CO5690639A2 - ACICLIC PIRAZOL COMPOUNDS FOR THE INHIBITION OF PROTEIN KINASE-2 ACTIVATED BY PROTEIN KINASE ACTIVATED BY MYTHOGENS - Google Patents
ACICLIC PIRAZOL COMPOUNDS FOR THE INHIBITION OF PROTEIN KINASE-2 ACTIVATED BY PROTEIN KINASE ACTIVATED BY MYTHOGENSInfo
- Publication number
- CO5690639A2 CO5690639A2 CO05058718A CO05058718A CO5690639A2 CO 5690639 A2 CO5690639 A2 CO 5690639A2 CO 05058718 A CO05058718 A CO 05058718A CO 05058718 A CO05058718 A CO 05058718A CO 5690639 A2 CO5690639 A2 CO 5690639A2
- Authority
- CO
- Colombia
- Prior art keywords
- activated
- carbon
- protein kinase
- nitrogen
- mythogens
- Prior art date
Links
Landscapes
- Enzymes And Modification Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1.- Un compuesto que tiene la estructura en donde:Z2 y Z3 son nitrógeno, Z1, Z4 y Z5 son carbono, y se juntan con Z2 y Z3 para formar un anillo pirazol, o de manera opcional, Z4 y Z5 son nitrógeno, Z1, Z2 y Z3 son carbono y se juntan con Z4 y Z5 para formar un anillo pirazol;Ra se selecciona de: donde las líneas discontinuas indican enlaces simples o dobles opcionales;cuando Ra es anillo M y anillo M es aromático, M1 es carbono y es sustituido con (L)nR1, M5 es carbono, y cada uno de M2, M3, M4 y M6 se selecciona independientemente de carbono y nitrógeno y es no sustituido o sustituido con (L)nR1;cuando anillo M es parcialmente saturado, M1 es carbono y es mono- o di-sustituido con (L)nR1, M5 es carbono, y cada uno de M2, M3, M4 y M6 se selecciona independientemente de carbono, nitrógeno, oxígeno y azufre, y cuando M2, M3, M4, o M6 es oxígeno o azufre, es no sustituido, y cuando M2, M3, M4 o M6 es carbono o nitrógeno, es opcionalmente no sustituido; o mono- o di-sustituido con (L)nR1; ...1.- A compound that has the structure where: Z2 and Z3 are nitrogen, Z1, Z4 and Z5 are carbon, and join with Z2 and Z3 to form a pyrazole ring, or optionally, Z4 and Z5 are nitrogen, Z1, Z2 and Z3 are carbon and join with Z4 and Z5 to form a pyrazole ring; Ra is selected from: where dashed lines indicate optional single or double bonds; when Ra is ring M and ring M is aromatic, M1 is carbon and is substituted with (L) nR1, M5 is carbon, and each of M2, M3, M4 and M6 is independently selected from carbon and nitrogen and is unsubstituted or substituted with (L) nR1; when ring M is partially saturated, M1 is carbon and is mono- or di-substituted with (L) nR1, M5 is carbon, and each of M2, M3, M4 and M6 is independently selected from carbon, nitrogen, oxygen and sulfur, and when M2, M3, M4, or M6 is oxygen or sulfur, is unsubstituted, and when M2, M3, M4 or M6 is carbon or nitrogen, it is optionally unsubstituted; or mono- or di-substituted with (L) nR1; ...
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43496200P | 2000-12-20 | 2000-12-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5690639A2 true CO5690639A2 (en) | 2006-10-31 |
Family
ID=42138717
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO05058718A CO5690639A2 (en) | 2000-12-20 | 2005-06-16 | ACICLIC PIRAZOL COMPOUNDS FOR THE INHIBITION OF PROTEIN KINASE-2 ACTIVATED BY PROTEIN KINASE ACTIVATED BY MYTHOGENS |
Country Status (1)
| Country | Link |
|---|---|
| CO (1) | CO5690639A2 (en) |
-
2005
- 2005-06-16 CO CO05058718A patent/CO5690639A2/en unknown
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