CO5170526A1 - NEW USEFUL CYCLING GUANIDINE COMPOUNDS AS ANTAGONIS TAS OF THE IL-8 RECEIVER - Google Patents
NEW USEFUL CYCLING GUANIDINE COMPOUNDS AS ANTAGONIS TAS OF THE IL-8 RECEIVERInfo
- Publication number
- CO5170526A1 CO5170526A1 CO00038194A CO00038194A CO5170526A1 CO 5170526 A1 CO5170526 A1 CO 5170526A1 CO 00038194 A CO00038194 A CO 00038194A CO 00038194 A CO00038194 A CO 00038194A CO 5170526 A1 CO5170526 A1 CO 5170526A1
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- cr8r8
- alkenyl
- optionally substituted
- heteroaryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Un compuesto de la fórmula (I).<EMI FILE="00038194_1" ID="1" IMF=JPEG >donde:R es OH, SH, NHSO2Rd; Rd es NR6R7, alquilo, aril-alquilo C1-4, aril-alquenilo C2-4, heteroarilo, heteroaril-alquilo C1-4, heteroaril-alquenilo C2-4, radical heterocíclico, heterociclil-alquilo C1-4, donde los anillos arilo, heteoarilo y heterocíclico pueden estar opcionalmente sustituidos;R6 y R7 son, independientemente, hidrógeno, o un grupo alquilo C1-4, o R6 y R7, junto con el nitrógeno al que están unidos, forman un anillo de 5 a 7 miembros, cuyo anillo puede contener opcionalmente un heteroátomo adicional que se selecciona entre oxígeno, nitrógeno o azufre, y cuyo anillo puede estar opcionalmente sustituido; R1 se selecciona, independientemente, entre hidrógeno, halógeno, nitro, ciano, alquilo C1-10 halosustituido, alquilo C1-10, alquenilo C2-10, alcoxi C1-10, alcoxi C1-10 halosustituido, azida, (CR8R8)qS(O)tR4, hidroxi, hidroxi-alquilo C1-4, arilo, aril-alquilo C1-4, ariloxi, aril-alquiloxi C1-4, heteroarilo, heteroarilalquilo, radical heterocíclico, heterociclil-alquilo C1-4, heteroaril-alquiloxi C1-4, aril-alquenilo C2-10, heteroaril-alquenilo C2-10, heterociclil- alquenilo C2-10, (CR8R8)qNR4R5, alquenil C2-10-C(O)NR4R5, (CR8R8)qC(O)NR4R5, (CR8R8)qC(O)NR4R10, S(O)3H, S(O)3R8, (CR8R8)qC(O)R11, alquenil C2-10-C(O)R11, alquenil C2-10-C(O)OR11, (CR8R8)qC(O)OR12, (CR8R8)qOC(O)R11, (CR8R8)qNR4C(O)R11, (CR8R8)qNHS(O)2R17, (CR8R8)qS(O)2NR4R5, o dos restos R1 juntos pueden formar O-(CH2)sO- o un anillo insaturado de 5 a 6 miembros; R2 es C(O), S(O), S(O)2, o C(NH); q es 0, o un número entero que tiene un valor de 1 a 10; t es 0, o un número entero que tiene un valor de 1 ó 2; s es un número entero que tiene un valor de 1 a 3; R4 y R5 son, independientemente, hidrógeno, alquilo C1-4 opcionalmente sustituido, arilo opcionalmente sustituido, (aril opcionalmente sustituido)-alquilo C1-4, heteroarilo opcionalmente sustituido, (heteroaril opcionalmente sustituido)-alquilo C1-4, radical heterocíclico, heterociclil-alquilo C1-4, o R4 y R5, junto con el nitrógeno al que están unidos, forman un anillo de 5 a 7 miembros que puede contener opcionalmente un heteroátomo adicional seleccionado entre oxígeno, nitrógeno o azufre; ...A compound of the formula (I). <EMI FILE = "00038194_1" ID = "1" MFI = JPEG> where: R is OH, SH, NHSO2Rd; Rd is NR6R7, alkyl, arylC 1-4 alkyl, arylC2-4 alkenyl, heteroaryl, heteroarylC 1-4 alkyl, heteroarylC2-4 alkenyl, heterocyclic radical, heterocyclylC 1-4 alkyl, where the aryl rings , heteroaryl and heterocyclic may be optionally substituted; R6 and R7 are, independently, hydrogen, or a C1-4 alkyl group, or R6 and R7, together with the nitrogen to which they are attached, form a 5- to 7-membered ring, whose ring may optionally contain an additional heteroatom that is selected from oxygen, nitrogen or sulfur, and whose ring may be optionally substituted; R1 is independently selected from hydrogen, halogen, nitro, cyano, halosubstituted C1-10 alkyl, C1-10 alkyl, C2-10 alkenyl, C1-10 alkoxy, halosubstituted C1-10 alkoxy, azide, (CR8R8) qS (O ) tR4, hydroxy, hydroxyC 1-4 alkyl, aryl, arylC 1-4 alkyl, aryloxy, arylC 1-4 alkyloxy, heteroaryl, heteroarylalkyl, heterocyclic radical, heterocyclylC 1-4 alkyl, heteroarylC 1-4 alkyloxy , C2-10 aryl-alkenyl, C2-10 heteroaryl-alkenyl, C2-10 heterocyclyl-alkenyl, (CR8R8) qNR4R5, C2-10-C alkenyl (O) NR4R5, (CR8R8) qC (O) NR4R5, (CR8R8) qC (O) NR4R10, S (O) 3H, S (O) 3R8, (CR8R8) qC (O) R11, C2-10-C alkenyl (O) R11, C2-10-C alkenyl (O) OR11, ( CR8R8) qC (O) OR12, (CR8R8) qOC (O) R11, (CR8R8) qNR4C (O) R11, (CR8R8) qNHS (O) 2R17, (CR8R8) qS (O) 2NR4R5, or two R1 moieties together can forming O- (CH2) sO- or an unsaturated ring of 5 to 6 members; R2 is C (O), S (O), S (O) 2, or C (NH); q is 0, or an integer that has a value from 1 to 10; t is 0, or an integer that has a value of 1 or 2; s is an integer that has a value of 1 to 3; R4 and R5 are, independently, hydrogen, optionally substituted C1-4 alkyl, optionally substituted aryl, (optionally substituted aryl) -C1-4 alkyl, optionally substituted heteroaryl, (optionally substituted heteroaryl) -C 1-4 alkyl, heterocyclic radical, heterocyclyl - C1-4 alkyl, or R4 and R5, together with the nitrogen to which they are attached, form a 5 to 7 member ring that may optionally contain an additional heteroatom selected from oxygen, nitrogen or sulfur; ...
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13666799P | 1999-05-28 | 1999-05-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5170526A1 true CO5170526A1 (en) | 2002-06-27 |
Family
ID=22473837
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO00038194A CO5170526A1 (en) | 1999-05-28 | 2000-05-24 | NEW USEFUL CYCLING GUANIDINE COMPOUNDS AS ANTAGONIS TAS OF THE IL-8 RECEIVER |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU5168900A (en) |
| CO (1) | CO5170526A1 (en) |
| WO (1) | WO2000073282A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2456868A1 (en) * | 2001-08-13 | 2003-02-27 | Henning Boettcher | Inhibitors of polyq-aggregation |
| CN103467390B (en) * | 2013-09-26 | 2015-04-22 | 苏州大学 | Method for preparing 2-amino-4(3H)-quinazolinones |
| CN105853434A (en) * | 2016-04-13 | 2016-08-17 | 李春 | Medicinal composition for treating gingivitis in orthodontic children |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994026722A1 (en) * | 1993-05-12 | 1994-11-24 | E.I. Du Pont De Nemours And Company | Fungicidal fused bicyclic pyrimidinones |
| EP0836602B1 (en) * | 1995-07-05 | 2002-01-30 | E.I. Du Pont De Nemours And Company | Fungicidal pyrimidinones |
-
2000
- 2000-05-24 CO CO00038194A patent/CO5170526A1/en not_active Application Discontinuation
- 2000-05-26 WO PCT/US2000/014659 patent/WO2000073282A1/en active Application Filing
- 2000-05-26 AU AU51689/00A patent/AU5168900A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU5168900A (en) | 2000-12-18 |
| WO2000073282A1 (en) | 2000-12-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Application withdrawn |