CO6290692A2 - CYTOTOXIC AGENTS UNDERSTANDING NEW TOMAIMYCIN DERIVATIVES AND THERAPEUTIC USE - Google Patents

CYTOTOXIC AGENTS UNDERSTANDING NEW TOMAIMYCIN DERIVATIVES AND THERAPEUTIC USE

Info

Publication number
CO6290692A2
CO6290692A2 CO10004826A CO10004826A CO6290692A2 CO 6290692 A2 CO6290692 A2 CO 6290692A2 CO 10004826 A CO10004826 A CO 10004826A CO 10004826 A CO10004826 A CO 10004826A CO 6290692 A2 CO6290692 A2 CO 6290692A2
Authority
CO
Colombia
Prior art keywords
tomaimycin
therapeutic use
cytotoxic agents
derivatives
tomaimycin derivatives
Prior art date
Application number
CO10004826A
Other languages
Spanish (es)
Inventor
Herve Bouchard
Ravi V J Chari
Alain Commercon
Yonghong Deng
Laurence Gauzy
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39048765&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6290692(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of CO6290692A2 publication Critical patent/CO6290692A2/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

La invención se refiere a nuevos derivados de tomaimicina que comprenden un ligante. También se refiere a las moléculas de conjugado que comprenden uno o más de dichos derivados de tomaimicina unidos mediante enlaces covalentes a un agente de unión a la célula por un grupo de enlace que está presente en el ligante del derivado de tomaimicina. También se refiere a la preparación de los derivados de tomaimicina y de las moléculas de conjugado.The invention relates to novel tomaimycin derivatives comprising a binder. It also refers to the conjugate molecules comprising one or more of said tomaimycin derivatives linked by covalent bonds to a cell binding agent by a linking group that is present in the binder of the tomaimycin derivative. It also refers to the preparation of tomaimycin derivatives and conjugate molecules.

CO10004826A 2007-07-19 2010-01-19 CYTOTOXIC AGENTS UNDERSTANDING NEW TOMAIMYCIN DERIVATIVES AND THERAPEUTIC USE CO6290692A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07290904.7A EP2019104B1 (en) 2007-07-19 2007-07-19 Cytotoxic agents comprising new tomaymycin derivatives and their therapeutic use

Publications (1)

Publication Number Publication Date
CO6290692A2 true CO6290692A2 (en) 2011-06-20

Family

ID=39048765

Family Applications (1)

Application Number Title Priority Date Filing Date
CO10004826A CO6290692A2 (en) 2007-07-19 2010-01-19 CYTOTOXIC AGENTS UNDERSTANDING NEW TOMAIMYCIN DERIVATIVES AND THERAPEUTIC USE

Country Status (40)

Country Link
US (1) US8404678B2 (en)
EP (2) EP2019104B1 (en)
JP (1) JP5551070B2 (en)
KR (1) KR101627871B1 (en)
CN (1) CN101784550B (en)
AR (1) AR067575A1 (en)
AT (1) ATE530553T1 (en)
AU (1) AU2008281439B2 (en)
BR (1) BRPI0814267A2 (en)
CA (1) CA2693551C (en)
CL (1) CL2008002139A1 (en)
CO (1) CO6290692A2 (en)
CR (1) CR11225A (en)
CY (2) CY1112278T1 (en)
DK (2) DK2019104T3 (en)
DO (1) DOP2010000014A (en)
EA (1) EA019938B1 (en)
EC (1) ECSP109875A (en)
ES (2) ES2435779T3 (en)
GT (1) GT201000008A (en)
HK (1) HK1144289A1 (en)
HR (1) HRP20120067T1 (en)
IL (1) IL203318A (en)
JO (1) JO2744B1 (en)
MA (1) MA31617B1 (en)
ME (1) ME00969B (en)
MY (1) MY151245A (en)
NI (1) NI201000005A (en)
NZ (1) NZ582679A (en)
PA (1) PA8790201A1 (en)
PE (2) PE20090889A1 (en)
PL (2) PL2019104T3 (en)
PT (2) PT2019104E (en)
RS (1) RS52245B (en)
SI (2) SI2019104T1 (en)
TN (1) TN2010000002A1 (en)
TW (1) TWI500618B (en)
UA (1) UA98153C2 (en)
WO (1) WO2009016516A2 (en)
ZA (1) ZA201000389B (en)

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