CO6241154A2 - "NEW COMPOUNDS WITH AGONIST OR ANTAGONIST ACTION OF THE RECEIVER 1 VAINILLOIDE 1 (VR1 / TRPV1) \" - Google Patents

"NEW COMPOUNDS WITH AGONIST OR ANTAGONIST ACTION OF THE RECEIVER 1 VAINILLOIDE 1 (VR1 / TRPV1) \"

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Publication number
CO6241154A2
CO6241154A2 CO09118505A CO09118505A CO6241154A2 CO 6241154 A2 CO6241154 A2 CO 6241154A2 CO 09118505 A CO09118505 A CO 09118505A CO 09118505 A CO09118505 A CO 09118505A CO 6241154 A2 CO6241154 A2 CO 6241154A2
Authority
CO
Colombia
Prior art keywords
vainilloide
trpv1
agonist
receiver
new compounds
Prior art date
Application number
CO09118505A
Other languages
Spanish (es)
Inventor
Robert Frank
Gregor Bahrenberg
Thomas Christoph
Klaus Schiene
Vry Jean N De
Derek Saunders
Bernard Sundermann
Jeewoo Lee
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE102007018149A external-priority patent/DE102007018149A1/en
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of CO6241154A2 publication Critical patent/CO6241154A2/en

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    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

1.- Compuestos sustituidos de la fórmula general Ien la cual n indica 0, 1, 2, 3 ó 4; R1 y R2 juntos indican un residuo que se selecciona del grupo que consiste de -CH=N-NH-; -CH=N-NR71; -S-C(=S)-NH-; -O-C(=S)-NH-; -S-C(=O)-NH-; -O-C(=O)-NH-; -S-C(=S)-NR63-; -O-C(=S)-NR63-; -S-C(=O)-NR63-; -O-C(=O)-NR63-; -S-CH=N-; -S-CR29=N-; -N=CH-O-; -N=CR30-O-; -NH-C(=O)-NH-; -NH-C(=S)-NH-; -NR66-C(=O)-NR65-; -NR66-C(=S)-NR65; -O-CH2-C(=O)-NH-; -O-CH2-O-; -O-CH2-CH2-O-; -O-CH2-CH2-CH2-O-; y -O-CH2-CH2-NH- y -CH=CH-N=CH-, el cual está unido en cualquier dirección deseada a la estructura original, o R2 y R3 juntos indican un residuo que se selecciona del grupo que consiste de -CH=N-NH-; -CR28=N-NH-; -CH=N-NR62-; -CR28=N-NR62-; -S-C (=S) -NH-; -O-C (=S) -NH-; -S- C(=O)-NH-; -O-C(=O)-NH-; -S-C(=S) -NR63-; -O-C(=S) -NR63-; -S-C(=O)-NR63-; -O-C (=O)-NR63-; -S-CH=N-; -S-CR29=N-; -N=CH-O-; -N=CR30-O-; -N=CH-NH-; -N=CH-NR64-; -NH-C(=O)-NH-; -NH-C(=S)- -NH-; -NR66-C(=O)-NR65-; -NR66-C(=S)-NR65-; -N=N-NH-; -N=N-NR67; -O-CH2-C (=O) -NH-; -O-CH2-O-; -CH2-CH2-NH-; -CH2-CH2-CH2-NH-; -CH2-C (=O)-NH-, -CH2-CH2-C(=O) -NH-; -O-CH2-CH2-O-; -O-CH2-CH2-CH2-O-; -N=N-CH=CH-; -N=CH-N=CH; -N=CH-CH=N-; -CH=CH-CH=N-; -CH=CH-N=CH-; -CH=N-N=CH-, -N=N-CR68=CR69-; -N=CR68-N=CR69; -N=CR68-CR69=N-; -CR68=CR69-CH=N-; -CR68CR69- N=CR70; -CR68=N-N=CR69- y -O-CH2-CH2-NH-, el cual está unido en cualquier dirección deseada a la estructura de origen, o R3 y R4 juntos indican un residuo que se selecciona del grupo que consiste de -CH=N-NH-; -CR28N-NH-; -CH=N-NR62-; -CR28=N-NR62-; -S-C(=S)-NH-; -O-C(=S)-NH-; -S-C(=O)-NH-; -O-C(=O)-NH-; -O-C(=O)-NH-; -S-C(=S)-NR63-; -O-C(=S)-NR63-; -S-C(=O)-NR63-; -O-C(=O)-NR63-; -S-CH=N-; -S-CR29=N-; -N=CH-O-; -N=CR30-O-; -N=CH-NH-; -N=CH-NR64-; -NH-C(=O)-NH-; -NH-C(=S)-NH-; -NR66-C(=O)-NR65-; ...1.- Substituted compounds of the general formula I in which n indicates 0, 1, 2, 3 or 4; R1 and R2 together indicate a residue that is selected from the group consisting of -CH = N-NH-; -CH = N-NR71; -S-C (= S) -NH-; -O-C (= S) -NH-; -S-C (= O) -NH-; -O-C (= O) -NH-; -S-C (= S) -NR63-; -O-C (= S) -NR63-; -S-C (= O) -NR63-; -O-C (= O) -NR63-; -S-CH = N-; -S-CR29 = N-; -N = CH-O-; -N = CR30-O-; -NH-C (= O) -NH-; -NH-C (= S) -NH-; -NR66-C (= O) -NR65-; -NR66-C (= S) -NR65; -O-CH2-C (= O) -NH-; -O-CH2-O-; -O-CH2-CH2-O-; -O-CH2-CH2-CH2-O-; and -O-CH2-CH2-NH- and -CH = CH-N = CH-, which is attached in any desired direction to the original structure, or R2 and R3 together indicate a residue that is selected from the group consisting of -CH = N-NH-; -CR28 = N-NH-; -CH = N-NR62-; -CR28 = N-NR62-; -S-C (= S) -NH-; -O-C (= S) -NH-; -S- C (= O) -NH-; -O-C (= O) -NH-; -S-C (= S) -NR63-; -O-C (= S) -NR63-; -S-C (= O) -NR63-; -O-C (= O) -NR63-; -S-CH = N-; -S-CR29 = N-; -N = CH-O-; -N = CR30-O-; -N = CH-NH-; -N = CH-NR64-; -NH-C (= O) -NH-; -NH-C (= S) - -NH-; -NR66-C (= O) -NR65-; -NR66-C (= S) -NR65-; -N = N-NH-; -N = N-NR67; -O-CH2-C (= O) -NH-; -O-CH2-O-; -CH2-CH2-NH-; -CH2-CH2-CH2-NH-; -CH2-C (= O) -NH-, -CH2-CH2-C (= O) -NH-; -O-CH2-CH2-O-; -O-CH2-CH2-CH2-O-; -N = N-CH = CH-; -N = CH-N = CH; -N = CH-CH = N-; -CH = CH-CH = N-; -CH = CH-N = CH-; -CH = N-N = CH-, -N = N-CR68 = CR69-; -N = CR68-N = CR69; -N = CR68-CR69 = N-; -CR68 = CR69-CH = N-; -CR68CR69- N = CR70; -CR68 = NN = CR69- and -O-CH2-CH2-NH-, which is attached in any desired direction to the source structure, or R3 and R4 together indicate a residue that is selected from the group consisting of -CH = N-NH-; -CR28N-NH-; -CH = N-NR62-; -CR28 = N-NR62-; -S-C (= S) -NH-; -O-C (= S) -NH-; -S-C (= O) -NH-; -O-C (= O) -NH-; -O-C (= O) -NH-; -S-C (= S) -NR63-; -O-C (= S) -NR63-; -S-C (= O) -NR63-; -O-C (= O) -NR63-; -S-CH = N-; -S-CR29 = N-; -N = CH-O-; -N = CR30-O-; -N = CH-NH-; -N = CH-NR64-; -NH-C (= O) -NH-; -NH-C (= S) -NH-; -NR66-C (= O) -NR65-; ...

CO09118505A 2007-04-16 2009-10-22 "NEW COMPOUNDS WITH AGONIST OR ANTAGONIST ACTION OF THE RECEIVER 1 VAINILLOIDE 1 (VR1 / TRPV1) \" CO6241154A2 (en)

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