more human Notch receptors, such as Notch2 and / or Notch3, and inhibit tumor growth.
CR20110070A2011-02-072011-02-07
Notch fixing agents and antagonists and methods for their use
CR20110070A
(en)