CO5011083A1 - A PROCESS TO PREPARE PROSTAGLANDINA F ANALOGS - Google Patents

A PROCESS TO PREPARE PROSTAGLANDINA F ANALOGS

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Publication number
CO5011083A1
CO5011083A1 CO98054668A CO98054668A CO5011083A1 CO 5011083 A1 CO5011083 A1 CO 5011083A1 CO 98054668 A CO98054668 A CO 98054668A CO 98054668 A CO98054668 A CO 98054668A CO 5011083 A1 CO5011083 A1 CO 5011083A1
Authority
CO
Colombia
Prior art keywords
ring
hydrogen
aliphatic
carbocyclic
lower alkyl
Prior art date
Application number
CO98054668A
Other languages
Spanish (es)
Inventor
Joh August Wos
Long Mitchell Anthony De
De Biswanath
George Dai Haiyan
Sopen David Lindsey
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Priority to CO98054668A priority Critical patent/CO5011083A1/en
Publication of CO5011083A1 publication Critical patent/CO5011083A1/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se relaciona con un procedimiento paraelaborar un análogo de prostaglandina f que tiene una extructura de acuerdo con la Fórmula donde: a) R1 es CO2 H, C(O)NHOH, CO2 R5 , CH2 OH, S(O)2 R5 , C(O)NHR5 , C(O)NHS(O)2 R5 o tetrazol; donde R5 es alquilo, heteroalquilo, anillo alifático carbocíclico, anillo alifático heterocíclico, anillo aromático o anillo heteroaromático; b) R2 es hidrógeno o alquilo inferior; c) Cada R3 es independientemente seleccionado del grupo consistente de hidrógeno, alquilo inferior, alcoxi, haloalquilo, anillo alifático carbocíclico, anillo alifático eterocíclico, anillo aromático y anillo heteroaromático; d) Y es NR4 , S, S(O), S(O)2 , O ó un enlace, dado que ningún carbono tenga más de un heteroaroátomo adherido a él, donde R4 es hidrógeno, alquilo inferior o acilo; e) p es desde 0 hasta 5, q es desde 0 hasta 5 y p+q es desde 0 hasta 5, dado que cuando Y es un enlace p es al menos 1; y f) Z es hidrógeno, metilo, un anillo alifático carbocíclico, anillo alifático heterocíclico, anillo aromático o anillo heteroaromático dado que cuando Y es S(O) ó S(O)2 Z no es hidrógeno; el procedimiento comprende los pasos de: I) preparar un intermedio que tiene una extructura de acuerdo con la Fórmula (A): donde en (A) R6 es un ácido carboxílico, un éster de ácido carboxílico que contiene un alquilo C1 -C8 saturado o no saturado lineal o ramificado, un anillo carbocíclico, un ácido hidroxámico, ...The present invention relates to a process for developing a prostaglandin f analog having an structure according to the Formula where: a) R1 is CO2 H, C (O) NHOH, CO2 R5, CH2 OH, S (O) 2 R5 , C (O) NHR5, C (O) NHS (O) 2 R5 or tetrazole; where R5 is alkyl, heteroalkyl, carbocyclic aliphatic ring, heterocyclic aliphatic ring, aromatic ring or heteroaromatic ring; b) R2 is hydrogen or lower alkyl; c) Each R3 is independently selected from the group consisting of hydrogen, lower alkyl, alkoxy, haloalkyl, aliphatic carbocyclic ring, aliphatic ether ring, aromatic ring and heteroaromatic ring; d) Y is NR4, S, S (O), S (O) 2, O or a bond, since no carbon has more than one heteroaroatom attached to it, where R4 is hydrogen, lower alkyl or acyl; e) p is from 0 to 5, q is from 0 to 5 and p + q is from 0 to 5, since when Y is a link p is at least 1; and f) Z is hydrogen, methyl, a carbocyclic aliphatic ring, heterocyclic aliphatic ring, aromatic ring or heteroaromatic ring since when Y is S (O) or S (O) 2 Z is not hydrogen; The process comprises the steps of: I) preparing an intermediate having an structure according to Formula (A): where in (A) R6 is a carboxylic acid, a carboxylic acid ester containing a saturated C1-C8 alkyl or unsaturated linear or branched, a carbocyclic ring, a hydroxamic acid, ...

CO98054668A 1998-09-22 1998-09-22 A PROCESS TO PREPARE PROSTAGLANDINA F ANALOGS CO5011083A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CO98054668A CO5011083A1 (en) 1998-09-22 1998-09-22 A PROCESS TO PREPARE PROSTAGLANDINA F ANALOGS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CO98054668A CO5011083A1 (en) 1998-09-22 1998-09-22 A PROCESS TO PREPARE PROSTAGLANDINA F ANALOGS

Publications (1)

Publication Number Publication Date
CO5011083A1 true CO5011083A1 (en) 2001-02-28

Family

ID=40935294

Family Applications (1)

Application Number Title Priority Date Filing Date
CO98054668A CO5011083A1 (en) 1998-09-22 1998-09-22 A PROCESS TO PREPARE PROSTAGLANDINA F ANALOGS

Country Status (1)

Country Link
CO (1) CO5011083A1 (en)

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