CO5040060A1 - DERIVATIVES OF N-BENCILAZOLIO - Google Patents

DERIVATIVES OF N-BENCILAZOLIO

Info

Publication number
CO5040060A1
CO5040060A1 CO97051584A CO97051584A CO5040060A1 CO 5040060 A1 CO5040060 A1 CO 5040060A1 CO 97051584 A CO97051584 A CO 97051584A CO 97051584 A CO97051584 A CO 97051584A CO 5040060 A1 CO5040060 A1 CO 5040060A1
Authority
CO
Colombia
Prior art keywords
independently
derivatives
general formula
hydrogen
formula
Prior art date
Application number
CO97051584A
Other languages
Spanish (es)
Inventor
Ichihara Shigeyasu
Murasaki Chikako
Ohga Noriko
Ohwada Jun
Sawada Daisuke
Shimma Nobuo
Shirai Michio
Umeda Isao
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CO5040060A1 publication Critical patent/CO5040060A1/en

Links

Abstract

Los derivados de N-bencilazolio, de fórmula general(I)en donde Q es el resto de un compuesto de azol de fórmula II Que posee actividad antifúngica; Z es nitrógeno o metino; R1 y R2 son cada uno independientemente entre sí, un átomo de hidrógeno o un grupo -OY [en el cual y es un grupo fácilmente hidrolizable en condiciones fisiológicas]; R3 y R4 son cada uno independientemente entre sí, un átomo de hidrógeno o halógeno, alquilo inferior, alcoxilo inferior, alquiltio inferior, (alquilcarbonilo inferior) tiometilo, carboxilo o metoxicarbonilo; y X- es un anión farmacéuticamente aceptable, así como las sales, hidratos o solvatos de los compuestos de fórmula general (I).The N-benzylazolium derivatives, of general formula (I) wherein Q is the remainder of an azol compound of formula II which possesses antifungal activity; Z is nitrogen or methine; R1 and R2 are each independently of each other, a hydrogen atom or a group -OY [in which and is an easily hydrolyzable group under physiological conditions]; R3 and R4 are each independently from each other, a hydrogen or halogen atom, lower alkyl, lower alkoxy, lower alkylthio, (lower alkylcarbonyl) thiomethyl, carboxyl or methoxycarbonyl; and X- is a pharmaceutically acceptable anion, as well as the salts, hydrates or solvates of the compounds of general formula (I).

CO97051584A 1996-09-09 1997-09-05 DERIVATIVES OF N-BENCILAZOLIO CO5040060A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96114390 1996-09-09

Publications (1)

Publication Number Publication Date
CO5040060A1 true CO5040060A1 (en) 2001-05-29

Family

ID=8223168

Family Applications (1)

Application Number Title Priority Date Filing Date
CO97051584A CO5040060A1 (en) 1996-09-09 1997-09-05 DERIVATIVES OF N-BENCILAZOLIO

Country Status (11)

Country Link
AR (1) AR009555A1 (en)
BR (1) BR9704674A (en)
CO (1) CO5040060A1 (en)
HR (1) HRP970479A2 (en)
PE (1) PE108298A1 (en)
PL (1) PL322014A1 (en)
SG (1) SG67992A1 (en)
TR (1) TR199700927A2 (en)
TW (1) TW415947B (en)
UY (1) UY24699A1 (en)
ZA (1) ZA977881B (en)

Also Published As

Publication number Publication date
PL322014A1 (en) 1998-03-16
BR9704674A (en) 1999-05-18
HRP970479A2 (en) 1998-08-31
PE108298A1 (en) 1999-01-29
ZA977881B (en) 1998-03-09
SG67992A1 (en) 1999-10-19
TR199700927A3 (en) 1999-03-22
TR199700927A2 (en) 1999-03-22
AR009555A1 (en) 2000-04-26
UY24699A1 (en) 2000-12-29
TW415947B (en) 2000-12-21

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