CO6670557A2 - A new colony-stimulating granulocyte conjugate factor (g-csf) with polyethylene - Google Patents
A new colony-stimulating granulocyte conjugate factor (g-csf) with polyethyleneInfo
- Publication number
- CO6670557A2 CO6670557A2 CO13009151A CO13009151A CO6670557A2 CO 6670557 A2 CO6670557 A2 CO 6670557A2 CO 13009151 A CO13009151 A CO 13009151A CO 13009151 A CO13009151 A CO 13009151A CO 6670557 A2 CO6670557 A2 CO 6670557A2
- Authority
- CO
- Colombia
- Prior art keywords
- csf
- conjugate
- polyethylene
- formula
- new colony
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invención se relaciona a farmacéuticos y medicina, específicamente, a un nuevo conjugado fisiológicamente de granulocita colonia estimulante factor (G-CSF) con la fórmula general:Donde:n - intergers de 681 a 1 000; m – interger = 4;NH-G-CSF - Natural o recombinante polipéptido, teniendo actividad de G-CSFLa invención también está relacionada a medicinas conteniendo el conjugado reclamado de fórmula (1), composiciones farmacéuticas, el uso de conjugado de fórmula (1) para drogas y medicinas con granulocita colonia estimulante factor como un ingrediente activo, se aproxima a prevenir y/o tratar la neutropenia, el contenedor que contiene la composición farmacéutica.The present invention relates to pharmacists and medicine, specifically, to a new physiologically conjugated granulocyte colony stimulating factor (G-CSF) with the general formula: Where: n - intergers from 681 to 1 000; m - interger = 4; NH-G-CSF - Natural or recombinant polypeptide, having G-CSF activity The invention is also related to medicines containing the claimed conjugate of formula (1), pharmaceutical compositions, the use of conjugate of formula (1 ) For drugs and medicines with granulocyte colony stimulating factor as an active ingredient, it comes close to preventing and / or treating neutropenia, the container that contains the pharmaceutical composition.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2010133875/10A RU2446173C1 (en) | 2010-08-13 | 2010-08-13 | New functional, high-purity stable conjugate of granulocyte colony-stimulating factor (g-csf) and polyethylene glycol with prolonged biological action, applicable for medical purposes, and based immunobiological agent |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6670557A2 true CO6670557A2 (en) | 2013-05-15 |
Family
ID=45567857
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO13009151A CO6670557A2 (en) | 2010-08-13 | 2013-01-18 | A new colony-stimulating granulocyte conjugate factor (g-csf) with polyethylene |
Country Status (17)
Country | Link |
---|---|
KR (1) | KR101549457B1 (en) |
CN (1) | CN103140499B (en) |
CL (1) | CL2013000400A1 (en) |
CO (1) | CO6670557A2 (en) |
CR (1) | CR20130020A (en) |
CU (1) | CU24139B1 (en) |
DO (1) | DOP2013000003A (en) |
EA (1) | EA019043B1 (en) |
EC (1) | ECSP13012399A (en) |
MA (1) | MA34525B1 (en) |
MY (1) | MY160732A (en) |
NI (1) | NI201300007A (en) |
PE (1) | PE20131085A1 (en) |
RS (1) | RS20130094A1 (en) |
RU (1) | RU2446173C1 (en) |
SG (1) | SG187572A1 (en) |
WO (1) | WO2012021088A1 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012110057A1 (en) | 2011-02-15 | 2012-08-23 | Chemisches Institut Schaefer Ag | Cefuroxime safety kit |
WO2013185105A1 (en) | 2012-06-07 | 2013-12-12 | Children's Hospital Los Angeles | Methods for treating neutropenia using retinoid agonists |
CN103908427B (en) * | 2013-01-05 | 2014-12-17 | 石药集团百克(山东)生物制药有限公司 | Polyethylene glycol modified rhG-CSF injection and preparation method thereof |
RU2535002C2 (en) * | 2013-04-04 | 2014-12-10 | Федеральное государственное бюджетное учреждение "Научно-исследовательский институт фармакологии" Сибирского отделения Российской академии медицинских наук | Method for correction of remote consequences of spermatogenesis caused by cytostatic exposure |
CN106413701A (en) | 2014-02-18 | 2017-02-15 | 洛杉矶儿童医院 | Compositions and methods for treating neutropenia |
EA035448B1 (en) * | 2014-07-14 | 2020-06-17 | Геннова Биофармасьютикалз Лимитед | PROCESS FOR PURIFICATION OF rHu-GCSF |
IL247369B (en) * | 2016-08-18 | 2018-08-30 | B G Negev Tech And Applications Ltd | Modified m-csf polypeptides and use thereof |
KR102020995B1 (en) * | 2017-10-30 | 2019-09-16 | 한국코러스 주식회사 | A method of preparing gcsf and polyol_conjugated conjugates with high yield |
CN115297844A (en) * | 2020-03-17 | 2022-11-04 | 德拉格雷丘尔公司 | Liquid formulation of GM-CSF for inhalation |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2006596C (en) * | 1988-12-22 | 2000-09-05 | Rika Ishikawa | Chemically-modified g-csf |
US5252714A (en) * | 1990-11-28 | 1993-10-12 | The University Of Alabama In Huntsville | Preparation and use of polyethylene glycol propionaldehyde |
US5824784A (en) * | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
KR20040083268A (en) * | 2003-03-21 | 2004-10-01 | 한미약품 주식회사 | Human granulocyte-colony stimulating factor conjugate having enhanced stability in blood and process for the preparation thereof |
RU2278870C2 (en) * | 2004-08-30 | 2006-06-27 | Закрытое Акционерное Общество "Биокад" | Method for preparing, isolating, purifying and stabilizing human recombinant granulocytic colony-stimulating factor useful for medicinal using and immunobiological agent based on thereof |
US20070196416A1 (en) * | 2006-01-18 | 2007-08-23 | Quest Pharmaceutical Services | Pharmaceutical compositions with enhanced stability |
US8840882B2 (en) * | 2006-06-23 | 2014-09-23 | Quintessence Biosciences, Inc. | Modified ribonucleases |
-
2010
- 2010-08-13 RU RU2010133875/10A patent/RU2446173C1/en active
-
2011
- 2011-07-19 CU CU20130012A patent/CU24139B1/en unknown
- 2011-07-19 SG SG2013004544A patent/SG187572A1/en unknown
- 2011-07-19 MY MYPI2013000217A patent/MY160732A/en unknown
- 2011-07-19 KR KR1020137001860A patent/KR101549457B1/en not_active IP Right Cessation
- 2011-07-19 CN CN201180044089.6A patent/CN103140499B/en not_active Expired - Fee Related
- 2011-07-19 WO PCT/RU2011/000532 patent/WO2012021088A1/en active Application Filing
- 2011-07-19 MA MA35731A patent/MA34525B1/en unknown
- 2011-07-19 RS RS20130094A patent/RS20130094A1/en unknown
- 2011-07-19 PE PE2013000083A patent/PE20131085A1/en not_active Application Discontinuation
- 2011-08-01 EA EA201101035A patent/EA019043B1/en not_active IP Right Cessation
-
2013
- 2013-01-04 DO DO2013000003A patent/DOP2013000003A/en unknown
- 2013-01-18 CO CO13009151A patent/CO6670557A2/en unknown
- 2013-01-18 EC ECSP13012399 patent/ECSP13012399A/en unknown
- 2013-01-18 NI NI201300007A patent/NI201300007A/en unknown
- 2013-01-18 CR CR20130020A patent/CR20130020A/en unknown
- 2013-02-08 CL CL2013000400A patent/CL2013000400A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
CU20130012A7 (en) | 2013-04-19 |
EA201101035A1 (en) | 2012-02-28 |
CU24139B1 (en) | 2015-12-23 |
KR20130043167A (en) | 2013-04-29 |
DOP2013000003A (en) | 2013-07-31 |
WO2012021088A1 (en) | 2012-02-16 |
ECSP13012399A (en) | 2013-05-31 |
KR101549457B1 (en) | 2015-09-02 |
CN103140499B (en) | 2014-12-17 |
MA34525B1 (en) | 2013-09-02 |
MY160732A (en) | 2017-03-15 |
PE20131085A1 (en) | 2013-10-10 |
EA019043B1 (en) | 2013-12-30 |
SG187572A1 (en) | 2013-03-28 |
CL2013000400A1 (en) | 2013-07-26 |
CN103140499A (en) | 2013-06-05 |
RS20130094A1 (en) | 2013-08-30 |
RU2446173C1 (en) | 2012-03-27 |
NI201300007A (en) | 2014-05-26 |
CR20130020A (en) | 2013-02-20 |
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