CO6551663A2 - AGOMELATINE HYDROCHLORIDE HYDROCHLORIDE AND PREPARATION OF THIS - Google Patents

AGOMELATINE HYDROCHLORIDE HYDROCHLORIDE AND PREPARATION OF THIS

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Publication number
CO6551663A2
CO6551663A2 CO12158743A CO12158743A CO6551663A2 CO 6551663 A2 CO6551663 A2 CO 6551663A2 CO 12158743 A CO12158743 A CO 12158743A CO 12158743 A CO12158743 A CO 12158743A CO 6551663 A2 CO6551663 A2 CO 6551663A2
Authority
CO
Colombia
Prior art keywords
hydrochloride
agomelatine
preparation
present method
hydrate
Prior art date
Application number
CO12158743A
Other languages
Spanish (es)
Inventor
Hanbin Shan
Zhedong Yuan
Xueyan Zhu
Peng Zhang
Hongjuan Pan
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Priority to CO12158743A priority Critical patent/CO6551663A2/en
Publication of CO6551663A2 publication Critical patent/CO6551663A2/en

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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Se proporciona un hidrato del hidrocloruro de agomelatina de fórmula (I), en la que X es CI, preparación, uso y composición farmacéutica del mismo. Dicho hidrato obtenido mediante el presente método tiene una solubilidad significativamente aumentada que la agomelatina, y por ello es más adecuada para fabricar formulaciones farmacéuticas. Usando el presente método, se puede obtener una pureza elevada mediante de un proceso simple, sin ninguna etapa complicada.An agomelatine hydrochloride hydrate of formula (I) is provided, wherein X is CI, preparation, use and pharmaceutical composition thereof. Said hydrate obtained by the present method has a significantly increased solubility than agomelatine, and is therefore more suitable for manufacturing pharmaceutical formulations. Using the present method, high purity can be obtained by a simple process, without any complicated stage.

CO12158743A 2012-09-14 2012-09-14 AGOMELATINE HYDROCHLORIDE HYDROCHLORIDE AND PREPARATION OF THIS CO6551663A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CO12158743A CO6551663A2 (en) 2012-09-14 2012-09-14 AGOMELATINE HYDROCHLORIDE HYDROCHLORIDE AND PREPARATION OF THIS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CO12158743A CO6551663A2 (en) 2012-09-14 2012-09-14 AGOMELATINE HYDROCHLORIDE HYDROCHLORIDE AND PREPARATION OF THIS

Publications (1)

Publication Number Publication Date
CO6551663A2 true CO6551663A2 (en) 2012-10-31

Family

ID=47566194

Family Applications (1)

Application Number Title Priority Date Filing Date
CO12158743A CO6551663A2 (en) 2012-09-14 2012-09-14 AGOMELATINE HYDROCHLORIDE HYDROCHLORIDE AND PREPARATION OF THIS

Country Status (1)

Country Link
CO (1) CO6551663A2 (en)

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