CO6270323A2 - SOLID FORMS OF ACID (S) -2-AMINO-3- (4- (2-AMINO-6 - ((R) -2,2,2-TRIFLUORO- 1- (3'-METOXIBIFENIL-4-IL) ETOXI ) PIRIMIDIN-4-IL) PHENYL) PROPANOIC AND METHODS FOR USE - Google Patents

SOLID FORMS OF ACID (S) -2-AMINO-3- (4- (2-AMINO-6 - ((R) -2,2,2-TRIFLUORO- 1- (3'-METOXIBIFENIL-4-IL) ETOXI ) PIRIMIDIN-4-IL) PHENYL) PROPANOIC AND METHODS FOR USE

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Publication number
CO6270323A2
CO6270323A2 CO10054926A CO10054926A CO6270323A2 CO 6270323 A2 CO6270323 A2 CO 6270323A2 CO 10054926 A CO10054926 A CO 10054926A CO 10054926 A CO10054926 A CO 10054926A CO 6270323 A2 CO6270323 A2 CO 6270323A2
Authority
CO
Colombia
Prior art keywords
amino
trifluoro
phenyl
crystalline compound
acid
Prior art date
Application number
CO10054926A
Other languages
Spanish (es)
Inventor
Shinya Limura
Hui-Yin Li
Quiling Song
Wenxue Wu
Original Assignee
Lexicon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40344344&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6270323(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lexicon Pharmaceuticals Inc filed Critical Lexicon Pharmaceuticals Inc
Publication of CO6270323A2 publication Critical patent/CO6270323A2/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/34—Phthalazines with nitrogen atoms directly attached to carbon atoms of the nitrogen-containing ring, e.g. hydrazine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Se describen formas solidas de acido (S)-2-amino-3-(4-(2-amino-6-((R)-2,2,2-trifluoro-1-(3'-metoxibifenil-4-il)etoxi)pirimidin-4-iI)fenil)propanoico y sales del mismo.1.- Un compuesto cristalino, que es acido (S)2-amino-3-(4-(2-amino-6-((R)-2,2,2-trifluoro-1-(3'-metoxibifenil-4-il) etoxi)pirimidin-4-il)fenil)propanoico o una sal del mismo.2.- Un compuesto cristalino, que es tosilato de (S)-2- amino-3-(4-(2-amino-6-((R)-2,2,2-trifluoro-1-(3'-metoxibifenil-4-il)etoxi)pirimidin-4-il)fenil)propanoato.3.- El compuesto cristalino de la reivindicacion 2, que es anhidro.4.- El compuesto cristalino de la reivindicacion 3, que tiene un punto de fusion de aproximadamente 241°C.5.- El compuesto cristalino de la reivindicacion 3, que tiene un patron de difraccion de polvo de rayos x que comprende un pico en uno o mas de aproximadamente 3.5, 7.0, 8.6, 10.9, 13.5, 14.0, 15.1, 17.3 y/o 20.5 2? grados.6.- El compuesto de la reivindicacion 3, que tiene un patron de difraccion de polvo de rayos x sustancialmente el mismo como el que se muestra en la Figura 1.7.- El compuesto cristalino de la reivindicacion 2, que es un hidrato.8.- El compuesto cristalino de la reivindicacion 7, que es un monohidrato.Solid forms of (S) -2-amino-3- (4- (2-amino-6 - ((R) -2,2,2-trifluoro-1- (3'-methoxybiphenyl-4-yl) acid are described ) ethoxy) pyrimidin-4-iI) phenyl) propanoic acid and salts thereof.1.- A crystalline compound, which is (S) 2-amino-3- (4- (2-amino-6 - ((R) -2,2,2-trifluoro-1- (3'-methoxybiphenyl-4-yl) ethoxy) pyrimidin-4-yl) phenyl) propanoic acid or a salt thereof.2.- A crystalline compound, which is tosylate of ( S) -2- amino-3- (4- (2-amino-6 - ((R) -2,2,2-trifluoro-1- (3'-methoxybiphenyl-4-yl) ethoxy) pyrimidin-4- il) phenyl) propanoate. 3. The crystalline compound of claim 2, which is anhydrous. 4. The crystalline compound of claim 3, which has a melting point of approximately 241 ° C. 5. The crystalline compound. of claim 3, which has an x-ray powder diffraction pattern comprising a peak at one or more of approximately 3.5, 7.0, 8.6, 10.9, 13.5, 14.0, 15.1, 17.3 and / or 20.5 2? grades.6.- The compound of claim 3, which has an x-ray powder diffraction pattern substantially the same as that shown in Figure 1.7.- The crystalline compound of claim 2, which is a hydrate. 8. The crystalline compound of claim 7, which is a monohydrate.

CO10054926A 2007-10-08 2010-05-07 SOLID FORMS OF ACID (S) -2-AMINO-3- (4- (2-AMINO-6 - ((R) -2,2,2-TRIFLUORO- 1- (3'-METOXIBIFENIL-4-IL) ETOXI ) PIRIMIDIN-4-IL) PHENYL) PROPANOIC AND METHODS FOR USE CO6270323A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US97830307P 2007-10-08 2007-10-08

Publications (1)

Publication Number Publication Date
CO6270323A2 true CO6270323A2 (en) 2011-04-20

Family

ID=40344344

Family Applications (1)

Application Number Title Priority Date Filing Date
CO10054926A CO6270323A2 (en) 2007-10-08 2010-05-07 SOLID FORMS OF ACID (S) -2-AMINO-3- (4- (2-AMINO-6 - ((R) -2,2,2-TRIFLUORO- 1- (3'-METOXIBIFENIL-4-IL) ETOXI ) PIRIMIDIN-4-IL) PHENYL) PROPANOIC AND METHODS FOR USE

Country Status (20)

Country Link
US (1) US20090099206A1 (en)
EP (1) EP2231618A1 (en)
JP (1) JP2010540665A (en)
KR (1) KR20100066548A (en)
CN (1) CN101932563A (en)
AR (1) AR068837A1 (en)
AU (1) AU2008310979A1 (en)
BR (1) BRPI0818350A2 (en)
CA (1) CA2701904A1 (en)
CL (1) CL2008002980A1 (en)
CO (1) CO6270323A2 (en)
EA (1) EA201070455A1 (en)
EC (1) ECSP10010162A (en)
IL (1) IL204582A0 (en)
MX (1) MX2010003803A (en)
PE (1) PE20091213A1 (en)
TW (1) TW200932729A (en)
UY (1) UY31381A1 (en)
WO (1) WO2009048864A1 (en)
ZA (1) ZA201001870B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7897763B2 (en) 2005-12-29 2011-03-01 Lexicon Pharmaceuticals, Inc. Process for the preparation of substituted phenylalanines
EA019879B1 (en) * 2005-12-29 2014-07-30 Лексикон Фармасьютикалз, Инк. Multicyclic amino acid derivatives, pharmaceutical composition containing them and method of treatment using these derivatives
US7855291B2 (en) * 2005-12-29 2010-12-21 Lexicon Pharmaceuticals, Inc. Process for the preparation of substituted phenylalanines
MX2009013982A (en) * 2007-06-26 2010-04-09 Lexicon Pharmaceuticals Inc Compositions comprising tryptophan hydroxylase inhibitors.
TWI439457B (en) 2007-09-28 2014-06-01 Lexicon Pharmaceuticals Inc Solid forms of (s)-ethyl 2-amino-3-(4-(2-amino-6-((r)-1-(4-chloro-2-(3-methyl-1h-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)-pyrimidin-4-yl)phenyl)propanoate and methods of their use
AU2009231892A1 (en) * 2008-03-31 2009-10-08 The Trustees Of Columbia University In The City Of New York Methods of diagnosing, preventing and treating bone mass diseases
EP2504008A1 (en) * 2009-11-23 2012-10-03 Lexicon Pharmaceuticals, Inc. Methods and assays for the treatment of irritable bowel syndrome
WO2013148978A1 (en) * 2012-03-30 2013-10-03 Lexicon Pharmaceuticals, Inc. Methods and compositions for the treatment of necrotizing enterocolitis
KR20210102887A (en) * 2018-11-14 2021-08-20 알타반트 사이언시스 게엠베하 Crystalline spirocyclic compound inhibitors of tryptophan hydroxylase 1 (TPH1) for treating diseases or disorders associated with peripheral serotonin
WO2021238965A1 (en) * 2020-05-28 2021-12-02 杭州中美华东制药有限公司 Method for preparing methyl (s)-2-amino-3-(4-(2,3-dimethylpyridin-4-yl)phenylpropionate and salt thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7382793B1 (en) * 2002-01-17 2008-06-03 Juniper Networks, Inc. Systems and methods for determining the bandwidth used by a queue
US7897763B2 (en) * 2005-12-29 2011-03-01 Lexicon Pharmaceuticals, Inc. Process for the preparation of substituted phenylalanines
EA019879B1 (en) * 2005-12-29 2014-07-30 Лексикон Фармасьютикалз, Инк. Multicyclic amino acid derivatives, pharmaceutical composition containing them and method of treatment using these derivatives
US7855291B2 (en) * 2005-12-29 2010-12-21 Lexicon Pharmaceuticals, Inc. Process for the preparation of substituted phenylalanines
UA99270C2 (en) * 2006-12-12 2012-08-10 Лексикон Фармасьютикалз, Инк. 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use
WO2009002964A1 (en) * 2007-06-26 2008-12-31 Lexicon Pharmaceuticals, Inc. Methods of treating serotonin-mediated diseases and disorders
MX2009013982A (en) * 2007-06-26 2010-04-09 Lexicon Pharmaceuticals Inc Compositions comprising tryptophan hydroxylase inhibitors.
KR20100046189A (en) * 2007-07-11 2010-05-06 렉시컨 파마슈티컬스 인코퍼레이티드 Methods and compositions for treating pulmonary hypertension and related diseases and disorders
RU2010107066A (en) * 2007-07-26 2011-09-10 Лексикон Фармасьютикалз, Инк. (Us) METHODS OF INFLUENCE ON THE CONTENT OF THE CONTENT THROUGH THE GASTROINTESTINAL TRACT AND EMPTY OF THE STOMACH AND USED FOR THIS CONNECTION

Also Published As

Publication number Publication date
PE20091213A1 (en) 2009-08-26
CN101932563A (en) 2010-12-29
BRPI0818350A2 (en) 2017-10-10
TW200932729A (en) 2009-08-01
MX2010003803A (en) 2010-04-21
CA2701904A1 (en) 2009-04-16
CL2008002980A1 (en) 2009-03-20
ECSP10010162A (en) 2010-06-29
WO2009048864A1 (en) 2009-04-16
KR20100066548A (en) 2010-06-17
AR068837A1 (en) 2009-12-09
AU2008310979A1 (en) 2009-04-16
UY31381A1 (en) 2009-04-30
ZA201001870B (en) 2011-06-29
JP2010540665A (en) 2010-12-24
IL204582A0 (en) 2010-11-30
EA201070455A1 (en) 2010-08-30
US20090099206A1 (en) 2009-04-16
EP2231618A1 (en) 2010-09-29

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