CO5040223A1 - METABOLIC EFFECTS OF CERTAIN GLUTATIONA ANALOGS - Google Patents

METABOLIC EFFECTS OF CERTAIN GLUTATIONA ANALOGS

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Publication number
CO5040223A1
CO5040223A1 CO96029266A CO96029266A CO5040223A1 CO 5040223 A1 CO5040223 A1 CO 5040223A1 CO 96029266 A CO96029266 A CO 96029266A CO 96029266 A CO96029266 A CO 96029266A CO 5040223 A1 CO5040223 A1 CO 5040223A1
Authority
CO
Colombia
Prior art keywords
amide
ester
bone marrow
glutationa
analogs
Prior art date
Application number
CO96029266A
Other languages
Spanish (es)
Inventor
Matthew H Lyttle
Amy S Morgan
Original Assignee
Terrapin Tech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/482,645 external-priority patent/US5767086A/en
Application filed by Terrapin Tech Inc filed Critical Terrapin Tech Inc
Publication of CO5040223A1 publication Critical patent/CO5040223A1/en

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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Los compuestos de fórmulao las formas de éster, amida, éster/amida o sal del mismo, en donde YCO es ?-glu o ßasp; G* es fenilglicina; Z es CH2 O ó S; y X es un radical hidrocaburo de 1-20C; son útiles a la hora de modular hematopoiesis en médula ósea, mitigar los efectos destructivos de un agente quimioterapéutico sobre la medula ósea y potenciar la toxicidad de agentes quimioterapéuticos.Un método para modular hematopoiesis, caracterizado porque comprende poner en contacto médula ósea o sangre periférica o fracciones de las mismas con un compuesto de fórmulao las formas de éster, amida, éster/amida o sal del mismo, en donde YCO es ?-glu o ß-asp; G* es fenilglicina o glicina; Z es CH2 , O ó S; y X es un radical hidrocarburo de 1-20C; en una cantidad y durante un tiempo eficaces para modular hematopoiesis en las referidas médula ósea, sangre periférica o fracciones de las mismas.Un método según la reivindicación 1, caracterizado porque Z es S.Un método según la reivindicación 1, caracterizado porque X es un hexilo, heptilo, octilo, bencilo o naftilo.Compounds of formula or ester, amide, ester / amide or salt forms thereof, wherein YCO is? -Glu or ßasp; G * is phenylglycine; Z is CH2 O or S; and X is a hydrocarbon radical of 1-20C; they are useful when modulating hematopoiesis in bone marrow, mitigating the destructive effects of a chemotherapeutic agent on the bone marrow and enhancing the toxicity of chemotherapeutic agents.A method to modulate hematopoiesis, characterized in that it comprises contacting bone marrow or peripheral blood or fractions thereof with a compound of formula or the forms of ester, amide, ester / amide or salt thereof, wherein YCO is? -glu or β-asp; G * is phenylglycine or glycine; Z is CH2, O or S; and X is a hydrocarbon radical of 1-20C; in an amount and for an effective time to modulate hematopoiesis in said bone marrow, peripheral blood or fractions thereof. A method according to claim 1, characterized in that Z is S. A method according to claim 1, characterized in that X is a hexyl, heptyl, octyl, benzyl or naphthyl.

CO96029266A 1995-06-07 1996-06-06 METABOLIC EFFECTS OF CERTAIN GLUTATIONA ANALOGS CO5040223A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/482,645 US5767086A (en) 1992-04-03 1995-06-07 Bone marrow stimulation by certain glutathione analogs
US63651696A 1996-04-19 1996-04-19

Publications (1)

Publication Number Publication Date
CO5040223A1 true CO5040223A1 (en) 2001-05-29

Family

ID=40943263

Family Applications (1)

Application Number Title Priority Date Filing Date
CO96029266A CO5040223A1 (en) 1995-06-07 1996-06-06 METABOLIC EFFECTS OF CERTAIN GLUTATIONA ANALOGS

Country Status (1)

Country Link
CO (1) CO5040223A1 (en)

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