CO7170129A2 - Methods and compositions to modulate notch activity - Google Patents
Methods and compositions to modulate notch activityInfo
- Publication number
- CO7170129A2 CO7170129A2 CO14238362A CO14238362A CO7170129A2 CO 7170129 A2 CO7170129 A2 CO 7170129A2 CO 14238362 A CO14238362 A CO 14238362A CO 14238362 A CO14238362 A CO 14238362A CO 7170129 A2 CO7170129 A2 CO 7170129A2
- Authority
- CO
- Colombia
- Prior art keywords
- compositions
- methods
- polypeptides
- notch activity
- modulate notch
- Prior art date
Links
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
En la presente se proporcionan los polipéptidos y derivados de estos que contienen secuencias de una proteína Serrate y que inhiben la función de la vía de Notch. También se proporcionan en la presente los ácidos nucleicos que codifican los polipéptidos, vectores y células para producir los polipéptidos, y las composiciones farmacéuticas y kits relacionados. Además se proporcionan los anticuerpos que se unen a la región de inhibición de Notch de una proteína Serrate. También se proporcionan métodos terapéuticos.Polypeptides and derivatives thereof are provided herein that contain sequences of a Serrate protein and that inhibit the function of the Notch pathway. Nucleic acids encoding the polypeptides, vectors and cells to produce the polypeptides, and related pharmaceutical compositions and kits are also provided herein. In addition, antibodies that bind to the Notch inhibition region of a Serrate protein are provided. Therapeutic methods are also provided.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CO14238362A CO7170129A2 (en) | 2014-10-28 | 2014-10-28 | Methods and compositions to modulate notch activity |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CO14238362A CO7170129A2 (en) | 2014-10-28 | 2014-10-28 | Methods and compositions to modulate notch activity |
Publications (1)
Publication Number | Publication Date |
---|---|
CO7170129A2 true CO7170129A2 (en) | 2015-01-28 |
Family
ID=52623074
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO14238362A CO7170129A2 (en) | 2014-10-28 | 2014-10-28 | Methods and compositions to modulate notch activity |
Country Status (1)
Country | Link |
---|---|
CO (1) | CO7170129A2 (en) |
-
2014
- 2014-10-28 CO CO14238362A patent/CO7170129A2/en unknown
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1124834T1 (en) | INHIBITORS OF THE MINE-MLL INTERACTION | |
PE20190563A1 (en) | OPTIMIZED MINI-DISTROPHIN GENES AND EXPRESSION CASSETS AND THEIR USE | |
CL2017003023A1 (en) | Anti-ctla-4 antibodies and methods of use thereof. | |
BR112018012707A2 (en) | menin-mll interaction inhibitors | |
CL2018000595A1 (en) | Anti-PD1 antibodies and methods of use | |
CL2017001204A1 (en) | 6-amino-7-bicyclo-7-deaza-purine derivatives as protein kinase inhibitors | |
CO2017004525A2 (en) | Ror-gamma inhibitory dihydropyrrolopyridines | |
BR112017012679A2 (en) | immunomodulatory compounds, their uses, composition and kit | |
BR112018003186A2 (en) | anti-pd-1 antibodies and their methods of use | |
BR112018011133A2 (en) | Therapeutic Targets for the Correction of the Human Dystrophin Gene by Gene Editing and Methods of Use | |
UY35964A (en) | HUMAN ANTIBODIES FOR PD? 1 | |
EA201691582A1 (en) | NEW PHARMACEUTICAL PREPARATIONS | |
EA201790785A1 (en) | Derivatives of tetrahydroisoquinoline | |
BR112019000693A2 (en) | mucocharge compositions and methods for use | |
CL2018001722A1 (en) | New anti-mfi2 antibodies and methods of use (divisional application 201700506) | |
BR112015023417A2 (en) | heterocyclic compounds and their uses | |
MX2020004801A (en) | Bispecific fusion polypeptides and methods of use thereof. | |
CL2018001565A1 (en) | C-terminal lysine conjugated immunoglobulins | |
CY1124195T1 (en) | COMPLEMENTARY THERAPEUTIC FORMULATIONS FOR SEQUENTIAL OR SEPARATE ADMINISTRATION OF BUTYRIC ACID AND PROBIOTICS | |
BR112018071370A2 (en) | mesalazine oral pharmaceutical compositions | |
DOP2016000297A (en) | PHARMACEUTICAL COMPOSITIONS USEFUL TO TREAT INFECTIOUS DISEASES | |
AR101486A1 (en) | ANTIBODIES ANTI PROTEIN SIMILAR TO ANGIOPOYETINA 4 AND METHODS OF USE | |
AR101671A1 (en) | ANTIBODIES ANTI PROTEIN SIMILAR TO ANGIOPOYETINA-4 (ANGPTL4) AND METHODS OF USE | |
BR112016019390A2 (en) | fusion proteins uti | |
AR112069A1 (en) | IMMUNOGLOBULINS THAT BIND AGGRECAN |