CO5261620A1 - CARBAPENEM COMPOUNDS, USE OF THE SAME AND INTERMEDIATE COMPOUNDS FOR THE SAME - Google Patents

CARBAPENEM COMPOUNDS, USE OF THE SAME AND INTERMEDIATE COMPOUNDS FOR THE SAME

Info

Publication number
CO5261620A1
CO5261620A1 CO00091283A CO00091283A CO5261620A1 CO 5261620 A1 CO5261620 A1 CO 5261620A1 CO 00091283 A CO00091283 A CO 00091283A CO 00091283 A CO00091283 A CO 00091283A CO 5261620 A1 CO5261620 A1 CO 5261620A1
Authority
CO
Colombia
Prior art keywords
same
compounds
formula
optionally substituted
lower alkyl
Prior art date
Application number
CO00091283A
Other languages
Spanish (es)
Inventor
Hiroshi Matsui
Original Assignee
Kyoto Pharma Ind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyoto Pharma Ind filed Critical Kyoto Pharma Ind
Publication of CO5261620A1 publication Critical patent/CO5261620A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Abstract

Un compuesto de carbapenem de la fórmula (I)<EMI FILE="00091283_1" ID="1" IMF=JPEG >en donde R1 es un grupo acilo de un a-aminoácido en donde el amino está opcionalmente sustituido por alquilo inferior, R2 es un átomo de hidrógeno o un alquilo inferior, R3 es un fenilo opcionalmente sustituido, o una sal del mismo farmacéuticamente aceptable. Un agente antibacteriano que comprende el compuesto de carbapenem de la reivindicación 1, el cual es representado por la fórmula (I), o una sal farmacéuticamente aceptable del mismo como ingrediente activo. Un compuesto de carbapenem de la fórmula (ll)<EMI FILE="00091283_2" ID="2" IMF=JPEG >en donde R2 es un átomo de hidrógeno u un alquilo inferior, yR3 es un fenilo opcionalmente sustituido, o una sal del mismo.A carbapenem compound of the formula (I) <EMI FILE = "00091283_1" ID = "1" IMF = JPEG> wherein R1 is an acyl group of an amino acid wherein the amino is optionally substituted by lower alkyl, R2 it is a hydrogen atom or a lower alkyl, R3 is an optionally substituted phenyl, or a pharmaceutically acceptable salt thereof. An antibacterial agent comprising the carbapenem compound of claim 1, which is represented by formula (I), or a pharmaceutically acceptable salt thereof as an active ingredient. A carbapenem compound of the formula (ll) <EMI FILE = "00091283_2" ID = "2" IMF = JPEG> wherein R2 is a hydrogen atom or a lower alkyl, and R3 is an optionally substituted phenyl, or a salt of the same.

CO00091283A 1999-12-03 2000-11-29 CARBAPENEM COMPOUNDS, USE OF THE SAME AND INTERMEDIATE COMPOUNDS FOR THE SAME CO5261620A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP34553599 1999-12-03

Publications (1)

Publication Number Publication Date
CO5261620A1 true CO5261620A1 (en) 2003-03-31

Family

ID=18377257

Family Applications (1)

Application Number Title Priority Date Filing Date
CO00091283A CO5261620A1 (en) 1999-12-03 2000-11-29 CARBAPENEM COMPOUNDS, USE OF THE SAME AND INTERMEDIATE COMPOUNDS FOR THE SAME

Country Status (4)

Country Link
AR (1) AR026682A1 (en)
AU (1) AU1419501A (en)
CO (1) CO5261620A1 (en)
WO (1) WO2001040228A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114716487B (en) * 2022-02-24 2024-03-08 四川农业大学 Furanodiester compound and preparation method and application thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3965099A (en) * 1974-06-26 1976-06-22 Smithkline Corporation Cephalosporin esters with antibacterial activity
US4503040A (en) * 1984-02-27 1985-03-05 Pfizer Inc. 6-(Aminoacyloxymethyl)penicillanic acid 1,1-dioxides as beta-lactamase inhibitors
JP2847693B2 (en) * 1992-06-18 1999-01-20 田辺製薬株式会社 Removal method of carboxyl group protecting group
JPH06298769A (en) * 1993-04-13 1994-10-25 Fujisawa Pharmaceut Co Ltd Ampicillin phenyl ester and its salt
JP2000239275A (en) * 1998-12-25 2000-09-05 Sankyo Co Ltd Carbapenem ester derivative

Also Published As

Publication number Publication date
AU1419501A (en) 2001-06-12
AR026682A1 (en) 2003-02-19
WO2001040228A1 (en) 2001-06-07

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Legal Events

Date Code Title Description
FC Application refused