CO5050329A1 - NEW DERIVATIVES OF TETRAHYDROISOQUINOLEINE AND PROCEDURES FOR THEIR PREPARATION - Google Patents

NEW DERIVATIVES OF TETRAHYDROISOQUINOLEINE AND PROCEDURES FOR THEIR PREPARATION

Info

Publication number
CO5050329A1
CO5050329A1 CO98023497A CO98023497A CO5050329A1 CO 5050329 A1 CO5050329 A1 CO 5050329A1 CO 98023497 A CO98023497 A CO 98023497A CO 98023497 A CO98023497 A CO 98023497A CO 5050329 A1 CO5050329 A1 CO 5050329A1
Authority
CO
Colombia
Prior art keywords
alkyl
group
alkoxy
optionally substituted
ring
Prior art date
Application number
CO98023497A
Other languages
Spanish (es)
Inventor
Branch Clive Leslie
Christopher Norbert Johnson
Geoffrey Stemp
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of CO5050329A1 publication Critical patent/CO5050329A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Un compuesto de fórmula (I): en la cual: R1 representa un sustituyente seleccionado de: un átomo de hidrógeno o de halógeno; un grupo hidroxi, ciano, nitro, trifluorometilo, trifluorometoxi, trifluorometanosulfoniloxi, pertafluoroetilo, alquilo C1-4 , alcoxi C1-4 , aril-alcoxi C1-4 , alquiltio C1-4 , alcoxi C1-4 -alquilo C1-4 , cicloalquil C3-6 - alcoxi C1-4 , alcanoílo C1-4 , alcoxi C1-4 - carbonilo, alquilsulfonilo C1-4 , alquilsulfoniloxi C1-4 , alquilsulfonil C1-4 -alquilo C1-4 , arilsulfonilo, arilsulfoniloxi, arilsulfonil-alquilo C1-4 , alquil C1-4 -sulfonamido, alquil C1-4 -amido, alquil C1-4 -sulfonamido-alquilo C1-4 , alquil C1-4 - amido-alquilo C1-4 , arilsulfonamido, arilcarboxamido, arilsulfonamido-alquilo C1-4 , arilcarboxamido-alquilo C1-4 , aroílo, aroil-alquilo C1-4 , o aril-alcanoílo C1-4 ; un grupo R3 OCO(CH2 )p , R3 CON(R4 )(CH2 )p , R3 R4 NCO(CH2 )p o R3 R4 NSO2 (CH2 )p , donde cada uno de R3 y R4 representa independientemente un átomo de hidrógeno o un grupo alquilo C1-4 , o R3 R4 forma parte de un anillo azacicloalcano C3-6 o (2-oxo)azacicloalcano C3-6 , y p representa cero o un número entero de 1 a 4; o un grupo Ar3 -Z, en el cual Ar3 representa un anillo de fenilo opcionalmente sustituido o un anillo aromático heterocíclico de 5 ó 6 miembros opcionalmente sustituido, y Z representa un enlace, O, S o CH2 ; R2 representa un atomo de hidrógeno o un grupo alquilo C1-4 ; q es 1 ó 2; A representa un grupo de la fórmula (a), (b) o (c): en las cuales Ar representa un anillo de fenilo opcionalmente sustituido o un anillo aromático heterocíclico de 5 ó 6 miembros opcionalmente sustituido, o un sistema de anillos bicíclico opcionalmente sustituido; ...A compound of formula (I): in which: R 1 represents a substituent selected from: a hydrogen or halogen atom; a hydroxy, cyano, nitro, trifluoromethyl, trifluoromethoxy, trifluoromethanesulfonyloxy, pertafluoroethyl, C1-4 alkyl, C1-4 alkoxy, aryl-C1-4 alkoxy, C1-4 alkylthio, C1-4 alkoxy-C1-4 alkyl, C3 cycloalkyl group -6 - C 1-4 alkoxy, C 1-4 alkanoyl, C 1-4 alkoxy-carbonyl, C 1-4 alkylsulfonyl, C 1-4 alkylsulfonyloxy, C 1-4 alkylsulfonyl, C 1-4 alkyl, arylsulfonyl, arylsulfonyloxy, arylsulfonyl-C 1-4 alkyl , C1-4 alkyl sulfonamido, C1-4 alkyl amido, C1-4 alkyl sulfonamido C1-4 alkyl, C1-4 alkyl amido C1-4 alkyl, arylsulfonamido, arylcarboxamido, arylsulfonamido C1-4 alkyl, arylcarboxamido-C1-4 alkyl, aroyl, aroyl-C1-4 alkyl, or aryl-C1-4 alkanoyl; a group R3 OCO (CH2) p, R3 CON (R4) (CH2) p, R3 R4 NCO (CH2) or R3 R4 NSO2 (CH2) p, where each of R3 and R4 independently represents a hydrogen atom or a group C1-4 alkyl, or R3 R4 is part of a C3-6 azacycloalkane or C3-6 (2-oxo) azacycloalkane ring, and p represents zero or an integer from 1 to 4; or an Ar3 -Z group, in which Ar3 represents an optionally substituted phenyl ring or an optionally substituted 5 or 6 membered heterocyclic aromatic ring, and Z represents a bond, O, S or CH2; R2 represents a hydrogen atom or a C1-4 alkyl group; q is 1 or 2; A represents a group of the formula (a), (b) or (c): in which Ar represents an optionally substituted phenyl ring or an optionally substituted 5 or 6 membered heterocyclic aromatic ring, or an optionally bicyclic ring system replaced; ...

CO98023497A 1997-05-03 1998-04-29 NEW DERIVATIVES OF TETRAHYDROISOQUINOLEINE AND PROCEDURES FOR THEIR PREPARATION CO5050329A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9708976.7A GB9708976D0 (en) 1997-05-03 1997-05-03 Compounds

Publications (1)

Publication Number Publication Date
CO5050329A1 true CO5050329A1 (en) 2001-06-27

Family

ID=10811734

Family Applications (1)

Application Number Title Priority Date Filing Date
CO98023497A CO5050329A1 (en) 1997-05-03 1998-04-29 NEW DERIVATIVES OF TETRAHYDROISOQUINOLEINE AND PROCEDURES FOR THEIR PREPARATION

Country Status (4)

Country Link
KR (1) KR20010012205A (en)
CO (1) CO5050329A1 (en)
GB (1) GB9708976D0 (en)
ZA (1) ZA983659B (en)

Also Published As

Publication number Publication date
KR20010012205A (en) 2001-02-15
ZA983659B (en) 1999-11-01
GB9708976D0 (en) 1997-06-25

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