CO4940440A1 - NEW CHROMANES OF FORMULA I, ITS PREPARATION, ITS USE AS PHARMACEUTICAL PRODUCTS AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM - Google Patents

NEW CHROMANES OF FORMULA I, ITS PREPARATION, ITS USE AS PHARMACEUTICAL PRODUCTS AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM

Info

Publication number
CO4940440A1
CO4940440A1 CO98021898A CO98021898A CO4940440A1 CO 4940440 A1 CO4940440 A1 CO 4940440A1 CO 98021898 A CO98021898 A CO 98021898A CO 98021898 A CO98021898 A CO 98021898A CO 4940440 A1 CO4940440 A1 CO 4940440A1
Authority
CO
Colombia
Prior art keywords
carbon atoms
alkyl
formula
hydrogen
chromanes
Prior art date
Application number
CO98021898A
Other languages
Spanish (es)
Inventor
Robert Swoboda
Villar Esteban Pombo
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CO4940440A1 publication Critical patent/CO4940440A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se relaciona con un compuesto de laFórmula I:en donde:R1 , y R2 , independientemente, son hidrógeno, alquilo (de 1 a 4 átomos de carbono), alcoxi (de 1 a 4 átomos de carbono), tioalquilo (de 1 a 4 átomos de carbono), halógeno trifluorometilo, trifluorometoxi, ciano, alcanoilo de 2 a 5 átomos de carbono), alquilo (de 1 a 4 átomos de carbono)-sulfonilo, o sulfamoílo, siendo cuando menos uno de R1 y R2 diferente de hidrógeno. R3 es hidrógeno, hidroxi, alquilo (de 1 a 4 átomos de carbono), alcoxi (de 1 a 4 átomos de carbono) cicloalcoxi (de 3 a 6 átomos de carbono), halógeno, ciano, alcanoílo (de 2 a 5 átomos de carbono), carbamoílo, alquilo (de 1 a 4 átomos de carbono)-sulfoniloxi, o trifluorometilsulfoniloxi; y R4 y R5 , independientemente, son hidrógeno alquilo (de 1 a 4 átomos de carbono), hidroxialquilo (de 1 a 4 átomos de carbono), o fenilalquilo (de 1 a 4 átomos de carbono), o forman, junto con el átomo de nitrógeno con el que está unido, un grupo pirrolidinilo, piperidino, piperazinilo, o morfolino;en forma de base libre o de sal de adición de ácido.The present invention relates to a compound of Formula I: wherein: R1, and R2, independently, are hydrogen, alkyl (from 1 to 4 carbon atoms), alkoxy (from 1 to 4 carbon atoms), thioalkyl (from 1 to 4 carbon atoms), halogen trifluoromethyl, trifluoromethoxy, cyano, C 2 -C 5 alkanoyl), alkyl (C 1 to 4 carbon) -sulfonyl, or sulfamoyl, at least one of R1 and R2 being different hydrogen. R3 is hydrogen, hydroxy, alkyl (from 1 to 4 carbon atoms), alkoxy (from 1 to 4 carbon atoms) cycloalkoxy (from 3 to 6 carbon atoms), halogen, cyano, alkanoyl (from 2 to 5 carbon atoms) carbon), carbamoyl, alkyl (1 to 4 carbon atoms) -sulfonyloxy, or trifluoromethylsulfonyloxy; and R4 and R5, independently, are hydrogen alkyl (from 1 to 4 carbon atoms), hydroxyalkyl (from 1 to 4 carbon atoms), or phenylalkyl (from 1 to 4 carbon atoms), or form, together with the atom of nitrogen to which it is attached, a pyrrolidinyl, piperidino, piperazinyl, or morpholino group, in the form of a free base or an acid addition salt.

CO98021898A 1997-04-23 1998-04-21 NEW CHROMANES OF FORMULA I, ITS PREPARATION, ITS USE AS PHARMACEUTICAL PRODUCTS AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM CO4940440A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9708235.8A GB9708235D0 (en) 1997-04-23 1997-04-23 Organic compounds

Publications (1)

Publication Number Publication Date
CO4940440A1 true CO4940440A1 (en) 2000-07-24

Family

ID=10811237

Family Applications (1)

Application Number Title Priority Date Filing Date
CO98021898A CO4940440A1 (en) 1997-04-23 1998-04-21 NEW CHROMANES OF FORMULA I, ITS PREPARATION, ITS USE AS PHARMACEUTICAL PRODUCTS AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM

Country Status (7)

Country Link
AR (1) AR012487A1 (en)
AU (1) AU7527798A (en)
CO (1) CO4940440A1 (en)
GB (1) GB9708235D0 (en)
PE (1) PE69599A1 (en)
WO (1) WO1998047889A1 (en)
ZA (1) ZA983370B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2699568C (en) * 1999-12-24 2013-03-12 Aventis Pharma Limited Azaindoles

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2660657B1 (en) * 1990-04-09 1993-05-07 Adir NOVEL 3-AMINOCHROMANE DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.

Also Published As

Publication number Publication date
AR012487A1 (en) 2000-10-18
ZA983370B (en) 1998-10-23
PE69599A1 (en) 1999-08-23
AU7527798A (en) 1998-11-13
GB9708235D0 (en) 1997-06-11
WO1998047889A1 (en) 1998-10-29

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