CO7170129A2 - Methods and compositions to modulate notch activity - Google Patents

Methods and compositions to modulate notch activity

Info

Publication number
CO7170129A2
CO7170129A2 CO14238362A CO14238362A CO7170129A2 CO 7170129 A2 CO7170129 A2 CO 7170129A2 CO 14238362 A CO14238362 A CO 14238362A CO 14238362 A CO14238362 A CO 14238362A CO 7170129 A2 CO7170129 A2 CO 7170129A2
Authority
CO
Colombia
Prior art keywords
compositions
methods
polypeptides
notch activity
modulate notch
Prior art date
Application number
CO14238362A
Other languages
Spanish (es)
Inventor
Robert J Fleming
Spyridon Artavanistsakonas
Original Assignee
Robert J Fleming
Spyridon Artavanistsakonas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Robert J Fleming, Spyridon Artavanistsakonas filed Critical Robert J Fleming
Priority to CO14238362A priority Critical patent/CO7170129A2/en
Publication of CO7170129A2 publication Critical patent/CO7170129A2/en

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

En la presente se proporcionan los polipéptidos y derivados de estos que contienen secuencias de una proteína Serrate y que inhiben la función de la vía de Notch. También se proporcionan en la presente los ácidos nucleicos que codifican los polipéptidos, vectores y células para producir los polipéptidos, y las composiciones farmacéuticas y kits relacionados. Además se proporcionan los anticuerpos que se unen a la región de inhibición de Notch de una proteína Serrate. También se proporcionan métodos terapéuticos.Polypeptides and derivatives thereof are provided herein that contain sequences of a Serrate protein and that inhibit the function of the Notch pathway. Nucleic acids encoding the polypeptides, vectors and cells to produce the polypeptides, and related pharmaceutical compositions and kits are also provided herein. In addition, antibodies that bind to the Notch inhibition region of a Serrate protein are provided. Therapeutic methods are also provided.

CO14238362A 2014-10-28 2014-10-28 Methods and compositions to modulate notch activity CO7170129A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CO14238362A CO7170129A2 (en) 2014-10-28 2014-10-28 Methods and compositions to modulate notch activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CO14238362A CO7170129A2 (en) 2014-10-28 2014-10-28 Methods and compositions to modulate notch activity

Publications (1)

Publication Number Publication Date
CO7170129A2 true CO7170129A2 (en) 2015-01-28

Family

ID=52623074

Family Applications (1)

Application Number Title Priority Date Filing Date
CO14238362A CO7170129A2 (en) 2014-10-28 2014-10-28 Methods and compositions to modulate notch activity

Country Status (1)

Country Link
CO (1) CO7170129A2 (en)

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