CO5160245A1 - ORGANIC COMPOUNDS INHIBITORS OF CYSTEINE PROTEINS, IN PARTICULAR INHIBITORS OF CATEPSIN K OF ARILAMINOALQUILAMIDA, AND ITS PHARMACEUTICAL USE FOR THE TREATMENT OR PROFILAXIS OF DISEASES OR MEDICAL CONDITIONS WHERE THIS IMPLICATES - Google Patents

ORGANIC COMPOUNDS INHIBITORS OF CYSTEINE PROTEINS, IN PARTICULAR INHIBITORS OF CATEPSIN K OF ARILAMINOALQUILAMIDA, AND ITS PHARMACEUTICAL USE FOR THE TREATMENT OR PROFILAXIS OF DISEASES OR MEDICAL CONDITIONS WHERE THIS IMPLICATES

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Publication number
CO5160245A1
CO5160245A1 CO00004735A CO00004735A CO5160245A1 CO 5160245 A1 CO5160245 A1 CO 5160245A1 CO 00004735 A CO00004735 A CO 00004735A CO 00004735 A CO00004735 A CO 00004735A CO 5160245 A1 CO5160245 A1 CO 5160245A1
Authority
CO
Colombia
Prior art keywords
inhibitors
arilaminoalquilamida
profilaxis
catepsin
implicates
Prior art date
Application number
CO00004735A
Other languages
Spanish (es)
Inventor
Eva Altmann
Rene Lattmann
Martin Missbach
Johanne Renaud
Original Assignee
Novartis Ag
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Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CO5160245A1 publication Critical patent/CO5160245A1/en

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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
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    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
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    • C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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Abstract

La presente invención se relaciona con una aminoácido-arilaminoalquilamida, en donde el grupo carboxilo C-terminal del aminoácido está sustituido por un sustituyente de arilaminoalquilamino, y en donde el átomo de nitrógeno del amino del aminoácido forma un enlace de péptido o de seudopéptido que opcionalmente comprende en adición un enlazador de -metileno-heteroátomo-, o un heteroátomo adicional, a través del cual está directamente sustituido por arilo, alquilo inferior, alquenilo inferior, alquinilo inferior, o heterociclilo, en donde el término inferior define un compuesto ó un radical el cual puede ser ramificado ó no ramificado con hasta e incluyendo 7 átomos de carbono, ó un éster fisiológicamente aceptable y disociable, o una sal de la misma.The present invention relates to an amino acid-arylaminoalkylamide, wherein the C-terminal carboxyl group of the amino acid is substituted by an arylaminoalkylamino substituent, and wherein the amino acid nitrogen atom forms a peptide or pseudopeptide bond which optionally it further comprises a -methylene-heteroatom- linker, or an additional heteroatom, through which it is directly substituted by aryl, lower alkyl, lower alkenyl, lower alkynyl, or heterocyclyl, wherein the lower term defines a compound or a radical which can be branched or unbranched with up to and including 7 carbon atoms, or a physiologically acceptable and dissociable ester, or a salt thereof.

CO00004735A 1999-02-16 2000-01-27 ORGANIC COMPOUNDS INHIBITORS OF CYSTEINE PROTEINS, IN PARTICULAR INHIBITORS OF CATEPSIN K OF ARILAMINOALQUILAMIDA, AND ITS PHARMACEUTICAL USE FOR THE TREATMENT OR PROFILAXIS OF DISEASES OR MEDICAL CONDITIONS WHERE THIS IMPLICATES CO5160245A1 (en)

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WO2002070517A2 (en) * 2001-03-02 2002-09-12 Merck Frosst Canada & Co. Cathepsin cysteine protease inhibitors
US6982263B2 (en) 2001-06-08 2006-01-03 Boehringer Ingelheim Pharmaceuticals, Inc. Nitriles useful as reversible inhibitors of cysteine proteases
US6900237B2 (en) 2001-09-14 2005-05-31 Axys Pharmaceuticals, Inc. Sulfonamide compounds as protease inhibitors
KR100962972B1 (en) * 2002-07-26 2010-06-09 주식회사유한양행 1-phenylpiperidin-3-one derivatives and processes for the preparation thereof
US7109243B2 (en) * 2003-03-24 2006-09-19 Irm Llc Inhibitors of cathepsin S
US7384970B2 (en) 2003-03-24 2008-06-10 Irm Llc Inhibitors of cathepsin S
US7173051B2 (en) 2003-06-13 2007-02-06 Irm, Llc Inhibitors of cathepsin S
US7256207B2 (en) 2003-08-20 2007-08-14 Irm Llc Inhibitors of cathepsin S
AU2011265309B2 (en) * 2003-11-21 2014-06-05 Array Biopharma, Inc. AKT protein kinase inhibitors
RU2006121990A (en) 2003-11-21 2007-12-27 Эррэй Биофарма Инк. (Us) ACT PROTEINKINASE INHIBITORS
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