CO7160072A2 - Synthesis of heterocyclic compounds - Google Patents
Synthesis of heterocyclic compoundsInfo
- Publication number
- CO7160072A2 CO7160072A2 CO14278717A CO14278717A CO7160072A2 CO 7160072 A2 CO7160072 A2 CO 7160072A2 CO 14278717 A CO14278717 A CO 14278717A CO 14278717 A CO14278717 A CO 14278717A CO 7160072 A2 CO7160072 A2 CO 7160072A2
- Authority
- CO
- Colombia
- Prior art keywords
- compounds
- deleishmaniasis
- quaternary ammonium
- ammonium salts
- halogenated
- Prior art date
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Sales de amonio cuaternario halogenado son descritas para tratar infecciones deleishmaniasis y otras infecciones parasitarias. Aunque se han descrito los informesanteriores en los que las sales de amonio cuaternarios se usan como compuestosantimalarios, antifungicos, y antileishmaniales, no se ha reportado el uso de talessales que contienen un sustituto de N-metilo halogenado como agente terapéutico contra la leishmaniasis. Los compuestos aquí descritos, específicamente aquellos conporción terminal de arilalquenilo o diarilalquenilo, inhiben el crecimiento de losparásitos Leishmania panamensis, un agente conocido por causar la enfermedad deleishmaniasis. Adicionalmente, la serie de compuestos también se extiende contra lamalaria, la Enfermedad de Chagas, la toxoplasmosis, y otras enfermedadesparasitarias.Halogenated quaternary ammonium salts are described to treat deleishmaniasis infections and other parasitic infections. Although the above reports have been described in which quaternary ammonium salts are used as antimalarial, antifungal, and antileishmanial compounds, the use of talsales containing a halogenated N-methyl substitute as a therapeutic agent against leishmaniasis has not been reported. The compounds described herein, specifically those terminal proportions of arylalkenyl or diarylalkenyl, inhibit the growth of Leishmania panamensis parasites, an agent known to cause deleishmaniasis disease. Additionally, the series of compounds also extends against lamalaria, Chagas disease, toxoplasmosis, and other parasitic diseases.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261653944P | 2012-05-31 | 2012-05-31 | |
| US13/793,917 US9150570B2 (en) | 2012-05-31 | 2013-03-11 | Synthesis of heterocyclic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO7160072A2 true CO7160072A2 (en) | 2015-01-15 |
Family
ID=52623072
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO14278717A CO7160072A2 (en) | 2012-05-31 | 2014-12-18 | Synthesis of heterocyclic compounds |
Country Status (1)
| Country | Link |
|---|---|
| CO (1) | CO7160072A2 (en) |
-
2014
- 2014-12-18 CO CO14278717A patent/CO7160072A2/en unknown
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