CO5170461A1 - DERIVATIVES OF 1,5-BENZODIAZEPIN MIND, PHARMACEUTICAL COMPOSITION CONTAINING IT, PROCESS FOR ITS PREPARATION AND IMPROVED PROCESS FOR THE PREPARATION OF INTERMEDIARIES FOR THE DERIVED SISNTHESIS - Google Patents
DERIVATIVES OF 1,5-BENZODIAZEPIN MIND, PHARMACEUTICAL COMPOSITION CONTAINING IT, PROCESS FOR ITS PREPARATION AND IMPROVED PROCESS FOR THE PREPARATION OF INTERMEDIARIES FOR THE DERIVED SISNTHESISInfo
- Publication number
- CO5170461A1 CO5170461A1 CO00031982A CO00031982A CO5170461A1 CO 5170461 A1 CO5170461 A1 CO 5170461A1 CO 00031982 A CO00031982 A CO 00031982A CO 00031982 A CO00031982 A CO 00031982A CO 5170461 A1 CO5170461 A1 CO 5170461A1
- Authority
- CO
- Colombia
- Prior art keywords
- preparation
- phenyl
- formula
- mfi
- jpeg
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
El compuesto caracterizado porque es el ácido 3-{3-[1-(lsopropil-fenil-carbamoilmetil)-2,4-dioxo-5-fenil-2,3,4,5-tetrahidro-1H-benzo[b][1,4]diazepin-3-il]ureido}benzoico enantioméricamente enriquecido, o una sal o solvato farmacéuticamente aceptable del mismo.<EMI FILE="00031982_1" ID="1" IMF=JPEG >Un proceso para la preparación de un compuesto de conformidad con la reivindicación 1, caracterizado porque comprende:(a) la separación del 3-[3-[1-(lsopropil-fenil-carbamoilmetil)-2,4-dioxo-5-fenil-2,3,4,5-tetrahidro-1H-benzo[b][1,4] diazepin-3-il]benzoico racémico, por cromatografía de líquidos de alta resolución, quiral;(b) la reacción del enantiómero apropiado de la amina de fórmula (II),<EMI FILE="00031982_2" ID="2" IMF=JPEG >Con el isocianato de fórmula (III), imidazolida de fórmula (IV) o carbamato de fenilo opcionalmente substituido de fórmula (V), seguido de la eliminación del grupo protector carboxi, R.<EMI FILE="00031982_3" ID="3" IMF=JPEG >The compound characterized in that it is 3- {3- [1- (lsopropyl-phenyl-carbamoylmethyl) -2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo [b] [ 1,4] diazepin-3-yl] ureido} enantiomerically enriched benzoic, or a pharmaceutically acceptable salt or solvate thereof. <EMI FILE = "00031982_1" ID = "1" MFI = JPEG> A process for the preparation of a compound according to claim 1, characterized in that it comprises: (a) the separation of 3- [3- [1- (lsopropyl-phenyl-carbamoylmethyl) -2,4-dioxo-5-phenyl-2,3,4,5 racemic -trahydro-1H-benzo [b] [1,4] diazepin-3-yl] benzoic, by high performance liquid chromatography, chiral; (b) the reaction of the appropriate enantiomer of the amine of formula (II), <EMI FILE = "00031982_2" ID = "2" MFI = JPEG> With the isocyanate of formula (III), imidazolide of formula (IV) or optionally substituted phenyl carbamate of formula (V), followed by removal of the protective group carboxy, R. <EMI FILE = "00031982_3" ID = "3" MFI = JPEG>
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9910366.5A GB9910366D0 (en) | 1999-05-06 | 1999-05-06 | 1,5-Benzodiazepine Derivatives |
| GBGB0008179.4A GB0008179D0 (en) | 2000-04-05 | 2000-04-05 | Chemical process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5170461A1 true CO5170461A1 (en) | 2002-06-27 |
Family
ID=26244033
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO00031982A CO5170461A1 (en) | 1999-05-06 | 2000-05-04 | DERIVATIVES OF 1,5-BENZODIAZEPIN MIND, PHARMACEUTICAL COMPOSITION CONTAINING IT, PROCESS FOR ITS PREPARATION AND IMPROVED PROCESS FOR THE PREPARATION OF INTERMEDIARIES FOR THE DERIVED SISNTHESIS |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP1212305A2 (en) |
| JP (1) | JP2002544200A (en) |
| KR (1) | KR20020012567A (en) |
| CN (1) | CN1161345C (en) |
| AR (1) | AR022044A1 (en) |
| AU (1) | AU4754800A (en) |
| BR (1) | BR0010338A (en) |
| CA (1) | CA2370801A1 (en) |
| CO (1) | CO5170461A1 (en) |
| CZ (1) | CZ20013988A3 (en) |
| HK (1) | HK1046138A1 (en) |
| HU (1) | HUP0201181A3 (en) |
| IL (1) | IL146124A0 (en) |
| MX (1) | MXPA01011267A (en) |
| MY (1) | MY138319A (en) |
| NO (1) | NO20015397L (en) |
| NZ (1) | NZ515048A (en) |
| PE (1) | PE20010110A1 (en) |
| PL (1) | PL351546A1 (en) |
| TR (1) | TR200103169T2 (en) |
| WO (1) | WO2000068209A2 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005035793A2 (en) * | 2003-10-09 | 2005-04-21 | Decode Genetics Ehf. | Cckar markers and haplotypes associated with extreme weight conditions |
| JP4069159B2 (en) | 2004-05-25 | 2008-04-02 | ファイザー・プロダクツ・インク | Tetraazabenzo [e] azulene derivatives and analogs thereof |
| KR20220150270A (en) | 2019-10-07 | 2022-11-10 | 칼리오페, 인크. | GPR119 agonists |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9307833D0 (en) * | 1993-04-15 | 1993-06-02 | Glaxo Inc | Modulators of cholecystokinin and gastrin |
-
2000
- 2000-05-03 AR ARP000102119A patent/AR022044A1/en unknown
- 2000-05-04 WO PCT/EP2000/003982 patent/WO2000068209A2/en not_active Application Discontinuation
- 2000-05-04 HU HU0201181A patent/HUP0201181A3/en unknown
- 2000-05-04 EP EP00929488A patent/EP1212305A2/en not_active Withdrawn
- 2000-05-04 PL PL00351546A patent/PL351546A1/en not_active Application Discontinuation
- 2000-05-04 AU AU47548/00A patent/AU4754800A/en not_active Abandoned
- 2000-05-04 IL IL14612400A patent/IL146124A0/en unknown
- 2000-05-04 MY MYPI20001917A patent/MY138319A/en unknown
- 2000-05-04 NZ NZ515048A patent/NZ515048A/en unknown
- 2000-05-04 CN CNB008099324A patent/CN1161345C/en not_active Expired - Fee Related
- 2000-05-04 MX MXPA01011267A patent/MXPA01011267A/en not_active Application Discontinuation
- 2000-05-04 KR KR1020017014075A patent/KR20020012567A/en not_active Application Discontinuation
- 2000-05-04 CO CO00031982A patent/CO5170461A1/en not_active Application Discontinuation
- 2000-05-04 CZ CZ20013988A patent/CZ20013988A3/en unknown
- 2000-05-04 JP JP2000617189A patent/JP2002544200A/en active Pending
- 2000-05-04 PE PE2000000415A patent/PE20010110A1/en not_active Application Discontinuation
- 2000-05-04 BR BR0010338-1A patent/BR0010338A/en not_active IP Right Cessation
- 2000-05-04 CA CA002370801A patent/CA2370801A1/en not_active Abandoned
- 2000-05-04 TR TR2001/03169T patent/TR200103169T2/en unknown
-
2001
- 2001-11-05 NO NO20015397A patent/NO20015397L/en not_active Application Discontinuation
-
2002
- 2002-10-23 HK HK02107684.4A patent/HK1046138A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ515048A (en) | 2004-01-30 |
| TR200103169T2 (en) | 2002-04-22 |
| AU4754800A (en) | 2000-11-21 |
| CN1161345C (en) | 2004-08-11 |
| IL146124A0 (en) | 2002-07-25 |
| NO20015397D0 (en) | 2001-11-05 |
| WO2000068209A2 (en) | 2000-11-16 |
| KR20020012567A (en) | 2002-02-16 |
| MY138319A (en) | 2009-05-29 |
| CN1362949A (en) | 2002-08-07 |
| EP1212305A2 (en) | 2002-06-12 |
| MXPA01011267A (en) | 2002-05-06 |
| JP2002544200A (en) | 2002-12-24 |
| HUP0201181A3 (en) | 2003-10-28 |
| BR0010338A (en) | 2002-02-13 |
| CA2370801A1 (en) | 2000-11-16 |
| PL351546A1 (en) | 2003-05-05 |
| CZ20013988A3 (en) | 2002-02-13 |
| NO20015397L (en) | 2001-11-05 |
| HK1046138A1 (en) | 2002-12-27 |
| PE20010110A1 (en) | 2001-03-05 |
| AR022044A1 (en) | 2002-09-04 |
| WO2000068209A3 (en) | 2001-03-01 |
| HUP0201181A2 (en) | 2002-12-28 |
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| Date | Code | Title | Description |
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| FC | Application refused |